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- W2056522794 abstract "Introduction: We present a retrospective analysis of 145 patients with hemifacial spasm (HFS) treated with botulinum toxin type A (BTX; Botox® or Dysport®) in our movement disorder clinic between 1993 and 2007. Methods: BTX dose per treatment and per treated muscle, global clinical improvement (GCI; 0–3; 0=no effect, 3=marked improvement), side effects, latency and duration of response were recalled from our database. Statistical analysis was carried out using SPSS v 14.0 (SPSS, Chicago, IL). Results: The mean dosage of BTX was 22±10 units (ranged from 5 to 50 units) for Botox® and 51±24 units (ranged from 15 to 100 U) for Dysport®. Treatment duration ranged from 2 to 11 years with a mean value of 6 years. The mean latency of response was 6.1±3.2 days for Botox® and 5.9±3.4 for Dysport®. The mean duration of response was similar for both products: 12.1±3.1 weeks for Botox® and 12.2±3.7 weeks for Dysport®. The good treatment effect was reflected by GCI values above 2.5. The mean GCI for Botox® was 2.6±0.3 and 2.6±0.4 for Dysport®. None of the patients was a primary or secondary non-responder. Discussion: Our data confirm the long-term safety and effectiveness of BTX treatment in HFS." @default.
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- W2056522794 date "2008-06-01" @default.
- W2056522794 modified "2023-10-04" @default.
- W2056522794 title "Long-term treatment with botulinum toxin type A in hemifacial spasm" @default.
- W2056522794 doi "https://doi.org/10.1016/j.toxicon.2008.04.093" @default.
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