FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056501140> ?p ?o ?g. }

• W2056501140 endingPage "2106" @default.
• W2056501140 startingPage "2091" @default.
• W2056501140 abstract "The p27(Kip1) (p27) cyclin-dependent kinase inhibitor and c-Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of p27 (CDKN1B) gene transcription by Forkhead box O proteins such as FOXO3a leads to growth arrest and apoptosis. Previously, we observed that B cell receptor (surface IgM) engagement of WEHI 231 immature B lymphoma cells with an anti-IgM antibody results in activation of FOXO3a, growth arrest and apoptosis. As ectopic c-Myc expression in these cells prevented anti-IgM induction of p27 and cell death, we hypothesized that c-Myc represses FOXO3a-mediated transcription. Here we show that c-Myc inhibits FOXO3a-mediated activation of the p27 promoter in multiple cell lines. The mechanism of this repression was explored using a combination of co-immunoprecipitation, oligonucleotide precipitation, and chromatin immunoprecipitation experiments. The studies demonstrate a functional association of FOXO3a and c-Myc on a proximal Forkhead binding element in the p27 promoter. This association involves the Myc box II domain of c-Myc and the N-terminal DNA-binding portion of FOXO3a. Analysis of publicly available microarray datasets showed an inverse pattern of c-MYC and p27 RNA expression in primary acute myeloid leukemia, prostate cancer and tongue squamous cell carcinoma samples. The inhibition of FOXO3a-mediated activation of the p27 gene by the high aberrant expression of c-Myc in many tumor cells likely contributes to their uncontrolled proliferation and invasive phenotype." @default.
• W2056501140 created "2016-06-24" @default.
• W2056501140 creator A5006536921 @default.
• W2056501140 creator A5015735297 @default.
• W2056501140 creator A5048381149 @default.
• W2056501140 creator A5054248259 @default.
• W2056501140 creator A5067039077 @default.
• W2056501140 creator A5071828386 @default.
• W2056501140 creator A5076516081 @default.
• W2056501140 creator A5079640868 @default.
• W2056501140 creator A5091250034 @default.
• W2056501140 date "2008-04-07" @default.
• W2056501140 modified "2023-09-24" @default.
• W2056501140 title "c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27Kip1 cyclin dependent kinase inhibitor" @default.
• W2056501140 cites W137827881 @default.
• W2056501140 cites W1481295510 @default.
• W2056501140 cites W1515573227 @default.
• W2056501140 cites W1631908837 @default.
• W2056501140 cites W1663117206 @default.
• W2056501140 cites W1942778846 @default.
• W2056501140 cites W1966828006 @default.
• W2056501140 cites W1995425358 @default.
• W2056501140 cites W1996413533 @default.
• W2056501140 cites W1997345702 @default.
• W2056501140 cites W1997555839 @default.
• W2056501140 cites W2005144583 @default.
• W2056501140 cites W2011785467 @default.
• W2056501140 cites W2013832070 @default.
• W2056501140 cites W2014977509 @default.
• W2056501140 cites W2017761226 @default.
• W2056501140 cites W2021457628 @default.
• W2056501140 cites W2023973783 @default.
• W2056501140 cites W2032888521 @default.
• W2056501140 cites W2040239915 @default.
• W2056501140 cites W2045907249 @default.
• W2056501140 cites W2046623154 @default.
• W2056501140 cites W2047816695 @default.
• W2056501140 cites W2049826056 @default.
• W2056501140 cites W2053855572 @default.
• W2056501140 cites W2054193017 @default.
• W2056501140 cites W2054891276 @default.
• W2056501140 cites W2060116181 @default.
• W2056501140 cites W2061617907 @default.
• W2056501140 cites W2062629127 @default.
• W2056501140 cites W2069414088 @default.
• W2056501140 cites W2074183372 @default.
• W2056501140 cites W2083189756 @default.
• W2056501140 cites W2083561654 @default.
• W2056501140 cites W2090759987 @default.
• W2056501140 cites W2091851050 @default.
• W2056501140 cites W2094305535 @default.
• W2056501140 cites W2095571907 @default.
• W2056501140 cites W2099364141 @default.
• W2056501140 cites W2113962581 @default.
• W2056501140 cites W2122686086 @default.
• W2056501140 cites W2123697148 @default.
• W2056501140 cites W2124261225 @default.
• W2056501140 cites W2126909895 @default.
• W2056501140 cites W2134199670 @default.
• W2056501140 cites W2137035181 @default.
• W2056501140 cites W2146052193 @default.
• W2056501140 cites W2155953052 @default.
• W2056501140 cites W2166525118 @default.
• W2056501140 cites W2171794420 @default.
• W2056501140 cites W2331185281 @default.
• W2056501140 cites W4245378753 @default.
• W2056501140 doi "https://doi.org/10.1002/jcb.21765" @default.
• W2056501140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18393360" @default.
• W2056501140 hasPublicationYear "2008" @default.
• W2056501140 type Work @default.
• W2056501140 sameAs 2056501140 @default.
• W2056501140 citedByCount "66" @default.
• W2056501140 countsByYear W20565011402012 @default.
• W2056501140 countsByYear W20565011402013 @default.
• W2056501140 countsByYear W20565011402014 @default.
• W2056501140 countsByYear W20565011402015 @default.
• W2056501140 countsByYear W20565011402016 @default.
• W2056501140 countsByYear W20565011402017 @default.
• W2056501140 countsByYear W20565011402018 @default.
• W2056501140 countsByYear W20565011402019 @default.
• W2056501140 countsByYear W20565011402020 @default.
• W2056501140 countsByYear W20565011402021 @default.
• W2056501140 countsByYear W20565011402022 @default.
• W2056501140 countsByYear W20565011402023 @default.
• W2056501140 crossrefType "journal-article" @default.
• W2056501140 hasAuthorship W2056501140A5006536921 @default.
• W2056501140 hasAuthorship W2056501140A5015735297 @default.
• W2056501140 hasAuthorship W2056501140A5048381149 @default.
• W2056501140 hasAuthorship W2056501140A5054248259 @default.
• W2056501140 hasAuthorship W2056501140A5067039077 @default.
• W2056501140 hasAuthorship W2056501140A5071828386 @default.
• W2056501140 hasAuthorship W2056501140A5076516081 @default.
• W2056501140 hasAuthorship W2056501140A5079640868 @default.
• W2056501140 hasAuthorship W2056501140A5091250034 @default.
• W2056501140 hasConcept C101762097 @default.
• W2056501140 hasConcept C104317684 @default.
• W2056501140 hasConcept C134320426 @default.
• W2056501140 hasConcept C150194340 @default.

• next