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• W2056515148 endingPage "344" @default.
• W2056515148 startingPage "337" @default.
• W2056515148 abstract "The LTRs of HIV-1 and HTLV-I have been shown by several laboratories to be activated by 12-O-tetradecanoylphorbol-13-acetate (TPA). This agent is a potent activator of protein kinase C (PKC). However, long exposure to TPA downregulates PKC in many cell types. We demonstrated that TPA treatment of Jurkat cells for more than 24 hr resulted in a sever depletion of this enzyme. Therefore, to explore the role of PKC in the effect of TPA on these LTRs, we transfected Jurkat cells with HIV-1 LTR-CAT or HTLV-I LTR-CAT construct after 72 hr of TPA pretreatment. While this TPA pretreatment considerably reduced the HIV-1 LTR basal expression, it strongly stimulated the expression of HTLV-I LTR. Furthermore, when TPA was added after transfection, a strong stimulation of HIV-1 LTR was observed, which could be abrogated by PKC inhibitors like H7 and chelerythryn. However, under these conditions TPA stimulated HTLV-I LTR to a lesser extent than did the long-term TPA pretreatment. Moreover, this stimulation was enhanced by the PKC inhibitors. Thus our data indicate that while the effect of TPA on HIV-1 LTR is strictly dependent on PKC activity, its effect on HTLV-I LTR is exerted via a different pathway that not only does not require PKC activation but rather seems to be antagonized by the activated PKC. Using a deletion mutant of HTLV-I LTR we mapped the PKC-independent effect of TPA to the c-ets responsive region 1 (ERR-1) located in U3 of this LTR." @default.
• W2056515148 created "2016-06-24" @default.
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• W2056515148 date "1997-06-01" @default.
• W2056515148 modified "2023-09-28" @default.
• W2056515148 title "The Long Terminal Repeats of Human Immunodeficiency Virus Type-1 and Human T-cell Leukemia Virus Type-I Are Activated by 12-O-Tetradecanoylphorbol- 13-acetate through Different Pathways" @default.
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• W2056515148 doi "https://doi.org/10.1006/viro.1997.8566" @default.
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