Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056523276> ?p ?o ?g. }
- W2056523276 endingPage "714" @default.
- W2056523276 startingPage "703" @default.
- W2056523276 abstract "Nigericin was among the first polyether ionophores to be discovered, but its biosynthesis remains obscure. The biosynthetic gene cluster for nigericin has been serendipitously cloned from Streptomyces sp. DSM4137, and deletion of this gene cluster abolished the production of both nigericin and the closely related metabolite abierixin. Detailed comparison of the nigericin biosynthetic genes with their counterparts in the biosynthetic clusters for other polyketides has prompted a significant revision of the proposed common pathway for polyether biosynthesis. In particular, we present evidence that in nigericin, nanchangmycin, and monensin, an unusual ketosynthase-like protein, KSX, transfers the initially formed linear polyketide chain to a discrete acyl carrier protein, ACPX, for oxidative cyclization. Consistent with this, deletion of either monACPX or monKSX from the monensin gene cluster effectively abolished monensin A biosynthesis." @default.
- W2056523276 created "2016-06-24" @default.
- W2056523276 creator A5001887570 @default.
- W2056523276 creator A5009329566 @default.
- W2056523276 creator A5009410142 @default.
- W2056523276 creator A5045961417 @default.
- W2056523276 creator A5050139203 @default.
- W2056523276 creator A5050419694 @default.
- W2056523276 creator A5067406705 @default.
- W2056523276 creator A5072321492 @default.
- W2056523276 date "2007-06-01" @default.
- W2056523276 modified "2023-10-10" @default.
- W2056523276 title "Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137" @default.
- W2056523276 cites W1483889297 @default.
- W2056523276 cites W1486568163 @default.
- W2056523276 cites W1580639168 @default.
- W2056523276 cites W1851956441 @default.
- W2056523276 cites W193542914 @default.
- W2056523276 cites W1935563522 @default.
- W2056523276 cites W1964862470 @default.
- W2056523276 cites W1969007008 @default.
- W2056523276 cites W1974909599 @default.
- W2056523276 cites W1975167671 @default.
- W2056523276 cites W1987358726 @default.
- W2056523276 cites W1988752536 @default.
- W2056523276 cites W1995352629 @default.
- W2056523276 cites W2003589293 @default.
- W2056523276 cites W2014519534 @default.
- W2056523276 cites W2014734955 @default.
- W2056523276 cites W2025168003 @default.
- W2056523276 cites W2025889664 @default.
- W2056523276 cites W2028622989 @default.
- W2056523276 cites W2030100059 @default.
- W2056523276 cites W2030203546 @default.
- W2056523276 cites W2036360388 @default.
- W2056523276 cites W2038230234 @default.
- W2056523276 cites W2041786580 @default.
- W2056523276 cites W2047373648 @default.
- W2056523276 cites W2058382321 @default.
- W2056523276 cites W2067058097 @default.
- W2056523276 cites W2069059667 @default.
- W2056523276 cites W2069121234 @default.
- W2056523276 cites W2073497058 @default.
- W2056523276 cites W2077794250 @default.
- W2056523276 cites W2082430739 @default.
- W2056523276 cites W2088084221 @default.
- W2056523276 cites W2092792905 @default.
- W2056523276 cites W2115775104 @default.
- W2056523276 cites W2116137883 @default.
- W2056523276 cites W2119888995 @default.
- W2056523276 cites W2123781174 @default.
- W2056523276 cites W2127734104 @default.
- W2056523276 cites W2135255584 @default.
- W2056523276 cites W2137625703 @default.
- W2056523276 cites W2148927739 @default.
- W2056523276 cites W2149783432 @default.
- W2056523276 cites W2158714788 @default.
- W2056523276 cites W2171555414 @default.
- W2056523276 cites W2325639093 @default.
- W2056523276 cites W2606974086 @default.
- W2056523276 cites W3005221263 @default.
- W2056523276 doi "https://doi.org/10.1016/j.chembiol.2007.05.011" @default.
- W2056523276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17584617" @default.
- W2056523276 hasPublicationYear "2007" @default.
- W2056523276 type Work @default.
- W2056523276 sameAs 2056523276 @default.
- W2056523276 citedByCount "106" @default.
- W2056523276 countsByYear W20565232762012 @default.
- W2056523276 countsByYear W20565232762013 @default.
- W2056523276 countsByYear W20565232762014 @default.
- W2056523276 countsByYear W20565232762015 @default.
- W2056523276 countsByYear W20565232762016 @default.
- W2056523276 countsByYear W20565232762017 @default.
- W2056523276 countsByYear W20565232762018 @default.
- W2056523276 countsByYear W20565232762019 @default.
- W2056523276 countsByYear W20565232762020 @default.
- W2056523276 countsByYear W20565232762021 @default.
- W2056523276 countsByYear W20565232762022 @default.
- W2056523276 countsByYear W20565232762023 @default.
- W2056523276 crossrefType "journal-article" @default.
- W2056523276 hasAuthorship W2056523276A5001887570 @default.
- W2056523276 hasAuthorship W2056523276A5009329566 @default.
- W2056523276 hasAuthorship W2056523276A5009410142 @default.
- W2056523276 hasAuthorship W2056523276A5045961417 @default.
- W2056523276 hasAuthorship W2056523276A5050139203 @default.
- W2056523276 hasAuthorship W2056523276A5050419694 @default.
- W2056523276 hasAuthorship W2056523276A5067406705 @default.
- W2056523276 hasAuthorship W2056523276A5072321492 @default.
- W2056523276 hasConcept C104317684 @default.
- W2056523276 hasConcept C2777330628 @default.
- W2056523276 hasConcept C2777477808 @default.
- W2056523276 hasConcept C2777763344 @default.
- W2056523276 hasConcept C2778635478 @default.
- W2056523276 hasConcept C2779920670 @default.
- W2056523276 hasConcept C2780224938 @default.
- W2056523276 hasConcept C36857842 @default.
- W2056523276 hasConcept C41625074 @default.
- W2056523276 hasConcept C523546767 @default.