FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056536636> ?p ?o ?g. }

• W2056536636 endingPage "604" @default.
• W2056536636 startingPage "599" @default.
• W2056536636 abstract "Prevention of graft rejection in renal transplant recipients depends on chronic treatment with immunosuppressive agents. However, impaired immune functions and immunosurveillance may cause infection, cancer and many other problems, which subsequently compromise quality of life and survival of patients. In the present study, we assessed potential premature immune-senescence in long-term survivors of kidney transplant patients receiving immunosuppressive agents. Peripheral blood lymphocytes derived from patients had significantly shorter telomeres than those from age- and sex-matched healthy individuals. Consistent with this, lower expression of telomerase reverse transcriptase (hTERT) and telomerase activity was observed in patients’ lymphocytes. The level of p16ink4A expression was elevated in patients’ cells. Moreover, the CD8+/CD28− fraction of late-stage differentiated T cells was significantly increased in the patients. In vitro studies further showed that cyclosporine A, a widely used immunosuppressive drug in transplant patients, attenuated induction of hTERT and telomerase activation in T cells treated with the mitogenic agent concanavalin A. Taken together, immunosuppressant-mediated premature senescence of T lymphocytes occurs in renal transplant recipients." @default.
• W2056536636 created "2016-06-24" @default.
• W2056536636 creator A5029646781 @default.
• W2056536636 creator A5046644939 @default.
• W2056536636 creator A5057660178 @default.
• W2056536636 creator A5063481044 @default.
• W2056536636 creator A5064487640 @default.
• W2056536636 creator A5073070877 @default.
• W2056536636 creator A5074641183 @default.
• W2056536636 creator A5074882599 @default.
• W2056536636 date "2011-04-01" @default.
• W2056536636 modified "2023-10-11" @default.
• W2056536636 title "Premature senescence of T cells in long-term survivors of renal transplantation" @default.
• W2056536636 cites W1586815424 @default.
• W2056536636 cites W1972292377 @default.
• W2056536636 cites W1988379270 @default.
• W2056536636 cites W1994893447 @default.
• W2056536636 cites W1995613141 @default.
• W2056536636 cites W1999230822 @default.
• W2056536636 cites W2022387553 @default.
• W2056536636 cites W2042377388 @default.
• W2056536636 cites W2046151348 @default.
• W2056536636 cites W2048088192 @default.
• W2056536636 cites W2052122863 @default.
• W2056536636 cites W2070439612 @default.
• W2056536636 cites W2080808232 @default.
• W2056536636 cites W2086007558 @default.
• W2056536636 cites W2100702324 @default.
• W2056536636 cites W2106305381 @default.
• W2056536636 cites W2120562400 @default.
• W2056536636 cites W2142540220 @default.
• W2056536636 cites W2158157056 @default.
• W2056536636 cites W2160621707 @default.
• W2056536636 cites W2168520556 @default.
• W2056536636 doi "https://doi.org/10.1016/j.bbrc.2011.03.079" @default.
• W2056536636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21426898" @default.
• W2056536636 hasPublicationYear "2011" @default.
• W2056536636 type Work @default.
• W2056536636 sameAs 2056536636 @default.
• W2056536636 citedByCount "15" @default.
• W2056536636 countsByYear W20565366362012 @default.
• W2056536636 countsByYear W20565366362013 @default.
• W2056536636 countsByYear W20565366362014 @default.
• W2056536636 countsByYear W20565366362015 @default.
• W2056536636 countsByYear W20565366362016 @default.
• W2056536636 countsByYear W20565366362019 @default.
• W2056536636 countsByYear W20565366362020 @default.
• W2056536636 countsByYear W20565366362021 @default.
• W2056536636 countsByYear W20565366362022 @default.
• W2056536636 crossrefType "journal-article" @default.
• W2056536636 hasAuthorship W2056536636A5029646781 @default.
• W2056536636 hasAuthorship W2056536636A5046644939 @default.
• W2056536636 hasAuthorship W2056536636A5057660178 @default.
• W2056536636 hasAuthorship W2056536636A5063481044 @default.
• W2056536636 hasAuthorship W2056536636A5064487640 @default.
• W2056536636 hasAuthorship W2056536636A5073070877 @default.
• W2056536636 hasAuthorship W2056536636A5074641183 @default.
• W2056536636 hasAuthorship W2056536636A5074882599 @default.
• W2056536636 hasConcept C104317684 @default.
• W2056536636 hasConcept C125593758 @default.
• W2056536636 hasConcept C126322002 @default.
• W2056536636 hasConcept C148125776 @default.
• W2056536636 hasConcept C167672396 @default.
• W2056536636 hasConcept C177336024 @default.
• W2056536636 hasConcept C19869320 @default.
• W2056536636 hasConcept C202751555 @default.
• W2056536636 hasConcept C203014093 @default.
• W2056536636 hasConcept C2776885095 @default.
• W2056536636 hasConcept C2778330430 @default.
• W2056536636 hasConcept C2779056147 @default.
• W2056536636 hasConcept C2780252810 @default.
• W2056536636 hasConcept C2911091166 @default.
• W2056536636 hasConcept C522857546 @default.
• W2056536636 hasConcept C54355233 @default.
• W2056536636 hasConcept C552990157 @default.
• W2056536636 hasConcept C55493867 @default.
• W2056536636 hasConcept C71924100 @default.
• W2056536636 hasConcept C86803240 @default.
• W2056536636 hasConcept C8891405 @default.
• W2056536636 hasConcept C94581717 @default.
• W2056536636 hasConceptScore W2056536636C104317684 @default.
• W2056536636 hasConceptScore W2056536636C125593758 @default.
• W2056536636 hasConceptScore W2056536636C126322002 @default.
• W2056536636 hasConceptScore W2056536636C148125776 @default.
• W2056536636 hasConceptScore W2056536636C167672396 @default.
• W2056536636 hasConceptScore W2056536636C177336024 @default.
• W2056536636 hasConceptScore W2056536636C19869320 @default.
• W2056536636 hasConceptScore W2056536636C202751555 @default.
• W2056536636 hasConceptScore W2056536636C203014093 @default.
• W2056536636 hasConceptScore W2056536636C2776885095 @default.
• W2056536636 hasConceptScore W2056536636C2778330430 @default.
• W2056536636 hasConceptScore W2056536636C2779056147 @default.
• W2056536636 hasConceptScore W2056536636C2780252810 @default.
• W2056536636 hasConceptScore W2056536636C2911091166 @default.
• W2056536636 hasConceptScore W2056536636C522857546 @default.
• W2056536636 hasConceptScore W2056536636C54355233 @default.
• W2056536636 hasConceptScore W2056536636C552990157 @default.
• W2056536636 hasConceptScore W2056536636C55493867 @default.

• next