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- W2056501647 abstract "N-acylation of chitosan with various fatty acid (C6–C16) chlorides increased its hydrophobic character and made important changes in its structural features. Unmodified chitosan exhibited a low degree of order (DO) and a weak tablet crushing strength. Chitosan acylated with a short chain length (C6) possessed similar properties, but exhibited significant swelling. Acylation with longer side chains (C8–C16) resulted in a higher DO and crushing strength but lower swelling. The best mechanical characteristics and drug release properties were found for palmitoyl chitosan (substitution degree 40–50%) tablets with 20% acetaminophen as a tracer. The high stability of these monolithic tablets appears to be due to hydrophobic interactions between side chains, as shown by a more organized structure. Infrared spectroscopy, X-ray diffractometry and proton nuclear magnetic resonance analyses of palmitoyl chitosan were consistent with a hydrophobic self-assembling model. Drug dissolution kinetics showed longer release times for higher degrees of functionalization, i.e. 30 h (for 47% substitution) and 90 h (for 69% substitution), suggesting palmitoyl chitosan excipients as interesting candidates for oral and subdermal pharmaceutical applications." @default.
- W2056501647 created "2016-06-24" @default.
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- W2056501647 date "2003-11-01" @default.
- W2056501647 modified "2023-10-17" @default.
- W2056501647 title "N-acylated chitosan: hydrophobic matrices for controlled drug release" @default.
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- W2056501647 doi "https://doi.org/10.1016/s0168-3659(03)00327-4" @default.
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