FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056524740> ?p ?o ?g. }

• W2056524740 endingPage "1848" @default.
• W2056524740 startingPage "1841" @default.
• W2056524740 abstract "The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs. The goal is to reduce the reservoir of microfilariae in the blood to a level that is insufficient to maintain transmission by the mosquito vector.In nearly 2500 residents of Papua New Guinea, we prospectively assessed the effects of four annual treatments with a single dose of diethylcarbamazine plus ivermectin or diethylcarbamazine alone on the incidence of microfilariae-positive infections, the severity of lymphatic disease, and the rate of transmission of Wuchereria bancrofti by mosquitoes. Random assignment to treatment regimens was carried out according to the village of residence, and villages were categorized as having moderate or high rates of transmission.The four annual treatments with either drug regimen were taken by 77 to 86 percent of the members of the population who were at least five years old; treatments were well tolerated. The proportion with microfilariae-positive infections decreased by 86 to 98 percent, with a greater reduction in areas with a moderate rate of transmission than in those with a high rate. The respective aggregate frequencies of hydrocele and leg lymphedema were 15 percent and 5 percent before the trial began, and 5 percent (P<0.001) and 4 percent (P=0.04) after five years. Hydrocele and leg lymphedema were eliminated in 87 percent and 69 percent, respectively, of those who had these conditions at the outset. The rate of transmission by mosquitoes decreased substantially, and new microfilariae-positive infections in children were almost completely prevented over the five-year study period.Annual mass treatment with drugs such as diethylcarbamazine can virtually eliminate the reservoir of microfilariae and greatly reduce the frequency of clinical lymphatic abnormalities due to bancroftian filariasis. Eradication may be possible in areas with moderate rates of transmission, but longer periods of treatment or additional control measures may be necessary in areas with high rates of transmission." @default.
• W2056524740 created "2016-06-24" @default.
• W2056524740 creator A5026874355 @default.
• W2056524740 creator A5028607173 @default.
• W2056524740 creator A5040921378 @default.
• W2056524740 creator A5049592593 @default.
• W2056524740 creator A5064038413 @default.
• W2056524740 creator A5065056171 @default.
• W2056524740 creator A5068290243 @default.
• W2056524740 creator A5085461249 @default.
• W2056524740 creator A5090702293 @default.
• W2056524740 date "2002-12-05" @default.
• W2056524740 modified "2023-10-12" @default.
• W2056524740 title "Mass Treatment to Eliminate Filariasis in Papua New Guinea" @default.
• W2056524740 cites W1968756704 @default.
• W2056524740 cites W1970157102 @default.
• W2056524740 cites W1986847888 @default.
• W2056524740 cites W1987415888 @default.
• W2056524740 cites W1989064596 @default.
• W2056524740 cites W1991279333 @default.
• W2056524740 cites W1995372747 @default.
• W2056524740 cites W2003861955 @default.
• W2056524740 cites W2014435050 @default.
• W2056524740 cites W2023871567 @default.
• W2056524740 cites W2030399005 @default.
• W2056524740 cites W2040311123 @default.
• W2056524740 cites W2044514129 @default.
• W2056524740 cites W2054163484 @default.
• W2056524740 cites W2056075233 @default.
• W2056524740 cites W2076503115 @default.
• W2056524740 cites W2088252446 @default.
• W2056524740 cites W2100013623 @default.
• W2056524740 cites W2109691397 @default.
• W2056524740 cites W2110486035 @default.
• W2056524740 cites W2116126841 @default.
• W2056524740 cites W2118116578 @default.
• W2056524740 cites W2149860264 @default.
• W2056524740 cites W2149883352 @default.
• W2056524740 cites W2151970980 @default.
• W2056524740 cites W2155297677 @default.
• W2056524740 cites W2162635154 @default.
• W2056524740 cites W2163342804 @default.
• W2056524740 cites W2170196498 @default.
• W2056524740 cites W2403602325 @default.
• W2056524740 cites W2418566251 @default.
• W2056524740 cites W34681063 @default.
• W2056524740 cites W4299988070 @default.
• W2056524740 cites W2025198756 @default.
• W2056524740 doi "https://doi.org/10.1056/nejmoa021309" @default.
• W2056524740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466508" @default.
• W2056524740 hasPublicationYear "2002" @default.
• W2056524740 type Work @default.
• W2056524740 sameAs 2056524740 @default.
• W2056524740 citedByCount "141" @default.
• W2056524740 countsByYear W20565247402012 @default.
• W2056524740 countsByYear W20565247402013 @default.
• W2056524740 countsByYear W20565247402014 @default.
• W2056524740 countsByYear W20565247402015 @default.
• W2056524740 countsByYear W20565247402016 @default.
• W2056524740 countsByYear W20565247402017 @default.
• W2056524740 countsByYear W20565247402018 @default.
• W2056524740 countsByYear W20565247402019 @default.
• W2056524740 countsByYear W20565247402021 @default.
• W2056524740 countsByYear W20565247402022 @default.
• W2056524740 crossrefType "journal-article" @default.
• W2056524740 hasAuthorship W2056524740A5026874355 @default.
• W2056524740 hasAuthorship W2056524740A5028607173 @default.
• W2056524740 hasAuthorship W2056524740A5040921378 @default.
• W2056524740 hasAuthorship W2056524740A5049592593 @default.
• W2056524740 hasAuthorship W2056524740A5064038413 @default.
• W2056524740 hasAuthorship W2056524740A5065056171 @default.
• W2056524740 hasAuthorship W2056524740A5068290243 @default.
• W2056524740 hasAuthorship W2056524740A5085461249 @default.
• W2056524740 hasAuthorship W2056524740A5090702293 @default.
• W2056524740 hasBestOaLocation W20565247401 @default.
• W2056524740 hasConcept C119599485 @default.
• W2056524740 hasConcept C120665830 @default.
• W2056524740 hasConcept C121332964 @default.
• W2056524740 hasConcept C126322002 @default.
• W2056524740 hasConcept C127413603 @default.
• W2056524740 hasConcept C141071460 @default.
• W2056524740 hasConcept C165901193 @default.
• W2056524740 hasConcept C181152851 @default.
• W2056524740 hasConcept C203014093 @default.
• W2056524740 hasConcept C2776158911 @default.
• W2056524740 hasConcept C2777143589 @default.
• W2056524740 hasConcept C2777411658 @default.
• W2056524740 hasConcept C2777499811 @default.
• W2056524740 hasConcept C2777629521 @default.
• W2056524740 hasConcept C2778141896 @default.
• W2056524740 hasConcept C2778672586 @default.
• W2056524740 hasConcept C2779359454 @default.
• W2056524740 hasConcept C2780133432 @default.
• W2056524740 hasConcept C2781413609 @default.
• W2056524740 hasConcept C2908647359 @default.
• W2056524740 hasConcept C42972112 @default.
• W2056524740 hasConcept C61511704 @default.
• W2056524740 hasConcept C71924100 @default.

• next