Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056515539> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2056515539 endingPage "2530" @default.
- W2056515539 startingPage "2521" @default.
- W2056515539 abstract "Activation of protease-activated receptor-1 (PAR-1) produces a dual action, apamin-sensitive relaxation followed by contraction, in the rat duodenal smooth muscle, which is partially dependent on activation of L-type Ca2+ channels, protein kinase C (PKC) or tyrosine kinase (TK), and resistant to tetrodotoxin. The present study further characterized the PAR-1-mediated duodenal responses. Removal of extracellular Ca2+ as well as SK&F96365 reduced the contraction due to the PAR-1 agonist TFLLR-NH2 (TFp-NH2) by 60-80% that was similar to the extent of the inhibition by nifedipine. Lowering of the extracellular Na+ concentration, but not IAA-94, a Cl- channel inhibitor, reduced both the PAR-1-mediated contraction and relaxation by about 50%. U73122, a phospholipase C (PLC) inhibitor, or wortmannin, a phosphatidyl inositol 3'-kinase (PI3K) inhibitor, significantly reduced the PAR-1-mediated contraction, but not the relaxation, by itself, as the PKC inhibitor GF109203X and the TK inhibitor genistein did. U73122 or wortmannin, like GF109203X, when applied in combination with genistein, significantly reduced the PAR-1-mediated relaxation. The relaxation was resistant to antagonists of PACAP receptors, VIP receptors and P2 purinoceptors. Thus, the PAR-1-mediated contraction is considered to be dependent on intracellular and extracellular Ca2+, the influx of the latter being induced through activation of L-type Ca2+ channels triggered by the enhanced Na+ permeability, and that PLC and PI3K, in addition to PKC and TK, are involved in the PAR-1-mediated dual responses. Furthermore, non-adrenergic, non-cholinergic nerve neurotransmitter candidates that may modulate K+ channels do not appear to contribute to the relaxation by PAR-1 activation." @default.
- W2056515539 created "2016-06-24" @default.
- W2056515539 creator A5022680842 @default.
- W2056515539 creator A5031334106 @default.
- W2056515539 creator A5039950300 @default.
- W2056515539 creator A5044229650 @default.
- W2056515539 creator A5050276095 @default.
- W2056515539 creator A5066568088 @default.
- W2056515539 date "2000-10-01" @default.
- W2056515539 modified "2023-10-05" @default.
- W2056515539 title "Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle" @default.
- W2056515539 doi "https://doi.org/10.1016/s0024-3205(00)00835-3" @default.
- W2056515539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11065174" @default.
- W2056515539 hasPublicationYear "2000" @default.
- W2056515539 type Work @default.
- W2056515539 sameAs 2056515539 @default.
- W2056515539 citedByCount "30" @default.
- W2056515539 countsByYear W20565155392014 @default.
- W2056515539 countsByYear W20565155392015 @default.
- W2056515539 countsByYear W20565155392016 @default.
- W2056515539 countsByYear W20565155392018 @default.
- W2056515539 countsByYear W20565155392019 @default.
- W2056515539 countsByYear W20565155392023 @default.
- W2056515539 crossrefType "journal-article" @default.
- W2056515539 hasAuthorship W2056515539A5022680842 @default.
- W2056515539 hasAuthorship W2056515539A5031334106 @default.
- W2056515539 hasAuthorship W2056515539A5039950300 @default.
- W2056515539 hasAuthorship W2056515539A5044229650 @default.
- W2056515539 hasAuthorship W2056515539A5050276095 @default.
- W2056515539 hasAuthorship W2056515539A5066568088 @default.
- W2056515539 hasConcept C12554922 @default.
- W2056515539 hasConcept C126322002 @default.
- W2056515539 hasConcept C134018914 @default.
- W2056515539 hasConcept C163415756 @default.
- W2056515539 hasConcept C170493617 @default.
- W2056515539 hasConcept C185592680 @default.
- W2056515539 hasConcept C195794163 @default.
- W2056515539 hasConcept C2776919887 @default.
- W2056515539 hasConcept C2778308172 @default.
- W2056515539 hasConcept C2778597717 @default.
- W2056515539 hasConcept C2780610907 @default.
- W2056515539 hasConcept C28406088 @default.
- W2056515539 hasConcept C55493867 @default.
- W2056515539 hasConcept C62478195 @default.
- W2056515539 hasConcept C71924100 @default.
- W2056515539 hasConcept C83743174 @default.
- W2056515539 hasConcept C86803240 @default.
- W2056515539 hasConcept C95444343 @default.
- W2056515539 hasConceptScore W2056515539C12554922 @default.
- W2056515539 hasConceptScore W2056515539C126322002 @default.
- W2056515539 hasConceptScore W2056515539C134018914 @default.
- W2056515539 hasConceptScore W2056515539C163415756 @default.
- W2056515539 hasConceptScore W2056515539C170493617 @default.
- W2056515539 hasConceptScore W2056515539C185592680 @default.
- W2056515539 hasConceptScore W2056515539C195794163 @default.
- W2056515539 hasConceptScore W2056515539C2776919887 @default.
- W2056515539 hasConceptScore W2056515539C2778308172 @default.
- W2056515539 hasConceptScore W2056515539C2778597717 @default.
- W2056515539 hasConceptScore W2056515539C2780610907 @default.
- W2056515539 hasConceptScore W2056515539C28406088 @default.
- W2056515539 hasConceptScore W2056515539C55493867 @default.
- W2056515539 hasConceptScore W2056515539C62478195 @default.
- W2056515539 hasConceptScore W2056515539C71924100 @default.
- W2056515539 hasConceptScore W2056515539C83743174 @default.
- W2056515539 hasConceptScore W2056515539C86803240 @default.
- W2056515539 hasConceptScore W2056515539C95444343 @default.
- W2056515539 hasIssue "20" @default.
- W2056515539 hasLocation W20565155391 @default.
- W2056515539 hasLocation W20565155392 @default.
- W2056515539 hasOpenAccess W2056515539 @default.
- W2056515539 hasPrimaryLocation W20565155391 @default.
- W2056515539 hasRelatedWork W1996846474 @default.
- W2056515539 hasRelatedWork W2018368842 @default.
- W2056515539 hasRelatedWork W2031737195 @default.
- W2056515539 hasRelatedWork W2033472167 @default.
- W2056515539 hasRelatedWork W2034583712 @default.
- W2056515539 hasRelatedWork W2063619316 @default.
- W2056515539 hasRelatedWork W2112223211 @default.
- W2056515539 hasRelatedWork W2123057090 @default.
- W2056515539 hasRelatedWork W2169225653 @default.
- W2056515539 hasRelatedWork W2414846389 @default.
- W2056515539 hasVolume "67" @default.
- W2056515539 isParatext "false" @default.
- W2056515539 isRetracted "false" @default.
- W2056515539 magId "2056515539" @default.
- W2056515539 workType "article" @default.