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- W2056510722 abstract "Eight new 1-(3-methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanone and 1-(methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanol derivatives were synthesized and their chemical structures elucidated by UV, IR, 1H-NMR and elemental analysis. The analgesic activity of these compounds was investigated by a modified Koster test and constant temperature hot-plate test. Antiinflammatory activity of the compounds was screened by using the carrageenan hind-paw edema test. All the compounds showed higher analgesic activity than aspirin. Carrageenan edema inhibition of the compounds was higher than indomethacin. None of the compounds induced gastric ulceration." @default.
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- W2056510722 date "1993-01-01" @default.
- W2056510722 modified "2023-10-16" @default.
- W2056510722 title "1-(3-Methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanones and ethanols: analgesic and antiinflammatory activities" @default.
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- W2056510722 doi "https://doi.org/10.1016/0223-5234(93)90052-g" @default.
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