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• W2056519855 abstract "Defective thymic egress in mice is associated with the peripheral T cell deficiency (Ptcd) locus. Cyster and colleagues find that the actin regulator coronin 1A is mutant in Ptcd and in an atypical patient with SCID. Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. Here we found that Ptcd T cells had an intrinsic migration defect, impaired lymphoid tissue trafficking and irregularly shaped protrusions. Characterization of the Ptcd locus showed a point substitution of lysine for glutamic acid at position 26 in the actin regulator coronin 1A that enhanced its inhibition of the actin regulator Arp2/3 and resulted in its mislocalization from the leading edge of migrating T cells. The discovery of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell–lymphopenic mice prompted us to evaluate a T cell–deficient, B cell–sufficient and natural killer cell–sufficient patient with severe combined immunodeficiency, whom we found had mutations in both CORO1A alleles. Our findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation and demonstrate that actin regulation is a biological process defective in human and mouse severe combined immunodeficiency." @default.
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• W2056519855 date "2008-10-05" @default.
• W2056519855 modified "2023-10-18" @default.
• W2056519855 title "The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency" @default.
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• W2056519855 doi "https://doi.org/10.1038/ni.1662" @default.
• W2056519855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2672406" @default.
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