FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056524306> ?p ?o ?g. }

• W2056524306 endingPage "2218" @default.
• W2056524306 startingPage "2213" @default.
• W2056524306 abstract "A novel computer model of the HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI) binding pocket, which was generated using high resolution crystal structure information from 9 individual RT/NNI complexes, revealed previously unrecognized ligand derivatization sites for phenethylthiazolylthiourea (PETT) derivatives. Spatial gaps surrounding the pyridyl ring of the active PETT derivative trovirdine were discovered during modeling procedures. Docking studies using the computer-generated model of the binding pocket (composite binding pocket) suggested that the replacement of the planar pyridyl ring of trovirdine with a nonplanar piperidinyl or piperazinyl ring, which occupy larger volumes, would better fill the spacious Wing 2 region of the butterfly-shaped NNI binding pocket. The anti-HIV activity of the synthesized heterocyclic compounds N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea was examined in HTLVIIIB-infected peripheral blood mononuclear cells. Both compounds were more potent than trovirdine and abrogated HIV replication at nanomolar concentrations without any evidence of cytotoxicity." @default.
• W2056524306 created "2016-06-24" @default.
• W2056524306 creator A5016366257 @default.
• W2056524306 creator A5042950703 @default.
• W2056524306 creator A5048956276 @default.
• W2056524306 creator A5062208175 @default.
• W2056524306 creator A5091381226 @default.
• W2056524306 date "1998-08-01" @default.
• W2056524306 modified "2023-10-05" @default.
• W2056524306 title "Structure-based design of N-[2-(1-piperidinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N′-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase" @default.
• W2056524306 cites W1576999979 @default.
• W2056524306 cites W1984814223 @default.
• W2056524306 cites W1989357838 @default.
• W2056524306 cites W2006477370 @default.
• W2056524306 cites W2008954911 @default.
• W2056524306 cites W2010944339 @default.
• W2056524306 cites W2027148086 @default.
• W2056524306 cites W2049935537 @default.
• W2056524306 cites W2053595346 @default.
• W2056524306 cites W2061482690 @default.
• W2056524306 cites W2063381239 @default.
• W2056524306 cites W2067786897 @default.
• W2056524306 cites W2069399912 @default.
• W2056524306 cites W2069815958 @default.
• W2056524306 cites W2072409481 @default.
• W2056524306 cites W2101963388 @default.
• W2056524306 cites W2102098015 @default.
• W2056524306 cites W2103766655 @default.
• W2056524306 cites W2110662513 @default.
• W2056524306 cites W2135360688 @default.
• W2056524306 cites W2146411900 @default.
• W2056524306 cites W2220354139 @default.
• W2056524306 cites W2333133071 @default.
• W2056524306 cites W2950606277 @default.
• W2056524306 cites W3023206542 @default.
• W2056524306 doi "https://doi.org/10.1016/s0960-894x(98)00384-9" @default.
• W2056524306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9873515" @default.
• W2056524306 hasPublicationYear "1998" @default.
• W2056524306 type Work @default.
• W2056524306 sameAs 2056524306 @default.
• W2056524306 citedByCount "50" @default.
• W2056524306 countsByYear W20565243062015 @default.
• W2056524306 countsByYear W20565243062017 @default.
• W2056524306 countsByYear W20565243062018 @default.
• W2056524306 countsByYear W20565243062019 @default.
• W2056524306 crossrefType "journal-article" @default.
• W2056524306 hasAuthorship W2056524306A5016366257 @default.
• W2056524306 hasAuthorship W2056524306A5042950703 @default.
• W2056524306 hasAuthorship W2056524306A5048956276 @default.
• W2056524306 hasAuthorship W2056524306A5062208175 @default.
• W2056524306 hasAuthorship W2056524306A5091381226 @default.
• W2056524306 hasConcept C109316439 @default.
• W2056524306 hasConcept C114373084 @default.
• W2056524306 hasConcept C159110408 @default.
• W2056524306 hasConcept C162356407 @default.
• W2056524306 hasConcept C178790620 @default.
• W2056524306 hasConcept C178910836 @default.
• W2056524306 hasConcept C185592680 @default.
• W2056524306 hasConcept C202751555 @default.
• W2056524306 hasConcept C2776543447 @default.
• W2056524306 hasConcept C2776923573 @default.
• W2056524306 hasConcept C2780378348 @default.
• W2056524306 hasConcept C2780538656 @default.
• W2056524306 hasConcept C41685203 @default.
• W2056524306 hasConcept C43617362 @default.
• W2056524306 hasConcept C55493867 @default.
• W2056524306 hasConcept C71240020 @default.
• W2056524306 hasConcept C71924100 @default.
• W2056524306 hasConceptScore W2056524306C109316439 @default.
• W2056524306 hasConceptScore W2056524306C114373084 @default.
• W2056524306 hasConceptScore W2056524306C159110408 @default.
• W2056524306 hasConceptScore W2056524306C162356407 @default.
• W2056524306 hasConceptScore W2056524306C178790620 @default.
• W2056524306 hasConceptScore W2056524306C178910836 @default.
• W2056524306 hasConceptScore W2056524306C185592680 @default.
• W2056524306 hasConceptScore W2056524306C202751555 @default.
• W2056524306 hasConceptScore W2056524306C2776543447 @default.
• W2056524306 hasConceptScore W2056524306C2776923573 @default.
• W2056524306 hasConceptScore W2056524306C2780378348 @default.
• W2056524306 hasConceptScore W2056524306C2780538656 @default.
• W2056524306 hasConceptScore W2056524306C41685203 @default.
• W2056524306 hasConceptScore W2056524306C43617362 @default.
• W2056524306 hasConceptScore W2056524306C55493867 @default.
• W2056524306 hasConceptScore W2056524306C71240020 @default.
• W2056524306 hasConceptScore W2056524306C71924100 @default.
• W2056524306 hasIssue "16" @default.
• W2056524306 hasLocation W20565243061 @default.
• W2056524306 hasLocation W20565243062 @default.
• W2056524306 hasOpenAccess W2056524306 @default.
• W2056524306 hasPrimaryLocation W20565243061 @default.
• W2056524306 hasRelatedWork W1641625687 @default.
• W2056524306 hasRelatedWork W1910526769 @default.
• W2056524306 hasRelatedWork W2010735377 @default.
• W2056524306 hasRelatedWork W2018927745 @default.
• W2056524306 hasRelatedWork W2031449811 @default.
• W2056524306 hasRelatedWork W2068224494 @default.
• W2056524306 hasRelatedWork W2081652870 @default.
• W2056524306 hasRelatedWork W2264709198 @default.

• next