FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056527928> ?p ?o ?g. }

• W2056527928 endingPage "642" @default.
• W2056527928 startingPage "636" @default.
• W2056527928 abstract "Taxol is used in chemotherapy regimens against breast and ovarian cancer. Treatment of tumor model cell lines with taxol induces apoptosis, but exact mechanism is not sufficiently understood. Our results demonstrate that in response to taxol, various cell types differentially utilize distinct apoptotic pathways. Using MCF7 breast carcinoma cells transfected with caspase-3 gene, we showed that taxol-induced apoptosis occurred in the absence of caspase-3 and caspase-9 activation. Similar results were obtained with ovarian SKOV3 carcinoma cells, expressing high level of endogenous caspase-3. In contrast, staurosporine-induced apoptosis in these cells was accompanied by proteolytic cleavage of pro-caspase-3 and induction of caspase-3 enzymatic activity. The effect of taxol appears to be cell type-specific, since taxol-induced apoptosis in leukemia U937 cells involved caspase-3 activation step. We conclude that a unique caspase-3 and caspase-9 independent pathway is elicited by taxol to induce apoptosis in human ovarian and breast cancinoma cells." @default.
• W2056527928 created "2016-06-24" @default.
• W2056527928 creator A5004819362 @default.
• W2056527928 creator A5021088714 @default.
• W2056527928 creator A5036952733 @default.
• W2056527928 creator A5041194337 @default.
• W2056527928 creator A5050161759 @default.
• W2056527928 creator A5057941116 @default.
• W2056527928 creator A5086272559 @default.
• W2056527928 date "2002-05-24" @default.
• W2056527928 modified "2023-10-09" @default.
• W2056527928 title "Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent" @default.
• W2056527928 cites W1605123818 @default.
• W2056527928 cites W1812279404 @default.
• W2056527928 cites W1979487870 @default.
• W2056527928 cites W1991707369 @default.
• W2056527928 cites W1992546538 @default.
• W2056527928 cites W2001099356 @default.
• W2056527928 cites W2004877384 @default.
• W2056527928 cites W2013510760 @default.
• W2056527928 cites W2024437197 @default.
• W2056527928 cites W2025696853 @default.
• W2056527928 cites W2037490361 @default.
• W2056527928 cites W2049096342 @default.
• W2056527928 cites W2061497413 @default.
• W2056527928 cites W2063017603 @default.
• W2056527928 cites W2067299834 @default.
• W2056527928 cites W2085601531 @default.
• W2056527928 cites W2087450028 @default.
• W2056527928 cites W2116217484 @default.
• W2056527928 cites W2120473562 @default.
• W2056527928 cites W2123671636 @default.
• W2056527928 cites W2154554320 @default.
• W2056527928 cites W2318070376 @default.
• W2056527928 cites W2326516413 @default.
• W2056527928 cites W2338127681 @default.
• W2056527928 cites W2400588389 @default.
• W2056527928 cites W4255762755 @default.
• W2056527928 doi "https://doi.org/10.1038/sj.cdd.4401012" @default.
• W2056527928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12032672" @default.
• W2056527928 hasPublicationYear "2002" @default.
• W2056527928 type Work @default.
• W2056527928 sameAs 2056527928 @default.
• W2056527928 citedByCount "120" @default.
• W2056527928 countsByYear W20565279282012 @default.
• W2056527928 countsByYear W20565279282013 @default.
• W2056527928 countsByYear W20565279282014 @default.
• W2056527928 countsByYear W20565279282015 @default.
• W2056527928 countsByYear W20565279282016 @default.
• W2056527928 countsByYear W20565279282017 @default.
• W2056527928 countsByYear W20565279282018 @default.
• W2056527928 countsByYear W20565279282019 @default.
• W2056527928 countsByYear W20565279282020 @default.
• W2056527928 countsByYear W20565279282021 @default.
• W2056527928 countsByYear W20565279282022 @default.
• W2056527928 countsByYear W20565279282023 @default.
• W2056527928 crossrefType "journal-article" @default.
• W2056527928 hasAuthorship W2056527928A5004819362 @default.
• W2056527928 hasAuthorship W2056527928A5021088714 @default.
• W2056527928 hasAuthorship W2056527928A5036952733 @default.
• W2056527928 hasAuthorship W2056527928A5041194337 @default.
• W2056527928 hasAuthorship W2056527928A5050161759 @default.
• W2056527928 hasAuthorship W2056527928A5057941116 @default.
• W2056527928 hasAuthorship W2056527928A5086272559 @default.
• W2056527928 hasBestOaLocation W20565279281 @default.
• W2056527928 hasConcept C121608353 @default.
• W2056527928 hasConcept C12519072 @default.
• W2056527928 hasConcept C185592680 @default.
• W2056527928 hasConcept C190283241 @default.
• W2056527928 hasConcept C195794163 @default.
• W2056527928 hasConcept C2779084600 @default.
• W2056527928 hasConcept C2780427987 @default.
• W2056527928 hasConcept C3018521938 @default.
• W2056527928 hasConcept C3019054536 @default.
• W2056527928 hasConcept C31573885 @default.
• W2056527928 hasConcept C48297814 @default.
• W2056527928 hasConcept C502942594 @default.
• W2056527928 hasConcept C530470458 @default.
• W2056527928 hasConcept C54009773 @default.
• W2056527928 hasConcept C54355233 @default.
• W2056527928 hasConcept C55493867 @default.
• W2056527928 hasConcept C62478195 @default.
• W2056527928 hasConcept C81885089 @default.
• W2056527928 hasConcept C86803240 @default.
• W2056527928 hasConcept C95444343 @default.
• W2056527928 hasConcept C98424977 @default.
• W2056527928 hasConceptScore W2056527928C121608353 @default.
• W2056527928 hasConceptScore W2056527928C12519072 @default.
• W2056527928 hasConceptScore W2056527928C185592680 @default.
• W2056527928 hasConceptScore W2056527928C190283241 @default.
• W2056527928 hasConceptScore W2056527928C195794163 @default.
• W2056527928 hasConceptScore W2056527928C2779084600 @default.
• W2056527928 hasConceptScore W2056527928C2780427987 @default.
• W2056527928 hasConceptScore W2056527928C3018521938 @default.
• W2056527928 hasConceptScore W2056527928C3019054536 @default.
• W2056527928 hasConceptScore W2056527928C31573885 @default.
• W2056527928 hasConceptScore W2056527928C48297814 @default.
• W2056527928 hasConceptScore W2056527928C502942594 @default.

• next