FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056518174> ?p ?o ?g. }

• W2056518174 endingPage "2086" @default.
• W2056518174 startingPage "2073" @default.
• W2056518174 abstract "Control over angiogenesis (formation of new capillaries from preexisting vessels) is often a crucial requirement for implantable porous biomaterials serving as scaffolds for tissue regeneration. Angiogenesis is influenced by the transport of chemoattractants such as vascular endothelial growth factor (VEGF) through the implant. To investigate this influence, we developed a computational model of capillary formation based on endothelial cell migration by modeling the random motion of sprout tips biased along spatially and temporally evolving concentration gradients of VEGF. The model focuses on the effect of diffusive VEGF transport inside a 2D domain on the directed migration of sprouts to test several chemical and physical strategies to stimulate and control angiogenesis. We considered a 2D porous membrane that is located between the primary vessel and a line source of VEGF. We assess the vascular network formed in 2 cases of a high and zero VEGF degradation rates applying 3 strategies of VEGF production: (1) only a line source; (2) a line source plus controlled release from a small number of VEGF sources that are randomly dispersed on the pore boundaries; and (3) a line source plus controlled release of VEGF from the pore boundaries themselves. Results show that in the limiting cases where VEGF degradation rate is relatively high, strategies 2 and 3 lead to a substantial increase in the number of vessels. This increase depends on the relative rates at which the line source and embedded sources or solid boundaries produce VEGF. Using strategy 2 results in a newly formed capillary network that is highly localized around the embedded sources. However, using strategy 3 leads to a more uniformly distributed vessel network and a higher degree of vessel ingrowth inside the porous membrane. In addition, the duration at which we engineer the embedded sources or pore boundaries to release VEGF determines the morphology of the capillary network. Although a higher release duration leads to a dense network of newly formed vessels near the primary vessel, it hinders further vessel penetration inside the porous membrane. Therefore, in applying both strategies 2 and 3, there is an optimum release duration that leads to a deeper penetration of vessels inside the membrane. It is hoped that insights from this study will aid in the design of materials with optimal structural and chemical properties to facilitate controlled angiogenesis." @default.
• W2056518174 created "2016-06-24" @default.
• W2056518174 creator A5036648113 @default.
• W2056518174 creator A5038508476 @default.
• W2056518174 date "2007-08-01" @default.
• W2056518174 modified "2023-09-24" @default.
• W2056518174 title "Strategies to Enhance Capillary Formation Inside Biomaterials: A Computational Study" @default.
• W2056518174 cites W1679229092 @default.
• W2056518174 cites W168158090 @default.
• W2056518174 cites W1967265143 @default.
• W2056518174 cites W1976553848 @default.
• W2056518174 cites W1976907471 @default.
• W2056518174 cites W1995576889 @default.
• W2056518174 cites W1996367182 @default.
• W2056518174 cites W1996709540 @default.
• W2056518174 cites W1999876918 @default.
• W2056518174 cites W2018589752 @default.
• W2056518174 cites W2019971252 @default.
• W2056518174 cites W2045962560 @default.
• W2056518174 cites W2062796205 @default.
• W2056518174 cites W2066985666 @default.
• W2056518174 cites W2074259186 @default.
• W2056518174 cites W2078529125 @default.
• W2056518174 cites W2081703144 @default.
• W2056518174 cites W2082157250 @default.
• W2056518174 cites W2086335524 @default.
• W2056518174 cites W2086683565 @default.
• W2056518174 cites W2090717631 @default.
• W2056518174 cites W2092145659 @default.
• W2056518174 cites W2095423829 @default.
• W2056518174 cites W2095595785 @default.
• W2056518174 cites W2102890509 @default.
• W2056518174 cites W2112587095 @default.
• W2056518174 cites W2131019734 @default.
• W2056518174 cites W2135799863 @default.
• W2056518174 cites W2137390239 @default.
• W2056518174 cites W2138992193 @default.
• W2056518174 cites W2154157809 @default.
• W2056518174 cites W2155121261 @default.
• W2056518174 cites W2341075143 @default.
• W2056518174 doi "https://doi.org/10.1089/ten.2006.0057" @default.
• W2056518174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17590150" @default.
• W2056518174 hasPublicationYear "2007" @default.
• W2056518174 type Work @default.
• W2056518174 sameAs 2056518174 @default.
• W2056518174 citedByCount "20" @default.
• W2056518174 countsByYear W20565181742012 @default.
• W2056518174 countsByYear W20565181742013 @default.
• W2056518174 countsByYear W20565181742015 @default.
• W2056518174 crossrefType "journal-article" @default.
• W2056518174 hasAuthorship W2056518174A5036648113 @default.
• W2056518174 hasAuthorship W2056518174A5038508476 @default.
• W2056518174 hasConcept C12554922 @default.
• W2056518174 hasConcept C127413603 @default.
• W2056518174 hasConcept C136229726 @default.
• W2056518174 hasConcept C159985019 @default.
• W2056518174 hasConcept C167734588 @default.
• W2056518174 hasConcept C185592680 @default.
• W2056518174 hasConcept C192562407 @default.
• W2056518174 hasConcept C196806460 @default.
• W2056518174 hasConcept C2777025900 @default.
• W2056518174 hasConcept C2780394083 @default.
• W2056518174 hasConcept C502942594 @default.
• W2056518174 hasConcept C86803240 @default.
• W2056518174 hasConceptScore W2056518174C12554922 @default.
• W2056518174 hasConceptScore W2056518174C127413603 @default.
• W2056518174 hasConceptScore W2056518174C136229726 @default.
• W2056518174 hasConceptScore W2056518174C159985019 @default.
• W2056518174 hasConceptScore W2056518174C167734588 @default.
• W2056518174 hasConceptScore W2056518174C185592680 @default.
• W2056518174 hasConceptScore W2056518174C192562407 @default.
• W2056518174 hasConceptScore W2056518174C196806460 @default.
• W2056518174 hasConceptScore W2056518174C2777025900 @default.
• W2056518174 hasConceptScore W2056518174C2780394083 @default.
• W2056518174 hasConceptScore W2056518174C502942594 @default.
• W2056518174 hasConceptScore W2056518174C86803240 @default.
• W2056518174 hasIssue "8" @default.
• W2056518174 hasLocation W20565181741 @default.
• W2056518174 hasLocation W20565181742 @default.
• W2056518174 hasOpenAccess W2056518174 @default.
• W2056518174 hasPrimaryLocation W20565181741 @default.
• W2056518174 hasRelatedWork W1164293911 @default.
• W2056518174 hasRelatedWork W1550975546 @default.
• W2056518174 hasRelatedWork W2000187563 @default.
• W2056518174 hasRelatedWork W2007495049 @default.
• W2056518174 hasRelatedWork W2007547100 @default.
• W2056518174 hasRelatedWork W2015285162 @default.
• W2056518174 hasRelatedWork W2043618129 @default.
• W2056518174 hasRelatedWork W2368639167 @default.
• W2056518174 hasRelatedWork W2394100026 @default.
• W2056518174 hasRelatedWork W3208607827 @default.
• W2056518174 hasVolume "13" @default.
• W2056518174 isParatext "false" @default.
• W2056518174 isRetracted "false" @default.
• W2056518174 magId "2056518174" @default.
• W2056518174 workType "article" @default.