Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056510050> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2056510050 endingPage "294" @default.
- W2056510050 startingPage "289" @default.
- W2056510050 abstract "TRP channels are well recognized for their contributions to sensory transduction, responding to a wide variety of stimuli including temperature, nociceptive stimuli, touch, osmolarity and pheromones. In particular, the involvement of TRP channels in nociception has been extensively studied following the cloning of the capsaicin receptor, TRPV1. Painful diabetic peripheral neuropathy is described as a superficial burning pain, and it is one of the most commonly encountered neuropathic pain syndromes in clinical practice. We found that hypoxic and high glucose conditions commonly observed in diabetes potentiate TRPV1 activity without affecting TRPV1 expression both in native rat sensory neurons and HEK293 cells expressing rat TRPV1. The potentiation seems to be caused by phosphorylation of the serine residues of TRPV1 by PKC. These data indicate that PKC-dependent potentiation of TRPV1 activities under hypoxia and hyperglycemia might be involved in early diabetic neuropathy. Mechanisms for the detection of alkaline pH by sensory neurons are not well understood, although it is well accepted that acidic pH monitoring can be attributed to several ion channels, including TRPV1 and ASICs. We found that alkaline pH activates TRPA1 and that the TRPA1 activation is involved in nociception, using Ca2+-imaging and patch-clamp methods. In addition, intracellular alkalization activated TRPA1 at the whole-cell level, and single-channel openings were observed in the inside-out configuration. Furthermore, intraplantar injection of ammonium chloride into the mouse hind paw caused pain-related behaviors, which were not observed in TRPA1-deficient mice. These results suggest that alkaline pH causes pain sensation through activation of TRPA1." @default.
- W2056510050 created "2016-06-24" @default.
- W2056510050 creator A5074653699 @default.
- W2056510050 date "2010-03-01" @default.
- W2056510050 modified "2023-09-30" @default.
- W2056510050 title "Activation and Regulation of Nociceptive Transient Receptor Potential (TRP) Channels, TRPV1 and TRPA1" @default.
- W2056510050 cites W1511198581 @default.
- W2056510050 cites W2050781058 @default.
- W2056510050 cites W2051613742 @default.
- W2056510050 cites W2062480940 @default.
- W2056510050 cites W2070323381 @default.
- W2056510050 cites W2080252996 @default.
- W2056510050 cites W2106207830 @default.
- W2056510050 cites W2107705149 @default.
- W2056510050 cites W2109879418 @default.
- W2056510050 cites W2118612841 @default.
- W2056510050 cites W2120229762 @default.
- W2056510050 cites W2154843401 @default.
- W2056510050 cites W2156733405 @default.
- W2056510050 cites W4233595534 @default.
- W2056510050 doi "https://doi.org/10.1248/yakushi.130.289" @default.
- W2056510050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20190512" @default.
- W2056510050 hasPublicationYear "2010" @default.
- W2056510050 type Work @default.
- W2056510050 sameAs 2056510050 @default.
- W2056510050 citedByCount "15" @default.
- W2056510050 countsByYear W20565100502012 @default.
- W2056510050 countsByYear W20565100502014 @default.
- W2056510050 countsByYear W20565100502015 @default.
- W2056510050 countsByYear W20565100502018 @default.
- W2056510050 countsByYear W20565100502019 @default.
- W2056510050 countsByYear W20565100502020 @default.
- W2056510050 countsByYear W20565100502021 @default.
- W2056510050 countsByYear W20565100502023 @default.
- W2056510050 crossrefType "journal-article" @default.
- W2056510050 hasAuthorship W2056510050A5074653699 @default.
- W2056510050 hasBestOaLocation W20565100501 @default.
- W2056510050 hasConcept C126322002 @default.
- W2056510050 hasConcept C15490471 @default.
- W2056510050 hasConcept C155164980 @default.
- W2056510050 hasConcept C160145004 @default.
- W2056510050 hasConcept C163146387 @default.
- W2056510050 hasConcept C169760540 @default.
- W2056510050 hasConcept C170493617 @default.
- W2056510050 hasConcept C172659308 @default.
- W2056510050 hasConcept C185592680 @default.
- W2056510050 hasConcept C25274449 @default.
- W2056510050 hasConcept C2776354303 @default.
- W2056510050 hasConcept C2779245659 @default.
- W2056510050 hasConcept C2780051329 @default.
- W2056510050 hasConcept C55493867 @default.
- W2056510050 hasConcept C71924100 @default.
- W2056510050 hasConcept C86803240 @default.
- W2056510050 hasConcept C98274493 @default.
- W2056510050 hasConceptScore W2056510050C126322002 @default.
- W2056510050 hasConceptScore W2056510050C15490471 @default.
- W2056510050 hasConceptScore W2056510050C155164980 @default.
- W2056510050 hasConceptScore W2056510050C160145004 @default.
- W2056510050 hasConceptScore W2056510050C163146387 @default.
- W2056510050 hasConceptScore W2056510050C169760540 @default.
- W2056510050 hasConceptScore W2056510050C170493617 @default.
- W2056510050 hasConceptScore W2056510050C172659308 @default.
- W2056510050 hasConceptScore W2056510050C185592680 @default.
- W2056510050 hasConceptScore W2056510050C25274449 @default.
- W2056510050 hasConceptScore W2056510050C2776354303 @default.
- W2056510050 hasConceptScore W2056510050C2779245659 @default.
- W2056510050 hasConceptScore W2056510050C2780051329 @default.
- W2056510050 hasConceptScore W2056510050C55493867 @default.
- W2056510050 hasConceptScore W2056510050C71924100 @default.
- W2056510050 hasConceptScore W2056510050C86803240 @default.
- W2056510050 hasConceptScore W2056510050C98274493 @default.
- W2056510050 hasIssue "3" @default.
- W2056510050 hasLocation W20565100501 @default.
- W2056510050 hasLocation W20565100502 @default.
- W2056510050 hasOpenAccess W2056510050 @default.
- W2056510050 hasPrimaryLocation W20565100501 @default.
- W2056510050 hasRelatedWork W1995971403 @default.
- W2056510050 hasRelatedWork W1996303646 @default.
- W2056510050 hasRelatedWork W2008406257 @default.
- W2056510050 hasRelatedWork W2031264907 @default.
- W2056510050 hasRelatedWork W2038626393 @default.
- W2056510050 hasRelatedWork W2042364243 @default.
- W2056510050 hasRelatedWork W2056510050 @default.
- W2056510050 hasRelatedWork W2126148803 @default.
- W2056510050 hasRelatedWork W2166554306 @default.
- W2056510050 hasRelatedWork W2767735742 @default.
- W2056510050 hasVolume "130" @default.
- W2056510050 isParatext "false" @default.
- W2056510050 isRetracted "false" @default.
- W2056510050 magId "2056510050" @default.
- W2056510050 workType "article" @default.