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- W2056501354 abstract "Viral RNA replication provides a useful system to study the structure and function of RNAs and the mechanism of RNA synthesis from RNA templates. Previously we demonstrated that a 27 nt RNA from brome mosaic virus (BMV) can direct correct initiation of genomic plus-strand RNA synthesis by the BMV replicase. In this study, using biochemical, nuclear magnetic resonance, and thermodynamic analyses, we determined that the secondary structure of this 27 nt RNA can be significantly altered and retain the ability to direct RNA synthesis. In contrast, we find that position-specific changes in the RNA sequence will affect replicase recognition, modulate the polymerization process, and contribute to the differential accumulation of viral RNAs. These functional results are in agreement with the phylogenetic analysis of BMV and related viral sequences and suggest that a similar mechanism of RNA synthesis takes place for members of the alphavirus superfamily." @default.
- W2056501354 created "2016-06-24" @default.
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- W2056501354 creator A5022426502 @default.
- W2056501354 creator A5044758772 @default.
- W2056501354 creator A5085012888 @default.
- W2056501354 date "1999-12-01" @default.
- W2056501354 modified "2023-10-14" @default.
- W2056501354 title "RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis 1 1Edited by D. E. Draper" @default.
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- W2056501354 doi "https://doi.org/10.1006/jmbi.1999.3297" @default.
- W2056501354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7172556" @default.
- W2056501354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10610788" @default.
- W2056501354 hasPublicationYear "1999" @default.
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