Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056521686> ?p ?o ?g. }
- W2056521686 endingPage "1961" @default.
- W2056521686 startingPage "1953" @default.
- W2056521686 abstract "The bcl-6 proto-oncogene encodes a POZ/zinc finger transcriptional repressor expressed in germinal center (GC) B and T cells and required for GC formation and antibody affinity maturation. Deregulation of bcl-6 expression by chromosomal rearrangements and point mutations of the bcl-6 promoter region are implicated in the pathogenesis of B-cell lymphoma. The signals regulating bcl-6 expression are not known. Here we show that antigen receptor activation leads to BCL-6 phosphorylation by mitogen-activated protein kinase (MAPK). Phosphorylation, in turn, targets BCL-6 for rapid degradation by the ubiquitin/proteasome pathway. These findings indicate that BCL-6 expression is directly controlled by the antigen receptor via MAPK activation. This signaling pathway may be crucial for the control of B-cell differentiation and antibody response and has implications for the regulation of other POZ/zinc finger transcription factors in other tissues." @default.
- W2056521686 created "2016-06-24" @default.
- W2056521686 creator A5006765090 @default.
- W2056521686 creator A5012955086 @default.
- W2056521686 creator A5025137963 @default.
- W2056521686 date "1998-07-01" @default.
- W2056521686 modified "2023-10-08" @default.
- W2056521686 title "Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor" @default.
- W2056521686 cites W147956781 @default.
- W2056521686 cites W1488731933 @default.
- W2056521686 cites W1502839280 @default.
- W2056521686 cites W1519809500 @default.
- W2056521686 cites W1551864973 @default.
- W2056521686 cites W1587018460 @default.
- W2056521686 cites W1589862665 @default.
- W2056521686 cites W1601529283 @default.
- W2056521686 cites W1863409422 @default.
- W2056521686 cites W188006079 @default.
- W2056521686 cites W1964689081 @default.
- W2056521686 cites W1971915141 @default.
- W2056521686 cites W1982357474 @default.
- W2056521686 cites W1988917700 @default.
- W2056521686 cites W1991311051 @default.
- W2056521686 cites W1995204178 @default.
- W2056521686 cites W1996212879 @default.
- W2056521686 cites W2003209070 @default.
- W2056521686 cites W2008744347 @default.
- W2056521686 cites W2010117150 @default.
- W2056521686 cites W2010601153 @default.
- W2056521686 cites W2013036001 @default.
- W2056521686 cites W2034119794 @default.
- W2056521686 cites W2048143383 @default.
- W2056521686 cites W2050164732 @default.
- W2056521686 cites W2053632669 @default.
- W2056521686 cites W2075079030 @default.
- W2056521686 cites W2075855869 @default.
- W2056521686 cites W2082776443 @default.
- W2056521686 cites W2084999188 @default.
- W2056521686 cites W2086893957 @default.
- W2056521686 cites W2089559354 @default.
- W2056521686 cites W2089880838 @default.
- W2056521686 cites W2091403769 @default.
- W2056521686 cites W2100534395 @default.
- W2056521686 cites W2101143531 @default.
- W2056521686 cites W2101759139 @default.
- W2056521686 cites W2103116478 @default.
- W2056521686 cites W2105840691 @default.
- W2056521686 cites W2121781216 @default.
- W2056521686 cites W2136838504 @default.
- W2056521686 cites W2144660263 @default.
- W2056521686 cites W2150235363 @default.
- W2056521686 cites W216208948 @default.
- W2056521686 cites W2171483790 @default.
- W2056521686 cites W2248056767 @default.
- W2056521686 cites W2261002131 @default.
- W2056521686 cites W2267601995 @default.
- W2056521686 cites W2339515175 @default.
- W2056521686 cites W2413391573 @default.
- W2056521686 cites W2414472129 @default.
- W2056521686 cites W26566176 @default.
- W2056521686 cites W285723765 @default.
- W2056521686 cites W4230370384 @default.
- W2056521686 cites W4235967964 @default.
- W2056521686 cites W4249612042 @default.
- W2056521686 cites W4251633039 @default.
- W2056521686 cites W4375835144 @default.
- W2056521686 cites W88626313 @default.
- W2056521686 doi "https://doi.org/10.1101/gad.12.13.1953" @default.
- W2056521686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316953" @default.
- W2056521686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9649500" @default.
- W2056521686 hasPublicationYear "1998" @default.
- W2056521686 type Work @default.
- W2056521686 sameAs 2056521686 @default.
- W2056521686 citedByCount "270" @default.
- W2056521686 countsByYear W20565216862012 @default.
- W2056521686 countsByYear W20565216862013 @default.
- W2056521686 countsByYear W20565216862014 @default.
- W2056521686 countsByYear W20565216862015 @default.
- W2056521686 countsByYear W20565216862016 @default.
- W2056521686 countsByYear W20565216862017 @default.
- W2056521686 countsByYear W20565216862018 @default.
- W2056521686 countsByYear W20565216862019 @default.
- W2056521686 countsByYear W20565216862020 @default.
- W2056521686 countsByYear W20565216862021 @default.
- W2056521686 countsByYear W20565216862022 @default.
- W2056521686 countsByYear W20565216862023 @default.
- W2056521686 crossrefType "journal-article" @default.
- W2056521686 hasAuthorship W2056521686A5006765090 @default.
- W2056521686 hasAuthorship W2056521686A5012955086 @default.
- W2056521686 hasAuthorship W2056521686A5025137963 @default.
- W2056521686 hasBestOaLocation W20565216861 @default.
- W2056521686 hasConcept C104317684 @default.
- W2056521686 hasConcept C11960822 @default.
- W2056521686 hasConcept C153911025 @default.
- W2056521686 hasConcept C184235292 @default.
- W2056521686 hasConcept C24284526 @default.
- W2056521686 hasConcept C502942594 @default.
- W2056521686 hasConcept C55493867 @default.