FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056520729> ?p ?o ?g. }

• W2056520729 abstract "Abstract Background Chlamydia trachomatis infection results in reproductive damage in some women. The process and factors involved in this immunopathology are not well understood. This study aimed to investigate the role of primary human cellular responses to chlamydial stress response proteases and chlamydial infection to further identify the immune processes involved in serious disease sequelae. Results Laboratory cell cultures and primary human reproductive epithelial cultures produced IL-6 in response to chlamydial stress response proteases (CtHtrA and CtTsp), UV inactivated Chlamydia, and live Chlamydia . The magnitude of the IL-6 response varied considerably (up to 1000 pg ml -1 ) across different primary human reproductive cultures. Thus different levels of IL-6 production by reproductive epithelia may be a determinant in disease outcome. Interestingly, co-culture models with either THP-1 cells or autologous primary human PBMC generally resulted in increased levels of IL-6, except in the case of live Chlamydia where the level of IL-6 was decreased compared to the epithelial cell culture only, suggesting this pathway may be able to be modulated by live Chlamydia . PBMC responses to the stress response proteases (CtTsp and CtHtrA) did not significantly vary for the different participant cohorts. Therefore, these proteases may possess conserved innate PAMPs. MAP kinases appeared to be involved in this IL-6 induction from human cells. Finally, we also demonstrated that IL-6 was induced by these proteins and Chlamydia from mouse primary reproductive cell cultures (BALB/C mice) and mouse laboratory cell models. Conclusions We have demonstrated that IL-6 may be a key factor for the chlamydial disease outcome in humans, given that primary human reproductive epithelial cell culture showed considerable variation in IL-6 response to Chlamydia or chlamydial proteins, and that the presence of live Chlamydia (but not UV killed) during co-culture resulted in a reduced IL-6 response suggesting this response may be moderated by the presence of the organism." @default.
• W2056520729 created "2016-06-24" @default.
• W2056520729 creator A5008090987 @default.
• W2056520729 creator A5032528228 @default.
• W2056520729 creator A5042380180 @default.
• W2056520729 creator A5045964997 @default.
• W2056520729 creator A5055002773 @default.
• W2056520729 creator A5077570627 @default.
• W2056520729 creator A5079803621 @default.
• W2056520729 date "2013-11-15" @default.
• W2056520729 modified "2023-10-10" @default.
• W2056520729 title "The IL-6 response to Chlamydia from primary reproductive epithelial cells is highly variable and may be involved in differential susceptibility to the immunopathological consequences of chlamydial infection" @default.
• W2056520729 cites W1540296375 @default.
• W2056520729 cites W1967313249 @default.
• W2056520729 cites W1974744480 @default.
• W2056520729 cites W2003642807 @default.
• W2056520729 cites W2014518979 @default.
• W2056520729 cites W2030371658 @default.
• W2056520729 cites W2034935809 @default.
• W2056520729 cites W2039420513 @default.
• W2056520729 cites W2046875135 @default.
• W2056520729 cites W2049666379 @default.
• W2056520729 cites W2057138777 @default.
• W2056520729 cites W2074987160 @default.
• W2056520729 cites W2077611526 @default.
• W2056520729 cites W2078542681 @default.
• W2056520729 cites W2078665434 @default.
• W2056520729 cites W2088914845 @default.
• W2056520729 cites W2094765978 @default.
• W2056520729 cites W2100137707 @default.
• W2056520729 cites W2103336793 @default.
• W2056520729 cites W2105436359 @default.
• W2056520729 cites W2110403818 @default.
• W2056520729 cites W2121711394 @default.
• W2056520729 cites W2125189266 @default.
• W2056520729 cites W2135362750 @default.
• W2056520729 cites W2136214234 @default.
• W2056520729 cites W2141283427 @default.
• W2056520729 cites W2141625507 @default.
• W2056520729 cites W2158858678 @default.
• W2056520729 cites W2162857753 @default.
• W2056520729 cites W2162955479 @default.
• W2056520729 cites W4246361268 @default.
• W2056520729 doi "https://doi.org/10.1186/1471-2172-14-50" @default.
• W2056520729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4225670" @default.
• W2056520729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24238294" @default.
• W2056520729 hasPublicationYear "2013" @default.
• W2056520729 type Work @default.
• W2056520729 sameAs 2056520729 @default.
• W2056520729 citedByCount "22" @default.
• W2056520729 countsByYear W20565207292014 @default.
• W2056520729 countsByYear W20565207292015 @default.
• W2056520729 countsByYear W20565207292016 @default.
• W2056520729 countsByYear W20565207292017 @default.
• W2056520729 countsByYear W20565207292018 @default.
• W2056520729 countsByYear W20565207292019 @default.
• W2056520729 countsByYear W20565207292020 @default.
• W2056520729 countsByYear W20565207292021 @default.
• W2056520729 countsByYear W20565207292022 @default.
• W2056520729 countsByYear W20565207292023 @default.
• W2056520729 crossrefType "journal-article" @default.
• W2056520729 hasAuthorship W2056520729A5008090987 @default.
• W2056520729 hasAuthorship W2056520729A5032528228 @default.
• W2056520729 hasAuthorship W2056520729A5042380180 @default.
• W2056520729 hasAuthorship W2056520729A5045964997 @default.
• W2056520729 hasAuthorship W2056520729A5055002773 @default.
• W2056520729 hasAuthorship W2056520729A5077570627 @default.
• W2056520729 hasAuthorship W2056520729A5079803621 @default.
• W2056520729 hasBestOaLocation W20565207291 @default.
• W2056520729 hasConcept C136449434 @default.
• W2056520729 hasConcept C181199279 @default.
• W2056520729 hasConcept C182220744 @default.
• W2056520729 hasConcept C203014093 @default.
• W2056520729 hasConcept C2777391075 @default.
• W2056520729 hasConcept C2779204014 @default.
• W2056520729 hasConcept C2780122209 @default.
• W2056520729 hasConcept C55493867 @default.
• W2056520729 hasConcept C86803240 @default.
• W2056520729 hasConcept C8891405 @default.
• W2056520729 hasConceptScore W2056520729C136449434 @default.
• W2056520729 hasConceptScore W2056520729C181199279 @default.
• W2056520729 hasConceptScore W2056520729C182220744 @default.
• W2056520729 hasConceptScore W2056520729C203014093 @default.
• W2056520729 hasConceptScore W2056520729C2777391075 @default.
• W2056520729 hasConceptScore W2056520729C2779204014 @default.
• W2056520729 hasConceptScore W2056520729C2780122209 @default.
• W2056520729 hasConceptScore W2056520729C55493867 @default.
• W2056520729 hasConceptScore W2056520729C86803240 @default.
• W2056520729 hasConceptScore W2056520729C8891405 @default.
• W2056520729 hasIssue "1" @default.
• W2056520729 hasLocation W20565207291 @default.
• W2056520729 hasLocation W20565207292 @default.
• W2056520729 hasLocation W20565207293 @default.
• W2056520729 hasLocation W20565207294 @default.
• W2056520729 hasLocation W20565207295 @default.
• W2056520729 hasLocation W20565207296 @default.
• W2056520729 hasOpenAccess W2056520729 @default.
• W2056520729 hasPrimaryLocation W20565207291 @default.
• W2056520729 hasRelatedWork W1830526186 @default.
• W2056520729 hasRelatedWork W188756146 @default.

• next