Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056511989> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2056511989 endingPage "751" @default.
- W2056511989 startingPage "740" @default.
- W2056511989 abstract "Background: Macrophages undergo maladaptive alterations after trauma. In this study, we assessed the role of Kupffer cells in hepatic microcirculatory response to endothelin-1 (ET-1) after femur fracture (FFx) and cecal ligation and puncture (CLP). Methods: Sprague-Dawley rats (200–300 g) underwent sham, FFx, CLP, or FFx + CLP. To ablate Kupffer cells, group 1 animals were treated with gadolinium chloride, and group 2 animals received saline. Hepatic microcirculation was assessed by intravital microscopy. Liver mitochondrial redox state and tissue oxygen (tPo2) were determined by NADH and ruthenium fluorescence, respectively. Liver damage was estimated by alanine aminotransferase levels. Differences were assessed using analysis of variance followed by Student-Newman-Keuls post hoc test. Results: After 10 minutes of ET-1, CLP and FFx + CLP caused significant reduction in hepatic perfusion index (2.5-fold and 5-fold vs. sham, p < 0.05, respectively), redox state (36% and 45% vs. sham, p < 0.01, respectively), tPo2 (10% and 12% vs. sham, p < 0.05, respectively), and more liver damage compared with sham and FFx-treated animals. Kupffer cell depletion restored microcirculation, redox state, and tPo2 and abrogated hepatocellular damage. Conclusion: Kupffer cells contribute directly to hepatic microcirculatory dysfunction and liver injury after inflammatory stress. Furthermore, Kupffer cell depletion ameliorates the microcirculatory perturbations of trauma and sepsis. Thus, modulation of Kupffer cell response may prove beneficial." @default.
- W2056511989 created "2016-06-24" @default.
- W2056511989 creator A5006751862 @default.
- W2056511989 creator A5011044871 @default.
- W2056511989 creator A5039019365 @default.
- W2056511989 creator A5044734485 @default.
- W2056511989 creator A5084298407 @default.
- W2056511989 date "2005-04-01" @default.
- W2056511989 modified "2023-10-17" @default.
- W2056511989 title "Kupffer Cell Ablation Improves Hepatic Microcirculation after Trauma and Sepsis" @default.
- W2056511989 cites W1978152500 @default.
- W2056511989 cites W1983846118 @default.
- W2056511989 cites W1989170366 @default.
- W2056511989 cites W1991261786 @default.
- W2056511989 cites W1995895016 @default.
- W2056511989 cites W2014806005 @default.
- W2056511989 cites W2023261735 @default.
- W2056511989 cites W2025128956 @default.
- W2056511989 cites W2027340801 @default.
- W2056511989 cites W2031292559 @default.
- W2056511989 cites W2034965411 @default.
- W2056511989 cites W2038240266 @default.
- W2056511989 cites W2052607851 @default.
- W2056511989 cites W2056059796 @default.
- W2056511989 cites W2059327396 @default.
- W2056511989 cites W2061651706 @default.
- W2056511989 cites W2067448001 @default.
- W2056511989 cites W2091884388 @default.
- W2056511989 cites W2111726911 @default.
- W2056511989 cites W2128723147 @default.
- W2056511989 cites W2138694854 @default.
- W2056511989 cites W2414350339 @default.
- W2056511989 doi "https://doi.org/10.1097/01.ta.0000158246.74816.18" @default.
- W2056511989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15824650" @default.
- W2056511989 hasPublicationYear "2005" @default.
- W2056511989 type Work @default.
- W2056511989 sameAs 2056511989 @default.
- W2056511989 citedByCount "33" @default.
- W2056511989 countsByYear W20565119892012 @default.
- W2056511989 countsByYear W20565119892013 @default.
- W2056511989 countsByYear W20565119892014 @default.
- W2056511989 countsByYear W20565119892015 @default.
- W2056511989 countsByYear W20565119892017 @default.
- W2056511989 crossrefType "journal-article" @default.
- W2056511989 hasAuthorship W2056511989A5006751862 @default.
- W2056511989 hasAuthorship W2056511989A5011044871 @default.
- W2056511989 hasAuthorship W2056511989A5039019365 @default.
- W2056511989 hasAuthorship W2056511989A5044734485 @default.
- W2056511989 hasAuthorship W2056511989A5084298407 @default.
- W2056511989 hasConcept C126322002 @default.
- W2056511989 hasConcept C12722491 @default.
- W2056511989 hasConcept C134018914 @default.
- W2056511989 hasConcept C142724271 @default.
- W2056511989 hasConcept C146957229 @default.
- W2056511989 hasConcept C2776151105 @default.
- W2056511989 hasConcept C2778384902 @default.
- W2056511989 hasConcept C2778904781 @default.
- W2056511989 hasConcept C2859252 @default.
- W2056511989 hasConcept C71924100 @default.
- W2056511989 hasConceptScore W2056511989C126322002 @default.
- W2056511989 hasConceptScore W2056511989C12722491 @default.
- W2056511989 hasConceptScore W2056511989C134018914 @default.
- W2056511989 hasConceptScore W2056511989C142724271 @default.
- W2056511989 hasConceptScore W2056511989C146957229 @default.
- W2056511989 hasConceptScore W2056511989C2776151105 @default.
- W2056511989 hasConceptScore W2056511989C2778384902 @default.
- W2056511989 hasConceptScore W2056511989C2778904781 @default.
- W2056511989 hasConceptScore W2056511989C2859252 @default.
- W2056511989 hasConceptScore W2056511989C71924100 @default.
- W2056511989 hasIssue "4" @default.
- W2056511989 hasLocation W20565119891 @default.
- W2056511989 hasLocation W20565119892 @default.
- W2056511989 hasOpenAccess W2056511989 @default.
- W2056511989 hasPrimaryLocation W20565119891 @default.
- W2056511989 hasRelatedWork W1972729343 @default.
- W2056511989 hasRelatedWork W1975227126 @default.
- W2056511989 hasRelatedWork W2007723183 @default.
- W2056511989 hasRelatedWork W2021675383 @default.
- W2056511989 hasRelatedWork W2052123576 @default.
- W2056511989 hasRelatedWork W2076615410 @default.
- W2056511989 hasRelatedWork W2401010498 @default.
- W2056511989 hasRelatedWork W2415863142 @default.
- W2056511989 hasRelatedWork W4246457101 @default.
- W2056511989 hasRelatedWork W4286855522 @default.
- W2056511989 hasVolume "58" @default.
- W2056511989 isParatext "false" @default.
- W2056511989 isRetracted "false" @default.
- W2056511989 magId "2056511989" @default.
- W2056511989 workType "article" @default.