FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056513283> ?p ?o ?g. }

• W2056513283 endingPage "251" @default.
• W2056513283 startingPage "246" @default.
• W2056513283 abstract "To gain more insight in the physiological function of the fragile X gene (FMR1) and the mechanisms leading to fragile X syndrome, the Fmr1 gene has been inactivated in mice by gene targeting techniques. In the Morris water maze test, the Fmr1 knockout mice learn to find the hidden platform nearly as well as the control animals, but show impaired performance after the position of the platform has been modified. As malperformance in the Morris water maze test has been associated with impaired long-term potentiation (LTP), electrophysiological studies were performed in hippocampal slices of Fmr1 knockout mice to check for the presence of LTP. Judged by field extracellular excitatory postsynaptic potential recordings in the CA1 hippocampal area, Fmr1 knockout mice express LTP to a similar extent as their wild type littermates during the first 1-2 hr after high frequency stimulation. Also, short-term potentiation (STP) was similar in both types of mice. To investigate whether Fmr1 is involved in the latter stages of LTP as an immediate early gene, we compared Fmr1 mRNA quantities on northern blots after chemical induction of seizures. A transient increase in the transcription of immediate early genes is thought to be essential for the maintenance of LTP. As no increase in Fmr1 mRNA could be detected, neither in cortex nor in total brain, during the first 2 1/2 hr after pentylenetetrazol-induced seizures, it is unlikely that Fmr1 is an immediate early gene in mice. In conclusion, we found no evidence for a function of FMR1 in STP or LTP." @default.
• W2056513283 created "2016-06-24" @default.
• W2056513283 creator A5020555281 @default.
• W2056513283 creator A5027033208 @default.
• W2056513283 creator A5049931800 @default.
• W2056513283 creator A5052290354 @default.
• W2056513283 creator A5073347333 @default.
• W2056513283 creator A5073485583 @default.
• W2056513283 creator A5086624624 @default.
• W2056513283 creator A5087301723 @default.
• W2056513283 creator A5090062507 @default.
• W2056513283 date "1996-08-09" @default.
• W2056513283 modified "2023-09-26" @default.
• W2056513283 title "Long-term potentiation in the hippocampus of fragile X knockout mice" @default.
• W2056513283 cites W1564811764 @default.
• W2056513283 cites W1969827462 @default.
• W2056513283 cites W1978236923 @default.
• W2056513283 cites W1999730046 @default.
• W2056513283 cites W2002780348 @default.
• W2056513283 cites W2003102216 @default.
• W2056513283 cites W2012666208 @default.
• W2056513283 cites W2014102314 @default.
• W2056513283 cites W2017169966 @default.
• W2056513283 cites W2019650070 @default.
• W2056513283 cites W2022224180 @default.
• W2056513283 cites W2028728671 @default.
• W2056513283 cites W2029184215 @default.
• W2056513283 cites W2031180717 @default.
• W2056513283 cites W2031379218 @default.
• W2056513283 cites W2035880579 @default.
• W2056513283 cites W2036338927 @default.
• W2056513283 cites W2044818530 @default.
• W2056513283 cites W2049511526 @default.
• W2056513283 cites W2054975255 @default.
• W2056513283 cites W2060314683 @default.
• W2056513283 cites W2067429214 @default.
• W2056513283 cites W2075344525 @default.
• W2056513283 cites W2082078122 @default.
• W2056513283 cites W2090501101 @default.
• W2056513283 cites W2094168800 @default.
• W2056513283 cites W2111354983 @default.
• W2056513283 cites W2144995800 @default.
• W2056513283 cites W2145107163 @default.
• W2056513283 cites W2149919973 @default.
• W2056513283 cites W2161815236 @default.
• W2056513283 cites W2169473035 @default.
• W2056513283 cites W275670288 @default.
• W2056513283 doi "https://doi.org/10.1002/(sici)1096-8628(19960809)64:2<246::aid-ajmg2>3.0.co;2-s" @default.
• W2056513283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8844057" @default.
• W2056513283 hasPublicationYear "1996" @default.
• W2056513283 type Work @default.
• W2056513283 sameAs 2056513283 @default.
• W2056513283 citedByCount "155" @default.
• W2056513283 countsByYear W20565132832012 @default.
• W2056513283 countsByYear W20565132832013 @default.
• W2056513283 countsByYear W20565132832014 @default.
• W2056513283 countsByYear W20565132832015 @default.
• W2056513283 countsByYear W20565132832016 @default.
• W2056513283 countsByYear W20565132832017 @default.
• W2056513283 countsByYear W20565132832018 @default.
• W2056513283 countsByYear W20565132832019 @default.
• W2056513283 countsByYear W20565132832020 @default.
• W2056513283 countsByYear W20565132832021 @default.
• W2056513283 countsByYear W20565132832022 @default.
• W2056513283 countsByYear W20565132832023 @default.
• W2056513283 crossrefType "journal-article" @default.
• W2056513283 hasAuthorship W2056513283A5020555281 @default.
• W2056513283 hasAuthorship W2056513283A5027033208 @default.
• W2056513283 hasAuthorship W2056513283A5049931800 @default.
• W2056513283 hasAuthorship W2056513283A5052290354 @default.
• W2056513283 hasAuthorship W2056513283A5073347333 @default.
• W2056513283 hasAuthorship W2056513283A5073485583 @default.
• W2056513283 hasAuthorship W2056513283A5086624624 @default.
• W2056513283 hasAuthorship W2056513283A5087301723 @default.
• W2056513283 hasAuthorship W2056513283A5090062507 @default.
• W2056513283 hasConcept C104317684 @default.
• W2056513283 hasConcept C112592302 @default.
• W2056513283 hasConcept C126322002 @default.
• W2056513283 hasConcept C134018914 @default.
• W2056513283 hasConcept C148762608 @default.
• W2056513283 hasConcept C169760540 @default.
• W2056513283 hasConcept C170493617 @default.
• W2056513283 hasConcept C17077164 @default.
• W2056513283 hasConcept C182704531 @default.
• W2056513283 hasConcept C25274449 @default.
• W2056513283 hasConcept C2777630245 @default.
• W2056513283 hasConcept C2779063550 @default.
• W2056513283 hasConcept C2781161787 @default.
• W2056513283 hasConcept C3020422209 @default.
• W2056513283 hasConcept C44752575 @default.
• W2056513283 hasConcept C54355233 @default.
• W2056513283 hasConcept C71924100 @default.
• W2056513283 hasConcept C86803240 @default.
• W2056513283 hasConceptScore W2056513283C104317684 @default.
• W2056513283 hasConceptScore W2056513283C112592302 @default.
• W2056513283 hasConceptScore W2056513283C126322002 @default.
• W2056513283 hasConceptScore W2056513283C134018914 @default.
• W2056513283 hasConceptScore W2056513283C148762608 @default.

• next