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- W2056516454 abstract "Abstract When fed simultaneously, β-naphthylisothiocyanate (BNIT) inhibits p-dimethylaminoazobenzene (DAB)-induced hepatocarcinogenesis in rats. This investigation was designed to elucidate the effects of continuous BNIT feeding on liver function, especially with respect to the xenobiotic metabolizing system. Male F-344 rats were fed BNIT at 0.022, 0.047, and 0.1% of the diet for 4 weeks. Light microscopic evaluation of liver sections only revealed alterations in the 0.1% group, where multifocal granulomatous inflammatory lesions were present. No changes in liver-derived serum enzymes and serum bilirubin were detected in any dose group. Treatment with BNIT caused dose-dependent increases in hepatic cytochrome P-450, ethoxycoumarin-O-deethylase activity, and benzphetamine-N-demethylase activity. BNIT also stimulated DT-diaphorase activity but did not alter epoxide hydrolase activity. These results are in sharp contrast to those of a related compound, α-naphthylisothiocyanate (ANIT), which also inhibits chemical carcinogenesis. At similar doses and time intervals ANIT decreases cytochrome P-450 and related enzymes and causes marked increases in epoxide hydrolase and DT-diaphorase. These observations support the hypothesis that enhanced drug metabolism, particularly elevated azo reduction, may explain the inhibition of DAB hepatocarcinogenesis by BNIT." @default.
- W2056516454 created "2016-06-24" @default.
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- W2056516454 date "1981-09-01" @default.
- W2056516454 modified "2023-10-18" @default.
- W2056516454 title "?-naphthylisothiocyanate-induced alterations in hepatic drug metabolism and liver morphology" @default.
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- W2056516454 doi "https://doi.org/10.1016/0041-008x(81)90339-2" @default.
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