Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056529275> ?p ?o ?g. }
- W2056529275 endingPage "E9" @default.
- W2056529275 startingPage "E9" @default.
- W2056529275 abstract "Initial enthusiasm after promising Phase II trials for treating recurrent glioblastomas with the antiangiogenic drug bevacizumab—a neutralizing antibody targeting vascular endothelial growth factor—was tempered by recent Phase III trials showing no efficacy for treating newly diagnosed glioblastomas. As a result, there is uncertainty about the appropriate indications for the use of bevacizumab in glioblastoma treatment. There are also concerns about the effects of bevacizumab on wound healing that neurosurgeons must be aware of. In addition, biochemical evidence suggests a percentage of tumors treated with bevacizumab for an extended period of time will undergo transformation into a more biologically aggressive and invasive phenotype with a particularly poor prognosis. Despite these concerns, there remain numerous examples of radiological and clinical improvement after bevacizumab treatment, particularly in patients with recurrent glioblastoma with limited therapeutic options. In this paper, the authors review clinical results with bevacizumab for glioblastoma treatment to date, ongoing trials designed to address unanswered questions, current clinical indications based on existing data, neurosurgical implications of bevacizumab use in patients with glioblastoma, the current scientific understanding of the tumor response to short- and long-term bevacizumab treatment, and future studies that will need to be undertaken to enable this treatment to fulfill its therapeutic promise for glioblastoma." @default.
- W2056529275 created "2016-06-24" @default.
- W2056529275 creator A5035949278 @default.
- W2056529275 creator A5049126969 @default.
- W2056529275 date "2014-12-01" @default.
- W2056529275 modified "2023-10-09" @default.
- W2056529275 title "Bevacizumab for glioblastoma: current indications, surgical implications, and future directions" @default.
- W2056529275 cites W1482109403 @default.
- W2056529275 cites W1498349189 @default.
- W2056529275 cites W1579863504 @default.
- W2056529275 cites W1858161324 @default.
- W2056529275 cites W1862835589 @default.
- W2056529275 cites W1887747927 @default.
- W2056529275 cites W1898063915 @default.
- W2056529275 cites W1965491357 @default.
- W2056529275 cites W1968107383 @default.
- W2056529275 cites W1969328947 @default.
- W2056529275 cites W1974435973 @default.
- W2056529275 cites W1975373367 @default.
- W2056529275 cites W1977392502 @default.
- W2056529275 cites W1979985168 @default.
- W2056529275 cites W1987039497 @default.
- W2056529275 cites W1990289715 @default.
- W2056529275 cites W1994131389 @default.
- W2056529275 cites W2000292756 @default.
- W2056529275 cites W2001355942 @default.
- W2056529275 cites W2013897414 @default.
- W2056529275 cites W2014014583 @default.
- W2056529275 cites W2018016372 @default.
- W2056529275 cites W2020304503 @default.
- W2056529275 cites W2025359066 @default.
- W2056529275 cites W2025739022 @default.
- W2056529275 cites W2026827454 @default.
- W2056529275 cites W2044125840 @default.
- W2056529275 cites W2044214336 @default.
- W2056529275 cites W2046507292 @default.
- W2056529275 cites W2047138539 @default.
- W2056529275 cites W2048886867 @default.
- W2056529275 cites W2057423414 @default.
- W2056529275 cites W2063931866 @default.
- W2056529275 cites W2064214863 @default.
- W2056529275 cites W2067901299 @default.
- W2056529275 cites W2078326783 @default.
- W2056529275 cites W2078995022 @default.
- W2056529275 cites W2081392657 @default.
- W2056529275 cites W2093084676 @default.
- W2056529275 cites W2093783077 @default.
- W2056529275 cites W2096287682 @default.
- W2056529275 cites W2096415778 @default.
- W2056529275 cites W2096800614 @default.
- W2056529275 cites W2097373408 @default.
- W2056529275 cites W2099541268 @default.
- W2056529275 cites W2099808007 @default.
- W2056529275 cites W2109134893 @default.
- W2056529275 cites W2109648353 @default.
- W2056529275 cites W2111336617 @default.
- W2056529275 cites W2112030606 @default.
- W2056529275 cites W2116575184 @default.
- W2056529275 cites W2122831198 @default.
- W2056529275 cites W2123808042 @default.
- W2056529275 cites W2124350729 @default.
- W2056529275 cites W2124736921 @default.
- W2056529275 cites W2127745545 @default.
- W2056529275 cites W2129512401 @default.
- W2056529275 cites W2130852323 @default.
- W2056529275 cites W2132697290 @default.
- W2056529275 cites W2135245689 @default.
- W2056529275 cites W2135396269 @default.
- W2056529275 cites W2137832651 @default.
- W2056529275 cites W2142167347 @default.
- W2056529275 cites W2145224595 @default.
- W2056529275 cites W2147535764 @default.
- W2056529275 cites W2153384261 @default.
- W2056529275 cites W2153741461 @default.
- W2056529275 cites W2154200023 @default.
- W2056529275 cites W2156330848 @default.
- W2056529275 cites W2158681922 @default.
- W2056529275 cites W2159959305 @default.
- W2056529275 cites W2160959204 @default.
- W2056529275 cites W2161190434 @default.
- W2056529275 cites W2162643152 @default.
- W2056529275 cites W2163458899 @default.
- W2056529275 cites W2165772224 @default.
- W2056529275 cites W2165860547 @default.
- W2056529275 cites W2165871546 @default.
- W2056529275 cites W2167923186 @default.
- W2056529275 cites W2168414172 @default.
- W2056529275 cites W2170367762 @default.
- W2056529275 cites W2329791077 @default.
- W2056529275 cites W2340180801 @default.
- W2056529275 cites W2603438946 @default.
- W2056529275 cites W4240876290 @default.
- W2056529275 doi "https://doi.org/10.3171/2014.9.focus14516" @default.
- W2056529275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4839778" @default.
- W2056529275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25581938" @default.
- W2056529275 hasPublicationYear "2014" @default.
- W2056529275 type Work @default.
- W2056529275 sameAs 2056529275 @default.