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• W2056534030 endingPage "469" @default.
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• W2056534030 abstract "A live attenuated Salmonella typhimurium vaccine candidate, LVR01, was constructed by introducing a null deletion into the aroC gene of the parental canine S. typhimurium isolate, P228067. LVR01 was used to orally deliver to the canine immune system a fatty acid binding protein (FABP) from Echinococcus granulosus (EgDf1), as a fusion protein with fragment C (TetC) of tetanus toxin. Immunization studies demonstrated that live LVR01 is well tolerated by orally vaccinated dogs. There was no detectable shedding of the vaccine strain in the faeces 2 days after immunization. Humoral antibody responses were observed against Salmonella, TetC and EgDf1. Cellular responses were consistently detected against Salmonella and TetC. A cellular response against EgDf1 was also seen in a proportion of the LVR01 vaccinated dogs. We propose S. typhimurium LVR01 as a carrier for recombinant antigens and a vector for the construction of multivalent oral vaccines for dogs." @default.
• W2056534030 created "2016-06-24" @default.
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• W2056534030 date "2000-10-15" @default.
• W2056534030 modified "2023-10-01" @default.
• W2056534030 title "Salmonella typhimurium as a basis for a live oral Echinococcus granulosus vaccine" @default.
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• W2056534030 doi "https://doi.org/10.1016/s0264-410x(00)00197-3" @default.
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