FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056516431> ?p ?o ?g. }

• W2056516431 endingPage "323" @default.
• W2056516431 startingPage "319" @default.
• W2056516431 abstract "Surfactants are used to prevent the irreversible aggregation of partially refolded proteins and they also assist in protein refolding. We have reported the design and screening of gemini surfactant to stabilize bovine serum albumin (BSA) with the help of computational tool (iGEMDOCK). A series of gemini surfactant has been designed based on bis-N-alkyl nicotinate dianion via varying the alkyl group and anion. On changing the alkyl group and anion of the surfactant, the value of Log P changes means polarity of surfactant can be tuned. Further, the virtual screening of the gemini surfactant has been carried out based on generic evolutionary method. Herein, thermodynamic data was studied to determine the potential of gemini surfactant as BSA stabilizer. Computational tools help to find out the efficient gemini surfactant to stabilize the BSA rather than to use the surfactant randomly and directionless for the stabilization. It can be confirmed through the experimental techniques. Previously, researcher synthesized one of the designed and used gemini surfactant to stabilize the BSA and their interactions were confirmed through various techniques and computational docking. But herein, the authors find the most competent gemini surfactant to stabilize BSA using computational tools on the basis of energy score. Different from the single chain surfactant, the gemini surfactants exhibit much stronger electrostatic and hydrophobic interactions with the protein and are thus effective at much lower concentrations. Based on the present study, it is expected that gemini surfactants may prove useful in the protein stabilization operations and may thus be effectively employed to circumvent the problem of misfolding and aggregation." @default.
• W2056516431 created "2016-06-24" @default.
• W2056516431 creator A5011892484 @default.
• W2056516431 creator A5024560018 @default.
• W2056516431 creator A5032045921 @default.
• W2056516431 creator A5052149227 @default.
• W2056516431 creator A5054678939 @default.
• W2056516431 creator A5063288941 @default.
• W2056516431 creator A5067200102 @default.
• W2056516431 creator A5087479315 @default.
• W2056516431 date "2015-05-01" @default.
• W2056516431 modified "2023-09-24" @default.
• W2056516431 title "Theoretical model to investigate the alkyl chain and anion dependent interactions of gemini surfactant with bovine serum albumin" @default.
• W2056516431 cites W1513938578 @default.
• W2056516431 cites W1964153187 @default.
• W2056516431 cites W1967362126 @default.
• W2056516431 cites W1976939054 @default.
• W2056516431 cites W1980296502 @default.
• W2056516431 cites W1986188860 @default.
• W2056516431 cites W1988671383 @default.
• W2056516431 cites W2000821369 @default.
• W2056516431 cites W2002712354 @default.
• W2056516431 cites W2017027704 @default.
• W2056516431 cites W2018943698 @default.
• W2056516431 cites W2062429004 @default.
• W2056516431 cites W2065773282 @default.
• W2056516431 cites W2077168300 @default.
• W2056516431 cites W2088317258 @default.
• W2056516431 cites W2131692566 @default.
• W2056516431 cites W2132086382 @default.
• W2056516431 cites W2312232475 @default.
• W2056516431 cites W2334555086 @default.
• W2056516431 cites W46997909 @default.
• W2056516431 doi "https://doi.org/10.1016/j.saa.2015.01.068" @default.
• W2056516431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25766242" @default.
• W2056516431 hasPublicationYear "2015" @default.
• W2056516431 type Work @default.
• W2056516431 sameAs 2056516431 @default.
• W2056516431 citedByCount "20" @default.
• W2056516431 countsByYear W20565164312015 @default.
• W2056516431 countsByYear W20565164312017 @default.
• W2056516431 countsByYear W20565164312019 @default.
• W2056516431 countsByYear W20565164312020 @default.
• W2056516431 countsByYear W20565164312021 @default.
• W2056516431 countsByYear W20565164312022 @default.
• W2056516431 crossrefType "journal-article" @default.
• W2056516431 hasAuthorship W2056516431A5011892484 @default.
• W2056516431 hasAuthorship W2056516431A5024560018 @default.
• W2056516431 hasAuthorship W2056516431A5032045921 @default.
• W2056516431 hasAuthorship W2056516431A5052149227 @default.
• W2056516431 hasAuthorship W2056516431A5054678939 @default.
• W2056516431 hasAuthorship W2056516431A5063288941 @default.
• W2056516431 hasAuthorship W2056516431A5067200102 @default.
• W2056516431 hasAuthorship W2056516431A5087479315 @default.
• W2056516431 hasConcept C127413603 @default.
• W2056516431 hasConcept C178790620 @default.
• W2056516431 hasConcept C185592680 @default.
• W2056516431 hasConcept C2780263894 @default.
• W2056516431 hasConcept C42360764 @default.
• W2056516431 hasConcept C43617362 @default.
• W2056516431 hasConcept C55493867 @default.
• W2056516431 hasConcept C58226133 @default.
• W2056516431 hasConcept C86807702 @default.
• W2056516431 hasConceptScore W2056516431C127413603 @default.
• W2056516431 hasConceptScore W2056516431C178790620 @default.
• W2056516431 hasConceptScore W2056516431C185592680 @default.
• W2056516431 hasConceptScore W2056516431C2780263894 @default.
• W2056516431 hasConceptScore W2056516431C42360764 @default.
• W2056516431 hasConceptScore W2056516431C43617362 @default.
• W2056516431 hasConceptScore W2056516431C55493867 @default.
• W2056516431 hasConceptScore W2056516431C58226133 @default.
• W2056516431 hasConceptScore W2056516431C86807702 @default.
• W2056516431 hasLocation W20565164311 @default.
• W2056516431 hasLocation W20565164312 @default.
• W2056516431 hasOpenAccess W2056516431 @default.
• W2056516431 hasPrimaryLocation W20565164311 @default.
• W2056516431 hasRelatedWork W1974496386 @default.
• W2056516431 hasRelatedWork W2007535035 @default.
• W2056516431 hasRelatedWork W2082989531 @default.
• W2056516431 hasRelatedWork W2087761197 @default.
• W2056516431 hasRelatedWork W2402972497 @default.
• W2056516431 hasRelatedWork W2748952813 @default.
• W2056516431 hasRelatedWork W2949226516 @default.
• W2056516431 hasRelatedWork W2949404879 @default.
• W2056516431 hasRelatedWork W2952979462 @default.
• W2056516431 hasRelatedWork W3118569898 @default.
• W2056516431 hasVolume "143" @default.
• W2056516431 isParatext "false" @default.
• W2056516431 isRetracted "false" @default.
• W2056516431 magId "2056516431" @default.
• W2056516431 workType "article" @default.