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• W2056514314 endingPage "417" @default.
• W2056514314 startingPage "408" @default.
• W2056514314 abstract "Using patch-clamp techniques, we studied the plasticity of acid-sensing ion channels (ASIC) and transient receptor potential V1 (TRPV1) channel function in dorsal root ganglia (DRG) neurons retrogradely labeled from the bladder. Saline (control) or cyclophosphamide (CYP) was given intraperitoneally on days 1, 3, and 5. On day 6, lumbosacral (LS, L6–S2) or thoracolumbar (TL, T13–L2) DRG were removed and dissociated. Bladders and bladder DRG neurons from CYP-treated rats showed signs of inflammation (greater myeloperoxidase activity; lower intramuscular wall pH) and increased size (whole cell capacitance), respectively, compared with controls. Most bladder neurons (>90%) responded to protons and capsaicin. Protons produced multiphasic currents with distinct kinetics, whereas capsaicin always triggered a sustained response. The TRPV1 receptor antagonist A-425619 abolished capsaicin-triggered currents and raised the threshold of heat-activated currents. Prolonged exposure to an acidic environment (pH range: 7.2 to 6.6) inhibited proton-evoked currents, potentiated the capsaicin-evoked current, and reduced the threshold of heat-activated currents in LS and TL bladder neurons. CYP treatment reduced density but not kinetics of all current components triggered by pH 5. In contrast, CYP-treatment was associated with an increased current density in response to capsaicin in LS and TL bladder neurons. Correspondingly, heat triggered current at a significantly lower temperature in bladder neurons from CYP-treated rats compared with controls. These results reveal that cystitis differentially affects TRPV1- and ASIC-mediated currents in both bladder sensory pathways. Acidification of the bladder wall during inflammation may contribute to changes in nociceptive transmission mediated through the TRPV1 receptor, suggesting a role for TRPV1 in hypersensitivity associated with cystitis." @default.
• W2056514314 created "2016-06-24" @default.
• W2056514314 creator A5024503316 @default.
• W2056514314 creator A5027305249 @default.
• W2056514314 creator A5047846623 @default.
• W2056514314 date "2013-07-15" @default.
• W2056514314 modified "2023-10-01" @default.
• W2056514314 title "Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons" @default.
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• W2056514314 doi "https://doi.org/10.1152/jn.00945.2012" @default.
• W2056514314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3727072" @default.
• W2056514314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23636721" @default.
• W2056514314 hasPublicationYear "2013" @default.
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