FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056520707> ?p ?o ?g. }

• W2056520707 endingPage "444" @default.
• W2056520707 startingPage "438" @default.
• W2056520707 abstract "Abstract Mannose‐binding lectin (MBL) insufficiency caused by point mutations in the MBL2 gene has been associated with increased susceptibility to bacteraemic infections. We here investigated the effect of MBL2 polymorphisms on the susceptibility and clinical course of bacteraemia. The study cohort comprised 145 patients with bacteraemia and 400 controls. In the case of patients with bacteraemia, laboratory findings and clinical data were registered on admission and during six consecutive days. MBL2 structural polymorphisms at codons 52 (CGT→TGT; designated D or O), 54 (GGC→GAC; B or O) and 57 (GGA→GAA; C or O) in exon 1 of the MBL2 gene and promoter region polymorphisms at position −221 (G→C, designated Y or X alleles) were determined. No difference in MBL2 genotype frequencies between the bacteraemic patients and controls was detected, and MBL2 genotype had no independent effect on mortality, nor disease severity. However, smoking proved a significant risk factor for Gram‐positive ( Staphylococcus aureus , Streptococcus pneumoniae or β‐haemolytic streptococci) bacteraemia in patients carrying the variant O allele (53% current smokers in Gram‐positive bacteraemia patients compared with only 21% in controls, odds ratios 4.2, 95% confidence intervals 2.0–9.0; P < 0.001), while it did not have an effect in those homozygous for the A allele. The same effect was not detected in Escherichia coli bacteraemia. In conclusion, MBL2 genotypes representing MBL insufficiency were not associated with the overall risk of bacteraemia or disease severity, but smoking in carriers of the structural variant O allele may have a deleterious effect increasing the risk of Gram‐positive bacteraemia." @default.
• W2056520707 created "2016-06-24" @default.
• W2056520707 creator A5024481694 @default.
• W2056520707 creator A5040554257 @default.
• W2056520707 creator A5042344507 @default.
• W2056520707 creator A5047174566 @default.
• W2056520707 creator A5047519153 @default.
• W2056520707 creator A5053371659 @default.
• W2056520707 creator A5078182841 @default.
• W2056520707 creator A5080716416 @default.
• W2056520707 creator A5082493185 @default.
• W2056520707 creator A5083649005 @default.
• W2056520707 date "2008-09-05" @default.
• W2056520707 modified "2023-10-10" @default.
• W2056520707 title "Gene-environment Interaction between MBL2 Genotype and Smoking, and the Risk of Gram-positive Bacteraemia" @default.
• W2056520707 cites W1577251139 @default.
• W2056520707 cites W1898928487 @default.
• W2056520707 cites W1981567607 @default.
• W2056520707 cites W1983761351 @default.
• W2056520707 cites W1992830524 @default.
• W2056520707 cites W2020340107 @default.
• W2056520707 cites W2031202761 @default.
• W2056520707 cites W2035488890 @default.
• W2056520707 cites W2040582647 @default.
• W2056520707 cites W2047233465 @default.
• W2056520707 cites W2050606800 @default.
• W2056520707 cites W2065789488 @default.
• W2056520707 cites W2066145052 @default.
• W2056520707 cites W2070618971 @default.
• W2056520707 cites W2084474700 @default.
• W2056520707 cites W2105614022 @default.
• W2056520707 cites W2107907461 @default.
• W2056520707 cites W2119637744 @default.
• W2056520707 cites W2139409203 @default.
• W2056520707 cites W2142360837 @default.
• W2056520707 cites W2143970440 @default.
• W2056520707 cites W2145542662 @default.
• W2056520707 cites W2152799956 @default.
• W2056520707 cites W2164266195 @default.
• W2056520707 cites W2171120557 @default.
• W2056520707 cites W2171219043 @default.
• W2056520707 cites W2171539758 @default.
• W2056520707 cites W2316751401 @default.
• W2056520707 cites W4251364816 @default.
• W2056520707 doi "https://doi.org/10.1111/j.1365-3083.2008.02149.x" @default.
• W2056520707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18782274" @default.
• W2056520707 hasPublicationYear "2008" @default.
• W2056520707 type Work @default.
• W2056520707 sameAs 2056520707 @default.
• W2056520707 citedByCount "10" @default.
• W2056520707 countsByYear W20565207072012 @default.
• W2056520707 countsByYear W20565207072013 @default.
• W2056520707 countsByYear W20565207072014 @default.
• W2056520707 countsByYear W20565207072022 @default.
• W2056520707 crossrefType "journal-article" @default.
• W2056520707 hasAuthorship W2056520707A5024481694 @default.
• W2056520707 hasAuthorship W2056520707A5040554257 @default.
• W2056520707 hasAuthorship W2056520707A5042344507 @default.
• W2056520707 hasAuthorship W2056520707A5047174566 @default.
• W2056520707 hasAuthorship W2056520707A5047519153 @default.
• W2056520707 hasAuthorship W2056520707A5053371659 @default.
• W2056520707 hasAuthorship W2056520707A5078182841 @default.
• W2056520707 hasAuthorship W2056520707A5080716416 @default.
• W2056520707 hasAuthorship W2056520707A5082493185 @default.
• W2056520707 hasAuthorship W2056520707A5083649005 @default.
• W2056520707 hasBestOaLocation W20565207071 @default.
• W2056520707 hasConcept C104317684 @default.
• W2056520707 hasConcept C126322002 @default.
• W2056520707 hasConcept C135763542 @default.
• W2056520707 hasConcept C156957248 @default.
• W2056520707 hasConcept C180754005 @default.
• W2056520707 hasConcept C189413060 @default.
• W2056520707 hasConcept C203014093 @default.
• W2056520707 hasConcept C2779443120 @default.
• W2056520707 hasConcept C2779489039 @default.
• W2056520707 hasConcept C2780758401 @default.
• W2056520707 hasConcept C2781253189 @default.
• W2056520707 hasConcept C501593827 @default.
• W2056520707 hasConcept C50440223 @default.
• W2056520707 hasConcept C523546767 @default.
• W2056520707 hasConcept C54355233 @default.
• W2056520707 hasConcept C71924100 @default.
• W2056520707 hasConcept C86803240 @default.
• W2056520707 hasConcept C89423630 @default.
• W2056520707 hasConcept C90924648 @default.
• W2056520707 hasConceptScore W2056520707C104317684 @default.
• W2056520707 hasConceptScore W2056520707C126322002 @default.
• W2056520707 hasConceptScore W2056520707C135763542 @default.
• W2056520707 hasConceptScore W2056520707C156957248 @default.
• W2056520707 hasConceptScore W2056520707C180754005 @default.
• W2056520707 hasConceptScore W2056520707C189413060 @default.
• W2056520707 hasConceptScore W2056520707C203014093 @default.
• W2056520707 hasConceptScore W2056520707C2779443120 @default.
• W2056520707 hasConceptScore W2056520707C2779489039 @default.
• W2056520707 hasConceptScore W2056520707C2780758401 @default.
• W2056520707 hasConceptScore W2056520707C2781253189 @default.
• W2056520707 hasConceptScore W2056520707C501593827 @default.
• W2056520707 hasConceptScore W2056520707C50440223 @default.

• next