FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056530157> ?p ?o ?g. }

• W2056530157 endingPage "355" @default.
• W2056530157 startingPage "348" @default.
• W2056530157 abstract "Introduction of the maleimide function via a spacer into histidine-containing peptides was found to produce ring closure by nucleophilic addition of the Nim-imino function of the histidine side-chain to the activated double bond of the maleimide. As an intramolecular cyciization reaction it proceeds at remarkably higher rates than the bimolecular alkylation of histidine derivatives with N-ethyl-maleimide. Correspondingly, in the case of the histidine-peptides examined only mixtures of the cyclic isomeric compounds were isolated and structurally characterized by 1H-NMR analysis. As expected, prevention of this reaction in histidine-containing maleoyl-peptides can be achieved by Nim-protection of the imidazole group. However, upon removal of this protection, the reaction takes place again, thus remarkably hampering the usefulness of the maleimide/thiol addition principle in conjugate chemistry for peptides. On the other hand this reaction could represent an interesting new approach for the design of cyclic peptidomimetic analogs." @default.
• W2056530157 created "2016-06-24" @default.
• W2056530157 creator A5003994757 @default.
• W2056530157 creator A5015855091 @default.
• W2056530157 creator A5029423573 @default.
• W2056530157 creator A5031623134 @default.
• W2056530157 creator A5055035215 @default.
• W2056530157 creator A5065468362 @default.
• W2056530157 date "2009-01-12" @default.
• W2056530157 modified "2023-09-26" @default.
• W2056530157 title "Alkylation of histidine with maleimido-compounds" @default.
• W2056530157 cites W2000165430 @default.
• W2056530157 cites W2031962656 @default.
• W2056530157 cites W2052202496 @default.
• W2056530157 cites W2062036962 @default.
• W2056530157 cites W2068731902 @default.
• W2056530157 cites W2074126072 @default.
• W2056530157 cites W2126394471 @default.
• W2056530157 cites W2326741568 @default.
• W2056530157 cites W2327305530 @default.
• W2056530157 cites W2397200323 @default.
• W2056530157 cites W2409049979 @default.
• W2056530157 cites W2409403156 @default.
• W2056530157 cites W2413880663 @default.
• W2056530157 cites W2468102957 @default.
• W2056530157 cites W2991851763 @default.
• W2056530157 cites W3201242461 @default.
• W2056530157 doi "https://doi.org/10.1111/j.1399-3011.1992.tb01594.x" @default.
• W2056530157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1428524" @default.
• W2056530157 hasPublicationYear "2009" @default.
• W2056530157 type Work @default.
• W2056530157 sameAs 2056530157 @default.
• W2056530157 citedByCount "16" @default.
• W2056530157 countsByYear W20565301572013 @default.
• W2056530157 countsByYear W20565301572015 @default.
• W2056530157 countsByYear W20565301572017 @default.
• W2056530157 countsByYear W20565301572019 @default.
• W2056530157 crossrefType "journal-article" @default.
• W2056530157 hasAuthorship W2056530157A5003994757 @default.
• W2056530157 hasAuthorship W2056530157A5015855091 @default.
• W2056530157 hasAuthorship W2056530157A5029423573 @default.
• W2056530157 hasAuthorship W2056530157A5031623134 @default.
• W2056530157 hasAuthorship W2056530157A5055035215 @default.
• W2056530157 hasAuthorship W2056530157A5065468362 @default.
• W2056530157 hasConcept C124790011 @default.
• W2056530157 hasConcept C134306372 @default.
• W2056530157 hasConcept C161790260 @default.
• W2056530157 hasConcept C164361826 @default.
• W2056530157 hasConcept C178790620 @default.
• W2056530157 hasConcept C178907741 @default.
• W2056530157 hasConcept C181199279 @default.
• W2056530157 hasConcept C185592680 @default.
• W2056530157 hasConcept C197336794 @default.
• W2056530157 hasConcept C21951064 @default.
• W2056530157 hasConcept C2778460671 @default.
• W2056530157 hasConcept C2779281246 @default.
• W2056530157 hasConcept C2780105360 @default.
• W2056530157 hasConcept C2780874372 @default.
• W2056530157 hasConcept C33923547 @default.
• W2056530157 hasConcept C55493867 @default.
• W2056530157 hasConcept C71240020 @default.
• W2056530157 hasConcept C75079739 @default.
• W2056530157 hasConceptScore W2056530157C124790011 @default.
• W2056530157 hasConceptScore W2056530157C134306372 @default.
• W2056530157 hasConceptScore W2056530157C161790260 @default.
• W2056530157 hasConceptScore W2056530157C164361826 @default.
• W2056530157 hasConceptScore W2056530157C178790620 @default.
• W2056530157 hasConceptScore W2056530157C178907741 @default.
• W2056530157 hasConceptScore W2056530157C181199279 @default.
• W2056530157 hasConceptScore W2056530157C185592680 @default.
• W2056530157 hasConceptScore W2056530157C197336794 @default.
• W2056530157 hasConceptScore W2056530157C21951064 @default.
• W2056530157 hasConceptScore W2056530157C2778460671 @default.
• W2056530157 hasConceptScore W2056530157C2779281246 @default.
• W2056530157 hasConceptScore W2056530157C2780105360 @default.
• W2056530157 hasConceptScore W2056530157C2780874372 @default.
• W2056530157 hasConceptScore W2056530157C33923547 @default.
• W2056530157 hasConceptScore W2056530157C55493867 @default.
• W2056530157 hasConceptScore W2056530157C71240020 @default.
• W2056530157 hasConceptScore W2056530157C75079739 @default.
• W2056530157 hasIssue "4" @default.
• W2056530157 hasLocation W20565301571 @default.
• W2056530157 hasLocation W20565301572 @default.
• W2056530157 hasOpenAccess W2056530157 @default.
• W2056530157 hasPrimaryLocation W20565301571 @default.
• W2056530157 hasRelatedWork W2030740953 @default.
• W2056530157 hasRelatedWork W2107742210 @default.
• W2056530157 hasRelatedWork W2131398154 @default.
• W2056530157 hasRelatedWork W2143767610 @default.
• W2056530157 hasRelatedWork W2772072791 @default.
• W2056530157 hasRelatedWork W2949200986 @default.
• W2056530157 hasRelatedWork W2949594889 @default.
• W2056530157 hasRelatedWork W2951106323 @default.
• W2056530157 hasRelatedWork W2951550788 @default.
• W2056530157 hasRelatedWork W4379768548 @default.
• W2056530157 hasVolume "39" @default.
• W2056530157 isParatext "false" @default.
• W2056530157 isRetracted "false" @default.

• next