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- W2056537307 abstract "We previously investigated the pharmacokinetics of R- and S-carvedilol in 54 healthy Japanese subjects, and reported that the oral clearance (CL/F) and apparent volume of distribution (V/F) of both enantiomers in subjects with the CYP2D6*10 allele were significantly lower than those in subjects without the CYP2D6*10 allele. In the present study, we examined the genotype of UGT2B7 in these 54 subjects, and investigated the effect of UGT2B7*3 on the pharmacokinetics of R- and S-carvedilol. Forty-three subjects did not have the UGT2B7*3 allele, and 11 subjects had one UGT2B7*3 allele. CL/F and V/F values of R- and S-carvedilol in the subjects with one UGT2B7*3 allele were similar to those without the UGT2B7*3 allele, indicating that the UGT2B7*3 allele did not significantly affect the systemic clearance (CL) and bioavailability (F) of the two enantiomers." @default.
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- W2056537307 date "2007-01-01" @default.
- W2056537307 modified "2023-09-27" @default.
- W2056537307 title "UGT2B7*3 did not Affect the Pharmacokinetics of R- and S-Carvedilol in Healthy Japanese" @default.
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- W2056537307 doi "https://doi.org/10.2133/dmpk.22.382" @default.
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