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- W2056524723 abstract "The amino‐terminal region of the human sex steroid‐binding protein of plasma (SBP or SHBG) containing K134 and M139 was found to represent part of the steroid‐binding site. This was accomplished by constructing and expressing site‐directed mutants having the following replacements: M139L, M139K, M139S, K134A, H235S, and Y57F. The results indicated that M139L and H235S were fully‐active, K134A and Y57F were 50 and 67% active, M139K was 7% active, and M 139S was inactive. These results support affinity‐labeling data indicating that both K134 and M139 are located in or near the site, and suggest that Y57 may play a role in steroid binding. The fully active H235S mutant reveals that H235 is not involved in the steroid‐binding process." @default.
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- W2056524723 date "1992-09-28" @default.
- W2056524723 modified "2023-10-11" @default.
- W2056524723 title "Localization of the steroid‐binding site of the human sex steroid‐binding protein of plasma (SBP or SHBG) by site‐directed mutagenesis" @default.
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- W2056524723 doi "https://doi.org/10.1016/0014-5793(92)81309-a" @default.
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