FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056531341> ?p ?o ?g. }

• W2056531341 endingPage "97" @default.
• W2056531341 startingPage "87" @default.
• W2056531341 abstract "Abstract It is well known that functionalization of surfaces with cell adhesive peptides mimicking the integrin binding motif of extracellular matrix proteins is a feasible approach to improve osseointegration of implant materials. Also, modification of the surface properties of the material (e.g., roughness) strongly influences cell behavior. However, these two approaches are rarely studied together. This study addressed the hypothesis that the combination of peptide functionalization and surface roughness will have an enhancing effect on the adhesion process of osteoblasts. To test this hypothesis, a series of αvβ3‐selective cyclic RGD peptides were prepared and immobilized on trimmed ( S a = 0.74 μm, smooth) and sandblasted ( S a = 3.24 μm, rough) Ti6Al4V disks. Effects of these surface modifications were evaluated with respect to integrin αvβ3‐mediated adhesive capacity, cell morphology, and spreading of primary human osteoblasts. After 3 h of incubation, osteoblasts adhered more strongly on sandblasted than on trimmed noncoated Ti6Al4V surfaces. Their attachment efficiency was further enhanced in the presence of RGD peptides. However, peptide functionalization had a relatively stronger impact on osteoblast attachment on trimmed surfaces compared with sandblasted surfaces. Cell morphology after 3 h of culture was exclusively altered by surface topography. RGD coating was critical for osteoblast spreading on both trimmed and sandblasted materials after 1 h of incubation but it showed almost negligible effects after 3 h. The results of this study provide evidence that the alliance of RGD coating and surface topography on Ti6Al4V positively influences osteoblast adhesion and spreading, especially at very early adhesion times. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:87–97, 2013." @default.
• W2056531341 created "2016-06-24" @default.
• W2056531341 creator A5022140307 @default.
• W2056531341 creator A5037997825 @default.
• W2056531341 creator A5045631014 @default.
• W2056531341 creator A5059752140 @default.
• W2056531341 creator A5062197119 @default.
• W2056531341 creator A5072566909 @default.
• W2056531341 creator A5081381092 @default.
• W2056531341 date "2012-07-24" @default.
• W2056531341 modified "2023-10-14" @default.
• W2056531341 title "Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides" @default.
• W2056531341 cites W1573329015 @default.
• W2056531341 cites W1601103901 @default.
• W2056531341 cites W1970414768 @default.
• W2056531341 cites W1970438213 @default.
• W2056531341 cites W1971167899 @default.
• W2056531341 cites W1972911951 @default.
• W2056531341 cites W1974402000 @default.
• W2056531341 cites W1977455246 @default.
• W2056531341 cites W1977569147 @default.
• W2056531341 cites W1978244317 @default.
• W2056531341 cites W1980082793 @default.
• W2056531341 cites W1985966495 @default.
• W2056531341 cites W1986225001 @default.
• W2056531341 cites W1996013872 @default.
• W2056531341 cites W1997246078 @default.
• W2056531341 cites W1998761473 @default.
• W2056531341 cites W2001319878 @default.
• W2056531341 cites W2002803038 @default.
• W2056531341 cites W2005179396 @default.
• W2056531341 cites W2005425959 @default.
• W2056531341 cites W2008124574 @default.
• W2056531341 cites W2008189537 @default.
• W2056531341 cites W2013814323 @default.
• W2056531341 cites W2018655931 @default.
• W2056531341 cites W2024663962 @default.
• W2056531341 cites W2031445285 @default.
• W2056531341 cites W2032342275 @default.
• W2056531341 cites W2035110326 @default.
• W2056531341 cites W2042261220 @default.
• W2056531341 cites W2046723789 @default.
• W2056531341 cites W2052188334 @default.
• W2056531341 cites W2059864237 @default.
• W2056531341 cites W2062218490 @default.
• W2056531341 cites W2064484362 @default.
• W2056531341 cites W2065097700 @default.
• W2056531341 cites W2070963500 @default.
• W2056531341 cites W2072812561 @default.
• W2056531341 cites W2073457192 @default.
• W2056531341 cites W2074012988 @default.
• W2056531341 cites W2076991868 @default.
• W2056531341 cites W2082356756 @default.
• W2056531341 cites W2087535943 @default.
• W2056531341 cites W2100507537 @default.
• W2056531341 cites W2110470035 @default.
• W2056531341 cites W2114989145 @default.
• W2056531341 cites W2125675566 @default.
• W2056531341 cites W2127421666 @default.
• W2056531341 cites W2133607414 @default.
• W2056531341 cites W2134197804 @default.
• W2056531341 cites W2136471260 @default.
• W2056531341 cites W2153724762 @default.
• W2056531341 cites W2155308465 @default.
• W2056531341 doi "https://doi.org/10.1002/jbm.a.34303" @default.
• W2056531341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22826207" @default.
• W2056531341 hasPublicationYear "2012" @default.
• W2056531341 type Work @default.
• W2056531341 sameAs 2056531341 @default.
• W2056531341 citedByCount "53" @default.
• W2056531341 countsByYear W20565313412013 @default.
• W2056531341 countsByYear W20565313412014 @default.
• W2056531341 countsByYear W20565313412015 @default.
• W2056531341 countsByYear W20565313412016 @default.
• W2056531341 countsByYear W20565313412017 @default.
• W2056531341 countsByYear W20565313412018 @default.
• W2056531341 countsByYear W20565313412019 @default.
• W2056531341 countsByYear W20565313412020 @default.
• W2056531341 countsByYear W20565313412021 @default.
• W2056531341 countsByYear W20565313412022 @default.
• W2056531341 countsByYear W20565313412023 @default.
• W2056531341 crossrefType "journal-article" @default.
• W2056531341 hasAuthorship W2056531341A5022140307 @default.
• W2056531341 hasAuthorship W2056531341A5037997825 @default.
• W2056531341 hasAuthorship W2056531341A5045631014 @default.
• W2056531341 hasAuthorship W2056531341A5059752140 @default.
• W2056531341 hasAuthorship W2056531341A5062197119 @default.
• W2056531341 hasAuthorship W2056531341A5072566909 @default.
• W2056531341 hasAuthorship W2056531341A5081381092 @default.
• W2056531341 hasConcept C101414908 @default.
• W2056531341 hasConcept C107365816 @default.
• W2056531341 hasConcept C115537861 @default.
• W2056531341 hasConcept C12554922 @default.
• W2056531341 hasConcept C136229726 @default.
• W2056531341 hasConcept C141071460 @default.
• W2056531341 hasConcept C147789679 @default.
• W2056531341 hasConcept C1491633281 @default.
• W2056531341 hasConcept C159985019 @default.

• next