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• W2056524260 startingPage "e1002134" @default.
• W2056524260 abstract "Although a highly heritable and disabling disease, bipolar disorder's (BD) genetic variants have been challenging to identify. We present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5×10−7). To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. Within BD, SNPs near exons exhibit a greater probability of replication, supporting an enrichment of reproducible associations near functional regions of genes. These results indicate that there is likely common genetic variation associated with BD near exons (±10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies." @default.
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• W2056524260 date "2011-06-30" @default.
• W2056524260 modified "2023-09-28" @default.
• W2056524260 title "Genome-Wide Association of Bipolar Disorder Suggests an Enrichment of Replicable Associations in Regions near Genes" @default.
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• W2056524260 doi "https://doi.org/10.1371/journal.pgen.1002134" @default.
• W2056524260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3128104" @default.
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