Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056511969> ?p ?o ?g. }
- W2056511969 abstract "Abstract Objectives Oxidative stress is emerging as an important issue in the pathogenesis of dementia. This study was conducted to investigate the possible neuroprotective effects of carvedilol against streptozotocin induced behavioural alterations and oxidative damage in rats. Methods An intracerbroventricular cannula was implanted in the lateral ventricles of male Wistar rats. Various behavioural (locomotor activity, Morris water maze task) and biochemical parameters (lipid peroxidation, nitrate concentration, catalase, acetylcholinesterase, reduced glutathione and protein) were assessed. Key findings Intracerebroventricular administration of streptozotocin caused a significant memory deficit as evaluated in the Morris water maze task paradigms, and caused marked oxidative damage as indicated by significant increases in malondialdehyde and nitrite levels, and depletion of superoxide dismutase, catalase and reduced glutathione levels. It also caused a significant increase in acetylcholinesterase activity. Chronic administration of carvedilol (1 and 2 mg/kg, i.p.) for a period of 25 days starting 4 days before streptozotocin administration resulted in an improvement in memory retention, and attenuation of oxidative damage and acetylcholinesterase activity. Conclusions This study demonstrates the effectiveness of carvedilol in preventing cognitive deficits as well as the oxidative stress caused by intracerbroventicular administration of streptozotocin in rats. Carvedilol may have potential in the treatment of neurodegenerative diseases." @default.
- W2056511969 created "2016-06-24" @default.
- W2056511969 creator A5031149703 @default.
- W2056511969 creator A5047004036 @default.
- W2056511969 date "2009-12-01" @default.
- W2056511969 modified "2023-09-25" @default.
- W2056511969 title "Effect of chronic treatment of carvedilol on oxidative stress in an intracerebroventricular streptozotocin induced model of dementia in rats" @default.
- W2056511969 cites W1506043065 @default.
- W2056511969 cites W1825808183 @default.
- W2056511969 cites W1968134494 @default.
- W2056511969 cites W1969043927 @default.
- W2056511969 cites W1969335469 @default.
- W2056511969 cites W1971048984 @default.
- W2056511969 cites W1972597180 @default.
- W2056511969 cites W1973210168 @default.
- W2056511969 cites W1974305753 @default.
- W2056511969 cites W1991707996 @default.
- W2056511969 cites W1999633791 @default.
- W2056511969 cites W2006370393 @default.
- W2056511969 cites W2008772195 @default.
- W2056511969 cites W2011538938 @default.
- W2056511969 cites W2025265744 @default.
- W2056511969 cites W2026547060 @default.
- W2056511969 cites W2027483621 @default.
- W2056511969 cites W2036057499 @default.
- W2056511969 cites W2036499934 @default.
- W2056511969 cites W2039059620 @default.
- W2056511969 cites W2040536037 @default.
- W2056511969 cites W2052915752 @default.
- W2056511969 cites W2062989356 @default.
- W2056511969 cites W2068210940 @default.
- W2056511969 cites W2076279968 @default.
- W2056511969 cites W2082904440 @default.
- W2056511969 cites W2084626714 @default.
- W2056511969 cites W2087105950 @default.
- W2056511969 cites W2090070919 @default.
- W2056511969 cites W2092742533 @default.
- W2056511969 cites W2111040212 @default.
- W2056511969 cites W2120527123 @default.
- W2056511969 cites W2129902275 @default.
- W2056511969 cites W2132710428 @default.
- W2056511969 cites W2140075873 @default.
- W2056511969 cites W2146729934 @default.
- W2056511969 cites W2146911942 @default.
- W2056511969 cites W2169441795 @default.
- W2056511969 cites W2317218026 @default.
- W2056511969 cites W2320157721 @default.
- W2056511969 doi "https://doi.org/10.1211/jpp.61.12.0012" @default.
- W2056511969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19958590" @default.
- W2056511969 hasPublicationYear "2009" @default.
- W2056511969 type Work @default.
- W2056511969 sameAs 2056511969 @default.
- W2056511969 citedByCount "12" @default.
- W2056511969 countsByYear W20565119692012 @default.
- W2056511969 countsByYear W20565119692013 @default.
- W2056511969 countsByYear W20565119692015 @default.
- W2056511969 countsByYear W20565119692016 @default.
- W2056511969 countsByYear W20565119692018 @default.
- W2056511969 countsByYear W20565119692021 @default.
- W2056511969 countsByYear W20565119692022 @default.
- W2056511969 countsByYear W20565119692023 @default.
- W2056511969 crossrefType "journal-article" @default.
- W2056511969 hasAuthorship W2056511969A5031149703 @default.
- W2056511969 hasAuthorship W2056511969A5047004036 @default.
- W2056511969 hasConcept C126322002 @default.
- W2056511969 hasConcept C134018914 @default.
- W2056511969 hasConcept C25498285 @default.
- W2056511969 hasConcept C2775838275 @default.
- W2056511969 hasConcept C2776151105 @default.
- W2056511969 hasConcept C2778198053 @default.
- W2056511969 hasConcept C2778401633 @default.
- W2056511969 hasConcept C2779280383 @default.
- W2056511969 hasConcept C2780591200 @default.
- W2056511969 hasConcept C2780829032 @default.
- W2056511969 hasConcept C2781161787 @default.
- W2056511969 hasConcept C44752575 @default.
- W2056511969 hasConcept C555293320 @default.
- W2056511969 hasConcept C71924100 @default.
- W2056511969 hasConcept C98274493 @default.
- W2056511969 hasConceptScore W2056511969C126322002 @default.
- W2056511969 hasConceptScore W2056511969C134018914 @default.
- W2056511969 hasConceptScore W2056511969C25498285 @default.
- W2056511969 hasConceptScore W2056511969C2775838275 @default.
- W2056511969 hasConceptScore W2056511969C2776151105 @default.
- W2056511969 hasConceptScore W2056511969C2778198053 @default.
- W2056511969 hasConceptScore W2056511969C2778401633 @default.
- W2056511969 hasConceptScore W2056511969C2779280383 @default.
- W2056511969 hasConceptScore W2056511969C2780591200 @default.
- W2056511969 hasConceptScore W2056511969C2780829032 @default.
- W2056511969 hasConceptScore W2056511969C2781161787 @default.
- W2056511969 hasConceptScore W2056511969C44752575 @default.
- W2056511969 hasConceptScore W2056511969C555293320 @default.
- W2056511969 hasConceptScore W2056511969C71924100 @default.
- W2056511969 hasConceptScore W2056511969C98274493 @default.
- W2056511969 hasLocation W20565119691 @default.
- W2056511969 hasLocation W20565119692 @default.
- W2056511969 hasOpenAccess W2056511969 @default.
- W2056511969 hasPrimaryLocation W20565119691 @default.
- W2056511969 hasRelatedWork W1500350553 @default.
- W2056511969 hasRelatedWork W1546369396 @default.