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• W2056513494 abstract "To assess the role of interleukin-1 (IL-1) in cutaneous leishmaniasis, Leishmania major-infected mice were treated with an anti-IL-1 receptor monoclonal antibody, LA-15.6. MoAb LA-15.6 prevents binding of IL-1 to both the T cell and B cell/macrophage forms of the IL-1 receptor. We found that treating with LA 15.6 inhibited the development of cutaneous lesions of L. major in both genetically-susceptible and resistant mice. Interestingly, this treatment had little or no effect on parasite numbers in the lesions or on the cytokines (interferon-gamma, interleukin-4) that the animals produced in response to infection with the parasite. These results suggest that although IL-1 plays a detrimental role in cutaneous leishmaniasis, it does not mediate this effect by altering the parasite-specific T cell response." @default.
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• W2056513494 date "1994-11-01" @default.
• W2056513494 modified "2023-09-24" @default.
• W2056513494 title "The effect of treating with anti-interleukin-1 receptor antibody on the course of experimental murine cutaneous leishmaniasis" @default.
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• W2056513494 doi "https://doi.org/10.1111/j.1365-3024.1994.tb00312.x" @default.
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