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- W2056533839 abstract "In patients with myeloproliferative disorders (MPD) an altered sensitivity of platelets to antiaggregatory prostaglandins and to the endoperoxide analogue U 46619 has been found. In this study we examined U 46619-induced platelet aggregation and binding of the endoperoxide/thromboxane A2 (TXA2) receptor antagonist SQ 29548 in 11 patients with MPD and 11 healthy controls. Although platelet responsiveness to U 46619 was significantly enhanced (p less than 0.05) in MPD, binding affinity and binding capacity of the corresponding endoperoxide/TXA2 receptor were not altered (Bmax 0.67 +/- 0.20 vs. 0.58 +/- 0.14 pmol/10(9) platelets, Kd 0.41 +/- 0.11 vs. 0.55 +/- 0.09 nM). These data exclude the possibility that changes in the presentation of endoperoxide/TXA2 receptors are responsible for the enhanced platelet sensitivity to endoperoxides found in MPD." @default.
- W2056533839 created "2016-06-24" @default.
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- W2056533839 date "1991-08-01" @default.
- W2056533839 modified "2023-09-26" @default.
- W2056533839 title "Platelet endoperoxide/thromboxane A2 () receptors in patients with myeloproliferative disorders" @default.
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- W2056533839 doi "https://doi.org/10.1016/0952-3278(91)90042-4" @default.
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