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• W2056512397 abstract "Abstract A new PHEA‐IB‐PMANa + copolymer has been synthesized and its pH‐induced self‐assembly has been investigated in an aqueous medium. PHEA‐IB‐PMANa + formed nanoparticles with diameters from 25 to 50 nm upon protonation of the carboxylic acid moieties dislocated along the grafted polymethacrylate sodium salt side chains. The physico‐chemical characterization of the nanoparticles was performed using light scattering, zeta‐potential measurements, SEM, and AFM. Doxorubicin‐loaded nanoparticles were prepared and drug release profiles were evaluated under conditions mimicking physiological media. A biological characterization was carried out by testing the cytotoxicity on Caco‐2 cells, and cellular uptake on mouse monocyte macrophage (J774 A.1) and Caco‐2 cells. magnified image" @default.
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• W2056512397 date "2011-01-21" @default.
• W2056512397 modified "2023-10-12" @default.
• W2056512397 title "Polyaspartamide<i>-graft-</i> Polymethacrylate Nanoparticles for Doxorubicin Delivery" @default.
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• W2056512397 doi "https://doi.org/10.1002/mabi.201000399" @default.
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