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• W2056510623 abstract "La désescalade antibiotique en réanimation est une stratégie ayant un double but : assurer l'adéquation de l'antibiothérapie initiale probabiliste et diminuer l'émergence des germes multirésistants. Stricto sensu, la désescalade ne peut s'appliquer que chez les patients présentant, après 48 à 72 heures d'évolution, à la fois une amélioration de leur état clinique et des prélèvements bactériologiques positifs. La désescalade consiste à adapter étroitement le spectre de l'antibiothérapie curative aux données de l'antibiogramme. Cette stratégie est clairement proposée comme approche idéale du traitement des pneumonies nosocomiales. Elle peut également s'appliquer à l'ensemble des pathologies infectieuses de réanimation sous réserve de connaître la fiabilité des explorations microbiologiques et de savoir évaluer l'évolution clinique. De-escalation of antibiotic therapy is a strategy aiming both to provide adequate initial antimicrobial therapy and to minimize the risk of emerging resistance. Theoretically, de-escalation was only possible in patients exhibiting, 48–72 hours after the beginning of antimicrobial treatment, positive bacteriological cultures and clinical improvement. De-escalation is a switch from an initial broad-spectrum antibiotic therapy to a specific antibiotic therapy based on microbiological data. This management strategy is now considered as the best therapeutic approach in hospital-acquired pneumonia. It could be proposed for most infectious diseases encountered in ICU, subject to know the value of microbiological testing and to be able to evaluate the clinical outcome." @default.
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• W2056510623 date "2006-06-01" @default.
• W2056510623 modified "2023-09-25" @default.
• W2056510623 title "Indication, intérêts et limites de la désescalade antibiotique en réanimation" @default.
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• W2056510623 doi "https://doi.org/10.1016/j.reaurg.2006.02.001" @default.
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