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- W2056525067 abstract "Experimental induction of pulmonary emphysema caused an increase in sensitivity of the rat to toxicity from inhalation of propellants. The emphysematous rat showed an exaggerated reduction in pulmonary compliance in response to inhalation of trichlorofluoromethane (FC 11). In emphysematous and nonemphysematous rats without anesthesia the inhalation of FC 11 caused tachycardia, arrhythmias and other abnormalities in the electrocardiogram. The tachycardiac response was eliminated by induction of barbiturate anesthesia, which increased the sensitivity of the heart to occurrence of abnormalities in the electrocardiogram in response to inhalation of FC 11 as well as of dichlorodifluoromethane (FC 12) and difluoroethane (FC 152a). The acceleration in heart rate in response to inhalation of FC 11, hypoxia or hypercapnea was prevented by prior treatment with a beta-blocking drug." @default.
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- W2056525067 date "1975-02-01" @default.
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- W2056525067 title "Toxicity of aerosol propellants in the respiratory and circulatory systems VII. Influence of pulmonary emphysema and anesthesia in the rat" @default.
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- W2056525067 doi "https://doi.org/10.1016/0300-483x(75)90087-6" @default.
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