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• W2056514659 abstract "Diallyldisulfide (DADS), an active principle of garlic (Allium sativum) is known for its antihyperlipidemic properties. The present study was designed to evaluate the effect of novel synthesized DADS analogs, on the lipid profile of hypercholesterolemic rats and to investigate the molecular correlates of their activity at the cellular level. Wistar rats, weighing 100–120 g each, were administered with 5% cholesterol for one week, and subsequently administered with lovastatin, allicin and DADS (20 mg/kg wt) analogs in the second week along with 5% cholesterol. All animals were sacrificed after overnight starvation. Our results show that DADS analogs are effective in reducing the total lipid levels which could be correlated with a significant decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. DADS analogs strongly inhibit HMGR activity in vivo but not in vitro. These results can be attributed to the significant decrease in the mRNA levels and protein expression of HMGR. Further, we show that DADS analogs significantly inhibited the activation of sterol regulatory element-binding protein-2 (SREBP-2) and interfered with DNA binding activity of cAMP response element-binding protein (CREB) but not nuclear factor-Y (NF-Y), with upstream regulatory sequences of HMGR. Moreover, DADS analogs are also effective in reducing the levels of oxidized low-density lipoprotein (ox-LDL), lipid peroxidation as well as NF-κB activity, showing good anti-inflammatory and antioxidant properties. The unique anti-inflammatory effect and hypolipidemic action of DADS analogs may be beneficial in preventing the vascular complications that are induced by hyperlipidemia and provide a new therapeutic approach for the treatment of cardiovascular and related diseases." @default.
• W2056514659 created "2016-06-24" @default.
• W2056514659 creator A5003511135 @default.
• W2056514659 creator A5043315369 @default.
• W2056514659 creator A5052679327 @default.
• W2056514659 date "2009-07-01" @default.
• W2056514659 modified "2023-09-25" @default.
• W2056514659 title "Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target" @default.
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• W2056514659 doi "https://doi.org/10.1016/j.lfs.2009.05.020" @default.
• W2056514659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19523964" @default.
• W2056514659 hasPublicationYear "2009" @default.
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