FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056528819> ?p ?o ?g. }

• W2056528819 endingPage "288" @default.
• W2056528819 startingPage "274" @default.
• W2056528819 abstract "Identification of the genes involved in prostate cancer (PCa) progression to a virulent and androgen-independent (AI) form is a major focus in the field. cDNA microarray was used to compare the gene expression profile of the indolent, androgen sensitive (AS) LNCaP PCa cell line to the aggressively metastatic, AI C4-2. Thirty-eight unique sequences from a 6388 cDNA array were found differentially expressed (> or =2-fold, 95% CI). The expression of 14 genes was lower in C4-2 than in LNCaP cells, while the reverse was true for 24 genes. Twelve genes were validated using Q-PCR, Western blotting and immunohistochemistry (IHC) of LNCaP and C4-2 xenograft. Q-PCR showed that 10 of 12 (83.3%) genes had similar patterns of expression to the array (LNCaP>C4-2: TMEFF2, ATP1B1, IL-8, BTG1, BChE, NKX3.1; LNCaP<C4-2: BNIP3, TM4SF1, AMACR, UCH-L1). By Western blot, 4/5 genes examined: TMEFF2, NKX3.1, AMACR, and UCH-L1, not IL-8, were consistent with RNA profiling. Protein expression levels were confirmed in human tumor xenografts using IHC. A large proportion of the markers found in this expression profile is consistent with those recently identified in human PCa tissues along with several novel genes that remain to be examined. These data further demonstrate the utility of the LNCaP human PCa progression model as a tool to investigate the phenotypic changes required for the progression to AI and metastasis." @default.
• W2056528819 created "2016-06-24" @default.
• W2056528819 creator A5012044666 @default.
• W2056528819 creator A5053733472 @default.
• W2056528819 creator A5064857468 @default.
• W2056528819 creator A5067800417 @default.
• W2056528819 creator A5068290128 @default.
• W2056528819 creator A5074350469 @default.
• W2056528819 creator A5079338108 @default.
• W2056528819 date "2006-12-01" @default.
• W2056528819 modified "2023-10-07" @default.
• W2056528819 title "Gene expression in the LNCaP human prostate cancer progression model: Progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo" @default.
• W2056528819 cites W1601814540 @default.
• W2056528819 cites W1775749144 @default.
• W2056528819 cites W1966180582 @default.
• W2056528819 cites W1967548067 @default.
• W2056528819 cites W1967573239 @default.
• W2056528819 cites W1971458073 @default.
• W2056528819 cites W1975120553 @default.
• W2056528819 cites W1978368163 @default.
• W2056528819 cites W1978566938 @default.
• W2056528819 cites W1982057232 @default.
• W2056528819 cites W1984880910 @default.
• W2056528819 cites W1996717896 @default.
• W2056528819 cites W2001471842 @default.
• W2056528819 cites W2009079495 @default.
• W2056528819 cites W2010397777 @default.
• W2056528819 cites W2012271909 @default.
• W2056528819 cites W2015556765 @default.
• W2056528819 cites W2016686667 @default.
• W2056528819 cites W2017757468 @default.
• W2056528819 cites W2023518719 @default.
• W2056528819 cites W2023862781 @default.
• W2056528819 cites W2028911827 @default.
• W2056528819 cites W2035397440 @default.
• W2056528819 cites W2035936829 @default.
• W2056528819 cites W2036468298 @default.
• W2056528819 cites W2036570902 @default.
• W2056528819 cites W2042587614 @default.
• W2056528819 cites W2043754674 @default.
• W2056528819 cites W2043829537 @default.
• W2056528819 cites W2051336039 @default.
• W2056528819 cites W2053548194 @default.
• W2056528819 cites W2053773278 @default.
• W2056528819 cites W2055184276 @default.
• W2056528819 cites W2059531568 @default.
• W2056528819 cites W2068261927 @default.
• W2056528819 cites W2069162430 @default.
• W2056528819 cites W2069826521 @default.
• W2056528819 cites W2073037382 @default.
• W2056528819 cites W2077829429 @default.
• W2056528819 cites W2080709087 @default.
• W2056528819 cites W2093312816 @default.
• W2056528819 cites W2095128237 @default.
• W2056528819 cites W2096315312 @default.
• W2056528819 cites W2099614758 @default.
• W2056528819 cites W2100314556 @default.
• W2056528819 cites W2101362932 @default.
• W2056528819 cites W2104762821 @default.
• W2056528819 cites W2105252948 @default.
• W2056528819 cites W2109847618 @default.
• W2056528819 cites W2112336517 @default.
• W2056528819 cites W2116575688 @default.
• W2056528819 cites W2128089900 @default.
• W2056528819 cites W2128667036 @default.
• W2056528819 cites W2129302018 @default.
• W2056528819 cites W2137330819 @default.
• W2056528819 cites W2151030236 @default.
• W2056528819 cites W2156215080 @default.
• W2056528819 cites W2167031568 @default.
• W2056528819 cites W2266036275 @default.
• W2056528819 cites W2330669764 @default.
• W2056528819 cites W2333927480 @default.
• W2056528819 cites W2886024925 @default.
• W2056528819 cites W2984785086 @default.
• W2056528819 cites W4242739891 @default.
• W2056528819 cites W4379614214 @default.
• W2056528819 doi "https://doi.org/10.1016/j.canlet.2005.12.027" @default.
• W2056528819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16500022" @default.
• W2056528819 hasPublicationYear "2006" @default.
• W2056528819 type Work @default.
• W2056528819 sameAs 2056528819 @default.
• W2056528819 citedByCount "55" @default.
• W2056528819 countsByYear W20565288192012 @default.
• W2056528819 countsByYear W20565288192013 @default.
• W2056528819 countsByYear W20565288192014 @default.
• W2056528819 countsByYear W20565288192015 @default.
• W2056528819 countsByYear W20565288192016 @default.
• W2056528819 countsByYear W20565288192017 @default.
• W2056528819 countsByYear W20565288192018 @default.
• W2056528819 countsByYear W20565288192019 @default.
• W2056528819 countsByYear W20565288192020 @default.
• W2056528819 countsByYear W20565288192021 @default.
• W2056528819 countsByYear W20565288192022 @default.
• W2056528819 crossrefType "journal-article" @default.
• W2056528819 hasAuthorship W2056528819A5012044666 @default.
• W2056528819 hasAuthorship W2056528819A5053733472 @default.
• W2056528819 hasAuthorship W2056528819A5064857468 @default.

• next