FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056537433> ?p ?o ?g. }

• W2056537433 endingPage "93" @default.
• W2056537433 startingPage "85" @default.
• W2056537433 abstract "Targeting both mitochondrial bioenergetics and glycolysis pathway is an effective way to inhibit proliferation of tumour cells, including those that are resistant to conventional chemotherapeutics. In this study, using the Seahorse 96-well Extracellular Flux Analyzer, we mapped the two intrinsic cellular bioenergetic parameters, oxygen consumption rate and proton production rate in six different pancreatic cancer cell lines and determined their differential sensitivity to mitochondrial and glycolytic inhibitors. There exists a very close relationship among intracellular bioenergetic parameters, depletion of ATP and anti-proliferative effects (inhibition of colony-forming ability) in pancreatic cancer cells derived from different genetic backgrounds treated with the glycolytic inhibitor, 2-deoxyglucose (2-DG). The most glycolytic pancreatic cancer cell line was exquisitely sensitive to 2-DG, whereas the least glycolytic pancreatic cancer cell was resistant to 2-DG. However, when combined with metformin, inhibitor of mitochondrial respiration and activator of AMP-activated protein kinase, 2-DG synergistically enhanced ATP depletion and inhibited cell proliferation even in poorly glycolytic, 2-DG-resistant pancreatic cancer cell line. Furthermore, treatment with conventional chemotherapeutic drugs (e.g., gemcitabine and doxorubicin) or COX-2 inhibitor, celecoxib, sensitised the cells to 2-DG treatment. Detailed profiling of cellular bioenergetics can provide new insight into the design of therapeutic strategies for inhibiting pancreatic cancer cell metabolism and proliferation." @default.
• W2056537433 created "2016-06-24" @default.
• W2056537433 creator A5011165903 @default.
• W2056537433 creator A5033077836 @default.
• W2056537433 creator A5041591287 @default.
• W2056537433 creator A5053435940 @default.
• W2056537433 creator A5078771244 @default.
• W2056537433 creator A5081128645 @default.
• W2056537433 date "2014-05-27" @default.
• W2056537433 modified "2023-10-07" @default.
• W2056537433 title "Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation" @default.
• W2056537433 cites W1502641261 @default.
• W2056537433 cites W1968457108 @default.
• W2056537433 cites W1969704731 @default.
• W2056537433 cites W1971324216 @default.
• W2056537433 cites W1976603231 @default.
• W2056537433 cites W1978528142 @default.
• W2056537433 cites W1979569154 @default.
• W2056537433 cites W1980083426 @default.
• W2056537433 cites W1987874136 @default.
• W2056537433 cites W1988428451 @default.
• W2056537433 cites W1988430091 @default.
• W2056537433 cites W1993038196 @default.
• W2056537433 cites W1996365670 @default.
• W2056537433 cites W2008062764 @default.
• W2056537433 cites W2014988241 @default.
• W2056537433 cites W2024377584 @default.
• W2056537433 cites W2031628684 @default.
• W2056537433 cites W2042008937 @default.
• W2056537433 cites W2049857745 @default.
• W2056537433 cites W2052543023 @default.
• W2056537433 cites W2056648518 @default.
• W2056537433 cites W2057545963 @default.
• W2056537433 cites W2059623168 @default.
• W2056537433 cites W2076112957 @default.
• W2056537433 cites W2090406819 @default.
• W2056537433 cites W2092152920 @default.
• W2056537433 cites W2097259163 @default.
• W2056537433 cites W2099616702 @default.
• W2056537433 cites W2100148709 @default.
• W2056537433 cites W2105665764 @default.
• W2056537433 cites W2109636091 @default.
• W2056537433 cites W2110401386 @default.
• W2056537433 cites W2116516144 @default.
• W2056537433 cites W2125292576 @default.
• W2056537433 cites W2130503287 @default.
• W2056537433 cites W2135349706 @default.
• W2056537433 cites W2144280397 @default.
• W2056537433 cites W2146780639 @default.
• W2056537433 cites W2154024784 @default.
• W2056537433 cites W2158076290 @default.
• W2056537433 cites W2158240289 @default.
• W2056537433 cites W2161859769 @default.
• W2056537433 cites W2162790428 @default.
• W2056537433 cites W2167436791 @default.
• W2056537433 cites W2168277151 @default.
• W2056537433 cites W2168919362 @default.
• W2056537433 cites W2168992025 @default.
• W2056537433 cites W2331672431 @default.
• W2056537433 cites W4244578979 @default.
• W2056537433 doi "https://doi.org/10.1038/bjc.2014.272" @default.
• W2056537433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4090735" @default.
• W2056537433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24867695" @default.
• W2056537433 hasPublicationYear "2014" @default.
• W2056537433 type Work @default.
• W2056537433 sameAs 2056537433 @default.
• W2056537433 citedByCount "69" @default.
• W2056537433 countsByYear W20565374332014 @default.
• W2056537433 countsByYear W20565374332015 @default.
• W2056537433 countsByYear W20565374332016 @default.
• W2056537433 countsByYear W20565374332017 @default.
• W2056537433 countsByYear W20565374332018 @default.
• W2056537433 countsByYear W20565374332019 @default.
• W2056537433 countsByYear W20565374332020 @default.
• W2056537433 countsByYear W20565374332021 @default.
• W2056537433 countsByYear W20565374332022 @default.
• W2056537433 countsByYear W20565374332023 @default.
• W2056537433 crossrefType "journal-article" @default.
• W2056537433 hasAuthorship W2056537433A5011165903 @default.
• W2056537433 hasAuthorship W2056537433A5033077836 @default.
• W2056537433 hasAuthorship W2056537433A5041591287 @default.
• W2056537433 hasAuthorship W2056537433A5053435940 @default.
• W2056537433 hasAuthorship W2056537433A5078771244 @default.
• W2056537433 hasAuthorship W2056537433A5081128645 @default.
• W2056537433 hasBestOaLocation W20565374331 @default.
• W2056537433 hasConcept C100206155 @default.
• W2056537433 hasConcept C121608353 @default.
• W2056537433 hasConcept C20251656 @default.
• W2056537433 hasConcept C2780210213 @default.
• W2056537433 hasConcept C28859421 @default.
• W2056537433 hasConcept C502942594 @default.
• W2056537433 hasConcept C54355233 @default.
• W2056537433 hasConcept C55493867 @default.
• W2056537433 hasConcept C62112901 @default.
• W2056537433 hasConcept C62231903 @default.
• W2056537433 hasConcept C79879829 @default.
• W2056537433 hasConcept C81885089 @default.
• W2056537433 hasConcept C86803240 @default.

• next