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- W2056506502 abstract "In order to determine possible electrophysiologic correlates of negative feedback influences of glucocorticoids upon neuroendocrine secretory activity, the effects of various doses of corticosterone on paraventricular nucleus multiple-unit activity responses to neural stimuli were examined in conscious, freely moving male rats. In control animals, photic and acoustic stimulation significantly increased multiple-unit activity of the paraventricular nucleus by increments of 75% and 117% (P < 0.005), respectively. Doses between 0.1 and 5.0 mg of corticosterone produced a dose-dependent inhibition of responses to photic stimulation with a high correlation coefficient (r = −0.990). Corticosterone also caused an inhibition of paraventricular multiple-unit activity in response to acoustic stimulation, which was more effective than for photic stimulation, with complete blockade of response occurring with a dose of 1 mg corticosterone. These electrophysiologic findings, within a region of the hypothalamus known to contain corticotrophin-releasing factor cell bodies, may be related to reduced secretion of the hormone in response to the neurogenic stimuli employed, following glucocorticoid administration." @default.
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- W2056506502 title "Inhibition by corticosterone of paraventricular nucleus multiple-unit activity responses to sensory stimuli in freely moving rats" @default.
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- W2056506502 doi "https://doi.org/10.1016/0014-4886(86)90112-3" @default.
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