Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056500846> ?p ?o ?g. }
- W2056500846 endingPage "e19419" @default.
- W2056500846 startingPage "e19419" @default.
- W2056500846 abstract "Radial Glia (RG) cells constitute the major population of neural progenitors of the mouse developing brain. These cells are located in the ventricular zone (VZ) of the cerebral cortex and during neurogenesis they support the generation of cortical neurons. Later on, during brain maturation, RG cells give raise to glial cells and supply the adult mouse brain of Neural Stem Cells (NSC). Here we used a novel transgenic mouse line expressing the CreERT2 under the control of AspM promoter to monitor the progeny of an early cohort of RG cells during neurogenesis and in the post natal brain. Long term fate mapping experiments demonstrated that AspM-expressing RG cells are multi-potent, as they can generate neurons, astrocytes and oligodendrocytes of the adult mouse brain. Furthermore, AspM descendants give also rise to proliferating progenitors in germinal niches of both developing and post natal brains. In the latter –i.e. the Sub Ventricular Zone- AspM descendants acquired several feature of neural stem cells, including the capability to generate neurospheres in vitro. We also performed the selective killing of these early progenitors by using a Nestin-GFPflox-TK allele. The forebrain specific loss of early AspM expressing cells caused the elimination of most of the proliferating cells of brain, a severe derangement of the ventricular zone architecture, and the impairment of the cortical lamination. We further demonstrated that AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons." @default.
- W2056500846 created "2016-06-24" @default.
- W2056500846 creator A5012398608 @default.
- W2056500846 creator A5018024307 @default.
- W2056500846 creator A5022588272 @default.
- W2056500846 creator A5055711554 @default.
- W2056500846 creator A5062817428 @default.
- W2056500846 creator A5066150403 @default.
- W2056500846 creator A5082239692 @default.
- W2056500846 creator A5090171277 @default.
- W2056500846 date "2011-04-29" @default.
- W2056500846 modified "2023-10-14" @default.
- W2056500846 title "In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Features of Embryonic AspM Expressing Cells" @default.
- W2056500846 cites W1503727145 @default.
- W2056500846 cites W1556520758 @default.
- W2056500846 cites W1566969252 @default.
- W2056500846 cites W1643680178 @default.
- W2056500846 cites W1768274470 @default.
- W2056500846 cites W1859089489 @default.
- W2056500846 cites W1859730138 @default.
- W2056500846 cites W1964692745 @default.
- W2056500846 cites W1972022525 @default.
- W2056500846 cites W1975087758 @default.
- W2056500846 cites W1979690213 @default.
- W2056500846 cites W1980940171 @default.
- W2056500846 cites W1983955843 @default.
- W2056500846 cites W1984637659 @default.
- W2056500846 cites W1985678203 @default.
- W2056500846 cites W1988976106 @default.
- W2056500846 cites W1990906839 @default.
- W2056500846 cites W1990935914 @default.
- W2056500846 cites W1992620103 @default.
- W2056500846 cites W1993710236 @default.
- W2056500846 cites W1995933579 @default.
- W2056500846 cites W1998821964 @default.
- W2056500846 cites W2002514998 @default.
- W2056500846 cites W2003426511 @default.
- W2056500846 cites W2007242343 @default.
- W2056500846 cites W2015433283 @default.
- W2056500846 cites W2020539766 @default.
- W2056500846 cites W2021562536 @default.
- W2056500846 cites W2023105628 @default.
- W2056500846 cites W2026598324 @default.
- W2056500846 cites W2030508161 @default.
- W2056500846 cites W2035250926 @default.
- W2056500846 cites W2043772793 @default.
- W2056500846 cites W2048784291 @default.
- W2056500846 cites W2054226892 @default.
- W2056500846 cites W2055839901 @default.
- W2056500846 cites W2066153615 @default.
- W2056500846 cites W2066356973 @default.
- W2056500846 cites W2068229930 @default.
- W2056500846 cites W2068727148 @default.
- W2056500846 cites W2069259673 @default.
- W2056500846 cites W2079356804 @default.
- W2056500846 cites W2080931209 @default.
- W2056500846 cites W2082178034 @default.
- W2056500846 cites W2084652820 @default.
- W2056500846 cites W2084773215 @default.
- W2056500846 cites W2085274174 @default.
- W2056500846 cites W2088654564 @default.
- W2056500846 cites W2089135158 @default.
- W2056500846 cites W2089394861 @default.
- W2056500846 cites W2094980562 @default.
- W2056500846 cites W2096796354 @default.
- W2056500846 cites W2096960876 @default.
- W2056500846 cites W2099150119 @default.
- W2056500846 cites W2103035251 @default.
- W2056500846 cites W2108340830 @default.
- W2056500846 cites W2111145604 @default.
- W2056500846 cites W2112041130 @default.
- W2056500846 cites W2116521234 @default.
- W2056500846 cites W2125789834 @default.
- W2056500846 cites W2133810562 @default.
- W2056500846 cites W2136662452 @default.
- W2056500846 cites W2137801136 @default.
- W2056500846 cites W2146417573 @default.
- W2056500846 cites W2148212562 @default.
- W2056500846 cites W2153676981 @default.
- W2056500846 cites W2157794983 @default.
- W2056500846 cites W2158083261 @default.
- W2056500846 cites W2158496649 @default.
- W2056500846 cites W2161687882 @default.
- W2056500846 cites W2165654213 @default.
- W2056500846 cites W2165867905 @default.
- W2056500846 cites W2165918134 @default.
- W2056500846 cites W2168945089 @default.
- W2056500846 cites W2172266256 @default.
- W2056500846 doi "https://doi.org/10.1371/journal.pone.0019419" @default.
- W2056500846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3084851" @default.
- W2056500846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21559369" @default.
- W2056500846 hasPublicationYear "2011" @default.
- W2056500846 type Work @default.
- W2056500846 sameAs 2056500846 @default.
- W2056500846 citedByCount "12" @default.
- W2056500846 countsByYear W20565008462012 @default.
- W2056500846 countsByYear W20565008462015 @default.
- W2056500846 countsByYear W20565008462019 @default.