Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056513257> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2056513257 endingPage "571" @default.
- W2056513257 startingPage "568" @default.
- W2056513257 abstract "<h2>Abstract</h2> A major gene for Hirschsprung's disease (HD) recently has been mapped in chromosome 10q11.2 and identified to be the<i>RET</i> proto-oncogene. Mutations of the<i>RET</i> gene have occurred in HD patients, and abnormalities of expression and function of Ret protein (a receptor tyrosine kinase, which is the product of the<i>RET</i> gene) have been found in their intestines. In vitro studies of the biological effects of HD mutations suggest a loss of function effect, which may be negative-dominant. However, the developmental role of the Ret protein in the organogenesis of the enteric nervous system (ENS) and its role in the pathogenesis of HD remain unclear. The authors present a study of the expression of Ret protein in the human ENS during fetal development. Fresh rectal tissues were obtained from nine fetuses (gestational age range, 12 to 22 weeks). Ret protein expression was studied immunohistochemically, using antibodies against the car☐y-terminal 20 amino acids (anti-Ret C) and the extracellular domain (anti-Ret R5). The tyrosine kinase activity of the fetal ENS was investigated with antiphosphotyrosine mouse monoclonal antibody against the phosphorylated tyrosine residues. Anti-Ret C immunostaining was observed in ganglion cells at all ages, but intense activity was significantly higher among the cells of the younger fetuses. Intense anti-Ret R5 immunostaining was present in the enteric ganglion cells of the 12-week-old fetus. The tyrosine kinase activity of ganglion cells increases progressively with advancing gestational age. The results of this study support the hypothesis that the Ret protein receptor might play a crucial role in the cellular and molecular processes involved in the development and maturation of the ENS, abnormalities of which could result in HD. High Ret protein expression and low tyrosine kinase activity have been reported to occur in small ganglia of the HD hypoganglionic segment. In the present study, these markers were typical of the primitive and immature ENS during the early phase of hindgut development." @default.
- W2056513257 created "2016-06-24" @default.
- W2056513257 creator A5010004205 @default.
- W2056513257 creator A5042317051 @default.
- W2056513257 creator A5042584066 @default.
- W2056513257 creator A5048038268 @default.
- W2056513257 creator A5061043112 @default.
- W2056513257 creator A5072088705 @default.
- W2056513257 date "1996-04-01" @default.
- W2056513257 modified "2023-09-26" @default.
- W2056513257 title "Ret protein in the human fetal rectum" @default.
- W2056513257 cites W1259302142 @default.
- W2056513257 cites W1511353372 @default.
- W2056513257 cites W1989457545 @default.
- W2056513257 cites W1999693507 @default.
- W2056513257 cites W2004166021 @default.
- W2056513257 cites W2025149315 @default.
- W2056513257 cites W2027734298 @default.
- W2056513257 cites W2030996806 @default.
- W2056513257 cites W2032359283 @default.
- W2056513257 cites W2050963778 @default.
- W2056513257 cites W2089055576 @default.
- W2056513257 cites W2090159403 @default.
- W2056513257 cites W2092282719 @default.
- W2056513257 cites W2124314287 @default.
- W2056513257 cites W2128805986 @default.
- W2056513257 cites W2129783333 @default.
- W2056513257 cites W2133802016 @default.
- W2056513257 cites W2134894529 @default.
- W2056513257 doi "https://doi.org/10.1016/s0022-3468(96)90498-4" @default.
- W2056513257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8801315" @default.
- W2056513257 hasPublicationYear "1996" @default.
- W2056513257 type Work @default.
- W2056513257 sameAs 2056513257 @default.
- W2056513257 citedByCount "12" @default.
- W2056513257 countsByYear W20565132572012 @default.
- W2056513257 countsByYear W20565132572013 @default.
- W2056513257 crossrefType "journal-article" @default.
- W2056513257 hasAuthorship W2056513257A5010004205 @default.
- W2056513257 hasAuthorship W2056513257A5042317051 @default.
- W2056513257 hasAuthorship W2056513257A5042584066 @default.
- W2056513257 hasAuthorship W2056513257A5048038268 @default.
- W2056513257 hasAuthorship W2056513257A5061043112 @default.
- W2056513257 hasAuthorship W2056513257A5072088705 @default.
- W2056513257 hasConcept C101544691 @default.
- W2056513257 hasConcept C126322002 @default.
- W2056513257 hasConcept C134018914 @default.
- W2056513257 hasConcept C142724271 @default.
- W2056513257 hasConcept C170493617 @default.
- W2056513257 hasConcept C172680121 @default.
- W2056513257 hasConcept C204232928 @default.
- W2056513257 hasConcept C2777439022 @default.
- W2056513257 hasConcept C2779234561 @default.
- W2056513257 hasConcept C4224716 @default.
- W2056513257 hasConcept C42362537 @default.
- W2056513257 hasConcept C54355233 @default.
- W2056513257 hasConcept C71924100 @default.
- W2056513257 hasConcept C86803240 @default.
- W2056513257 hasConceptScore W2056513257C101544691 @default.
- W2056513257 hasConceptScore W2056513257C126322002 @default.
- W2056513257 hasConceptScore W2056513257C134018914 @default.
- W2056513257 hasConceptScore W2056513257C142724271 @default.
- W2056513257 hasConceptScore W2056513257C170493617 @default.
- W2056513257 hasConceptScore W2056513257C172680121 @default.
- W2056513257 hasConceptScore W2056513257C204232928 @default.
- W2056513257 hasConceptScore W2056513257C2777439022 @default.
- W2056513257 hasConceptScore W2056513257C2779234561 @default.
- W2056513257 hasConceptScore W2056513257C4224716 @default.
- W2056513257 hasConceptScore W2056513257C42362537 @default.
- W2056513257 hasConceptScore W2056513257C54355233 @default.
- W2056513257 hasConceptScore W2056513257C71924100 @default.
- W2056513257 hasConceptScore W2056513257C86803240 @default.
- W2056513257 hasIssue "4" @default.
- W2056513257 hasLocation W20565132571 @default.
- W2056513257 hasLocation W20565132572 @default.
- W2056513257 hasOpenAccess W2056513257 @default.
- W2056513257 hasPrimaryLocation W20565132571 @default.
- W2056513257 hasRelatedWork W1973833989 @default.
- W2056513257 hasRelatedWork W1993795923 @default.
- W2056513257 hasRelatedWork W2002562299 @default.
- W2056513257 hasRelatedWork W2045448786 @default.
- W2056513257 hasRelatedWork W2056513257 @default.
- W2056513257 hasRelatedWork W2095329316 @default.
- W2056513257 hasRelatedWork W2099734673 @default.
- W2056513257 hasRelatedWork W2141521254 @default.
- W2056513257 hasRelatedWork W2155599231 @default.
- W2056513257 hasRelatedWork W2156499933 @default.
- W2056513257 hasVolume "31" @default.
- W2056513257 isParatext "false" @default.
- W2056513257 isRetracted "false" @default.
- W2056513257 magId "2056513257" @default.
- W2056513257 workType "article" @default.