Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056532781> ?p ?o ?g. }
- W2056532781 endingPage "107" @default.
- W2056532781 startingPage "107" @default.
- W2056532781 abstract "Low bone mineral density (BMD) is a primary risk factor for osteoporosis and is a highly heritable trait, but appears to be influenced by many genes. Genome-wide linkage studies have highlighted the chromosomal region 3p14-p22 as a quantitative trait locus for BMD (LOD 1.1 - 3.5). The FLNB gene, which is thought to have a role in cytoskeletal actin dynamics, is located within this chromosomal region and presents as a strong candidate for BMD regulation. We have previously identified significant associations between four SNPs in the FLNB gene and BMD in women. We have also previously identified associations between five SNPs located 5' of the transcription start site (TSS) and in intron 1 of the FLNB gene and expression of FLNB mRNA in osteoblasts in vitro. The latter five SNPs were genotyped in this study to test for association with BMD parameters in a family-based population of 769 Caucasian women. Using FBAT, significant associations were seen for femoral neck BMD Z-score with the SNPs rs11720285, rs11130605 and rs9809315 (P = 0.004 – 0.043). These three SNPs were also found to be significantly associated with total hip BMD Z-score (P = 0.014 – 0.026). We then combined the genotype data for these three SNPs with the four SNPs we previously identified as associated with BMD and performed a conditional analysis to determine whether they represent multiple independent associations with BMD. The results from this analysis suggested that these variants represent a single association signal. The SNPs identified in our studies as associated with BMD appear to be part of a single association signal between the FLNB gene and BMD in our data. FLNB is one of several genes located in 3p14-p22 that has been identified as significantly associated with BMD in Caucasian women." @default.
- W2056532781 created "2016-06-24" @default.
- W2056532781 creator A5002163035 @default.
- W2056532781 creator A5023142140 @default.
- W2056532781 creator A5026743197 @default.
- W2056532781 creator A5050190782 @default.
- W2056532781 creator A5056932776 @default.
- W2056532781 creator A5085801121 @default.
- W2056532781 date "2013-01-01" @default.
- W2056532781 modified "2023-10-07" @default.
- W2056532781 title "Conditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal" @default.
- W2056532781 cites W1500690807 @default.
- W2056532781 cites W1572749943 @default.
- W2056532781 cites W1972327726 @default.
- W2056532781 cites W1973295687 @default.
- W2056532781 cites W1990880008 @default.
- W2056532781 cites W1994262939 @default.
- W2056532781 cites W1995078934 @default.
- W2056532781 cites W1995200918 @default.
- W2056532781 cites W1997857542 @default.
- W2056532781 cites W2005445752 @default.
- W2056532781 cites W2005911829 @default.
- W2056532781 cites W2006070236 @default.
- W2056532781 cites W2015703307 @default.
- W2056532781 cites W2019731805 @default.
- W2056532781 cites W2028819440 @default.
- W2056532781 cites W2030409202 @default.
- W2056532781 cites W2039684521 @default.
- W2056532781 cites W2048305004 @default.
- W2056532781 cites W2048370641 @default.
- W2056532781 cites W2058401000 @default.
- W2056532781 cites W2065385842 @default.
- W2056532781 cites W2065766094 @default.
- W2056532781 cites W2072963204 @default.
- W2056532781 cites W2081140214 @default.
- W2056532781 cites W2083507730 @default.
- W2056532781 cites W2085939052 @default.
- W2056532781 cites W2089684334 @default.
- W2056532781 cites W2090204051 @default.
- W2056532781 cites W2095863048 @default.
- W2056532781 cites W2102616071 @default.
- W2056532781 cites W2106925861 @default.
- W2056532781 cites W2107237947 @default.
- W2056532781 cites W2109051498 @default.
- W2056532781 cites W2123411711 @default.
- W2056532781 cites W2139227862 @default.
- W2056532781 cites W2147351691 @default.
- W2056532781 cites W2147789998 @default.
- W2056532781 cites W2151339992 @default.
- W2056532781 cites W2153508883 @default.
- W2056532781 cites W2154176387 @default.
- W2056532781 cites W2160131637 @default.
- W2056532781 cites W2170693936 @default.
- W2056532781 doi "https://doi.org/10.1186/1471-2156-14-107" @default.
- W2056532781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3818969" @default.
- W2056532781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24176111" @default.
- W2056532781 hasPublicationYear "2013" @default.
- W2056532781 type Work @default.
- W2056532781 sameAs 2056532781 @default.
- W2056532781 citedByCount "7" @default.
- W2056532781 countsByYear W20565327812015 @default.
- W2056532781 countsByYear W20565327812016 @default.
- W2056532781 countsByYear W20565327812020 @default.
- W2056532781 crossrefType "journal-article" @default.
- W2056532781 hasAuthorship W2056532781A5002163035 @default.
- W2056532781 hasAuthorship W2056532781A5023142140 @default.
- W2056532781 hasAuthorship W2056532781A5026743197 @default.
- W2056532781 hasAuthorship W2056532781A5050190782 @default.
- W2056532781 hasAuthorship W2056532781A5056932776 @default.
- W2056532781 hasAuthorship W2056532781A5085801121 @default.
- W2056532781 hasBestOaLocation W20565327811 @default.
- W2056532781 hasConcept C104317684 @default.
- W2056532781 hasConcept C106208931 @default.
- W2056532781 hasConcept C135763542 @default.
- W2056532781 hasConcept C153209595 @default.
- W2056532781 hasConcept C168393362 @default.
- W2056532781 hasConcept C186413461 @default.
- W2056532781 hasConcept C2908647359 @default.
- W2056532781 hasConcept C54355233 @default.
- W2056532781 hasConcept C69991583 @default.
- W2056532781 hasConcept C71924100 @default.
- W2056532781 hasConcept C81941488 @default.
- W2056532781 hasConcept C84597430 @default.
- W2056532781 hasConcept C86803240 @default.
- W2056532781 hasConcept C99454951 @default.
- W2056532781 hasConceptScore W2056532781C104317684 @default.
- W2056532781 hasConceptScore W2056532781C106208931 @default.
- W2056532781 hasConceptScore W2056532781C135763542 @default.
- W2056532781 hasConceptScore W2056532781C153209595 @default.
- W2056532781 hasConceptScore W2056532781C168393362 @default.
- W2056532781 hasConceptScore W2056532781C186413461 @default.
- W2056532781 hasConceptScore W2056532781C2908647359 @default.
- W2056532781 hasConceptScore W2056532781C54355233 @default.
- W2056532781 hasConceptScore W2056532781C69991583 @default.
- W2056532781 hasConceptScore W2056532781C71924100 @default.
- W2056532781 hasConceptScore W2056532781C81941488 @default.
- W2056532781 hasConceptScore W2056532781C84597430 @default.
- W2056532781 hasConceptScore W2056532781C86803240 @default.