FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056520311> ?p ?o ?g. }

• W2056520311 endingPage "468" @default.
• W2056520311 startingPage "454" @default.
• W2056520311 abstract "A bstract : Humans subjected to prolonged periods of bed rest or microgravity undergo deconditioning of the cardiovascular system, characterized by resting tachycardia, reduced exercise capability, and a predisposition for orthostatic intolerance. These changes in cardiovascular function are likely due to a combination of factors, including changes in control of body fluid balance or cardiac alterations resulting in inadequate maintenance of stroke volume, altered arterial or venous vascular function, reduced activation of cardiovascular hormones, and diminished autonomic reflex function. There is evidence indicating a role for each of these mechanisms. Diminished reflex activation of the sympathetic nervous system and subsequent vasoconstriction appear to play an important role. Studies utilizing the hindlimb‐unloaded (HU) rat, an animal model of deconditioning, evaluated the potential role of altered arterial baroreflex control of the sympathetic nervous system. These studies indicate that HU results in blunted baroreflex‐mediated activation of both renal and lumbar sympathetic nerve activity in response to a hypotensive stimulus. HU rats are less able to maintain arterial pressure during hemorrhage, suggesting that diminished ability to increase sympathetic activity has functional consequences for the animal. Reflex control of vasopressin secretion appears to be enhanced following HU. Blunted baroreflex‐mediated sympathoexcitation appears to involve altered central nervous system function. Baroreceptor afferent activity in response to changes in arterial pressure is unaltered in HU rats. However, increases in efferent sympathetic nerve activity for a given decrease in afferent input are blunted after HU. This altered central nervous system processing of baroreceptor inputs appears to involve an effect at the rostral ventrolateral medulla (RVLM). Specifically, it appears that tonic GABA A ‐mediated inhibition of the RVLM is enhanced after HU. Augmented inhibition apparently arises from sources other than the caudal ventrolateral medulla. If similar alterations in control of the sympathetic nervous system occur in humans in response to cardiovascular deconditioning, it is likely that they play an important role in the observed tendency for orthostatic intolerance. Combined with potential changes in vascular function, cardiac function, and hypovolemia, the predisposition for orthostatic intolerance following cardiovascular deconditioning would be markedly enhanced by blunted ability to reflexly activate the sympathetic nervous system." @default.
• W2056520311 created "2016-06-24" @default.
• W2056520311 creator A5048751156 @default.
• W2056520311 creator A5085838697 @default.
• W2056520311 date "2001-06-01" @default.
• W2056520311 modified "2023-10-15" @default.
• W2056520311 title "Regulation of Sympathetic Nervous System Function after Cardiovascular Deconditioning" @default.
• W2056520311 cites W1502754895 @default.
• W2056520311 cites W1507297596 @default.
• W2056520311 cites W1573635199 @default.
• W2056520311 cites W1836925387 @default.
• W2056520311 cites W1852131826 @default.
• W2056520311 cites W1873658666 @default.
• W2056520311 cites W1900969011 @default.
• W2056520311 cites W1914927129 @default.
• W2056520311 cites W1943576895 @default.
• W2056520311 cites W1961234784 @default.
• W2056520311 cites W1971959365 @default.
• W2056520311 cites W2007778320 @default.
• W2056520311 cites W2008422220 @default.
• W2056520311 cites W2019943178 @default.
• W2056520311 cites W2022636360 @default.
• W2056520311 cites W2046198960 @default.
• W2056520311 cites W2062414497 @default.
• W2056520311 cites W2073106478 @default.
• W2056520311 cites W2094875635 @default.
• W2056520311 cites W2096512275 @default.
• W2056520311 cites W2104361200 @default.
• W2056520311 cites W2130605767 @default.
• W2056520311 cites W2131176481 @default.
• W2056520311 cites W2141094728 @default.
• W2056520311 cites W2174230871 @default.
• W2056520311 cites W2176720521 @default.
• W2056520311 cites W2183837987 @default.
• W2056520311 cites W2219705225 @default.
• W2056520311 cites W2263287739 @default.
• W2056520311 cites W2285852900 @default.
• W2056520311 cites W2290524033 @default.
• W2056520311 cites W2300094329 @default.
• W2056520311 cites W2301668395 @default.
• W2056520311 cites W2393589412 @default.
• W2056520311 cites W2400552324 @default.
• W2056520311 cites W255700 @default.
• W2056520311 doi "https://doi.org/10.1111/j.1749-6632.2001.tb03698.x" @default.
• W2056520311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11458701" @default.
• W2056520311 hasPublicationYear "2001" @default.
• W2056520311 type Work @default.
• W2056520311 sameAs 2056520311 @default.
• W2056520311 citedByCount "57" @default.
• W2056520311 countsByYear W20565203112012 @default.
• W2056520311 countsByYear W20565203112013 @default.
• W2056520311 countsByYear W20565203112015 @default.
• W2056520311 countsByYear W20565203112016 @default.
• W2056520311 countsByYear W20565203112017 @default.
• W2056520311 countsByYear W20565203112018 @default.
• W2056520311 countsByYear W20565203112019 @default.
• W2056520311 countsByYear W20565203112020 @default.
• W2056520311 countsByYear W20565203112021 @default.
• W2056520311 countsByYear W20565203112022 @default.
• W2056520311 countsByYear W20565203112023 @default.
• W2056520311 crossrefType "journal-article" @default.
• W2056520311 hasAuthorship W2056520311A5048751156 @default.
• W2056520311 hasAuthorship W2056520311A5085838697 @default.
• W2056520311 hasConcept C126322002 @default.
• W2056520311 hasConcept C134018914 @default.
• W2056520311 hasConcept C191237925 @default.
• W2056520311 hasConcept C19383871 @default.
• W2056520311 hasConcept C2776533406 @default.
• W2056520311 hasConcept C2777152909 @default.
• W2056520311 hasConcept C2777372248 @default.
• W2056520311 hasConcept C2777953023 @default.
• W2056520311 hasConcept C2779624417 @default.
• W2056520311 hasConcept C529278444 @default.
• W2056520311 hasConcept C71924100 @default.
• W2056520311 hasConcept C79752029 @default.
• W2056520311 hasConcept C83974742 @default.
• W2056520311 hasConcept C84393581 @default.
• W2056520311 hasConceptScore W2056520311C126322002 @default.
• W2056520311 hasConceptScore W2056520311C134018914 @default.
• W2056520311 hasConceptScore W2056520311C191237925 @default.
• W2056520311 hasConceptScore W2056520311C19383871 @default.
• W2056520311 hasConceptScore W2056520311C2776533406 @default.
• W2056520311 hasConceptScore W2056520311C2777152909 @default.
• W2056520311 hasConceptScore W2056520311C2777372248 @default.
• W2056520311 hasConceptScore W2056520311C2777953023 @default.
• W2056520311 hasConceptScore W2056520311C2779624417 @default.
• W2056520311 hasConceptScore W2056520311C529278444 @default.
• W2056520311 hasConceptScore W2056520311C71924100 @default.
• W2056520311 hasConceptScore W2056520311C79752029 @default.
• W2056520311 hasConceptScore W2056520311C83974742 @default.
• W2056520311 hasConceptScore W2056520311C84393581 @default.
• W2056520311 hasIssue "1" @default.
• W2056520311 hasLocation W20565203111 @default.
• W2056520311 hasLocation W20565203112 @default.
• W2056520311 hasOpenAccess W2056520311 @default.
• W2056520311 hasPrimaryLocation W20565203111 @default.
• W2056520311 hasRelatedWork W1968283343 @default.
• W2056520311 hasRelatedWork W2063248105 @default.

• next