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- W2056531485 abstract "Heart failure is the most challenging disease throughout Europe accompanied by high morbidity and mortality. Recently, serum uric acid (SUA) level was shown to be an independent predictor of long-term mortality and morbidity in patients with cardiovascular diseases. The aims of this study were to investigate the relation between SUA level and clinical and echocardiographic parameters and the prognostic importance of SUA in patients with chronic systolic heart failure. In our study, 20 clinically stable (NYHA II) and 22 decompansated (NYHA III and IV) systolic CHF (EF<%40) patients were enrolled. The serum levels of pro-Brain Natriuretic Peptide (BNP), uric acid and high sensitive C-reactive protein (hs-CRP) were measured by ELISA method. The relation between these parameters and the prognostic significance of SUA were investigated with appropriate statistical methods. There was significant positive correlation between SUA and important clinical and echocardiographic prognostic parameters such as NYHA class (p=0.0001), ejection fraction (0.009) and tissue doppler peak systolic velosity of mitral annulus (p=0.03) respectively. However, there was no important relation between SUA, pro-BNP (p=0.216) and hs-CRP (p=0.72). Furthermore, the diagnostic value of SUA was found to be low (AUC 0.366 p=0.1) using by ROC curve analysis. In contrast to some other clinical studies, we could not show the SUA as a reliable prognostic marker in HF. Further clinical studies with bigger populations are needed to determine the prognostic role of SUA in this disease." @default.
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- W2056531485 date "2014-04-01" @default.
- W2056531485 modified "2023-10-02" @default.
- W2056531485 title "OP-099 The Prognostic Value of Serum Uric Acid Level in Systolic Heart Failure" @default.
- W2056531485 doi "https://doi.org/10.1016/j.amjcard.2014.01.074" @default.
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