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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056528668> ?p ?o ?g. }

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• W2056528668 abstract "TFII-I is a transcription factor and a target of phosphorylation by Bruton's tyrosine kinase. In humans, deletions spanning the TFII-I locus are associated with a cognitive defect, the Williams-Beuren cognitive profile. We report an unanticipated role of TFII-I outside the nucleus as a negative regulator of agonist-induced calcium entry (ACE) that suppresses surface accumulation of TRPC3 (transient receptor potential C3) channels. Inhibition of ACE by TFII-I requires phosphotyrosine residues that engage the SH2 (Src-homology 2) domains of phospholipase C–g (PLC-g) and an interrupted, pleckstrin homology (PH)–like domain that binds the split PH domain of PLC-g. Our observations suggest a model in which TFII-I suppresses ACE by competing with TRPC3 for binding to PLC-g." @default.
• W2056528668 created "2016-06-24" @default.
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• W2056528668 date "2006-10-06" @default.
• W2056528668 modified "2023-10-17" @default.
• W2056528668 title "Action of TFII-I Outside the Nucleus as an Inhibitor of Agonist-Induced Calcium Entry" @default.
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• W2056528668 doi "https://doi.org/10.1126/science.1127815" @default.
• W2056528668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17023658" @default.
• W2056528668 hasPublicationYear "2006" @default.
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