Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056538167> ?p ?o ?g. }
- W2056538167 endingPage "196" @default.
- W2056538167 startingPage "190" @default.
- W2056538167 abstract "Thirteen patients with recurrent medulloblastoma were treated with cyclophosphamide in association with Sargramostim. Cyclophosphamide was given at doses ranging between 1.0–2.5 g/m2 daily for two doses. Sargramostim was given at a fixed dose of 250 μg/m2 subcutaneously twice a day beginning 24 hours after the second cyclophosphamide dose and continuing through the leukocyte nadir until the ANC was more than 1,000 cells/μl for two consecutive days. A total of 33 courses were given with toxicity consisting of grade 4 neutropenia in all courses and grade 3–4 thrombocytopenia in 10 of 13 patients. There were no deaths related to infection or bleeding. Four patients were taken off study because of prolonged myelosuppression. Three of these patients were at the 2.5 g/m2 level, and of these three, two developed lung toxicity (grades 2 and 4, respectively). One patient developed an allergic reaction following the first injection of Sargramostim and was also taken off study. Of 10 evaluable patients, there were 9 PR and 1 SD. We conclude that cyclophosphamide at a dose of 2.0 g/m2/day × 2 days q 4 weeks in association with Sargramostim demonstrates marked activity with acceptable toxicity in patients with recurrent medulloblastoma. © 1995 Wiley-Liss, Inc." @default.
- W2056538167 created "2016-06-24" @default.
- W2056538167 creator A5000296172 @default.
- W2056538167 creator A5001810450 @default.
- W2056538167 creator A5002034160 @default.
- W2056538167 creator A5002449505 @default.
- W2056538167 creator A5004814459 @default.
- W2056538167 creator A5008949370 @default.
- W2056538167 creator A5017799212 @default.
- W2056538167 creator A5020554337 @default.
- W2056538167 creator A5035053292 @default.
- W2056538167 creator A5043673217 @default.
- W2056538167 creator A5050683295 @default.
- W2056538167 creator A5057225248 @default.
- W2056538167 creator A5057371623 @default.
- W2056538167 creator A5060384074 @default.
- W2056538167 creator A5061456315 @default.
- W2056538167 creator A5062561302 @default.
- W2056538167 creator A5065566520 @default.
- W2056538167 creator A5073501312 @default.
- W2056538167 creator A5074209384 @default.
- W2056538167 date "1995-09-01" @default.
- W2056538167 modified "2023-10-15" @default.
- W2056538167 title "Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma" @default.
- W2056538167 cites W1980560578 @default.
- W2056538167 cites W1988405755 @default.
- W2056538167 cites W2005894868 @default.
- W2056538167 cites W2015131798 @default.
- W2056538167 cites W2033660880 @default.
- W2056538167 cites W2037394188 @default.
- W2056538167 cites W2037946157 @default.
- W2056538167 cites W2051980905 @default.
- W2056538167 cites W2058486772 @default.
- W2056538167 cites W2059935943 @default.
- W2056538167 cites W2065910438 @default.
- W2056538167 cites W2083616014 @default.
- W2056538167 cites W2097779050 @default.
- W2056538167 cites W2104996683 @default.
- W2056538167 cites W2121896285 @default.
- W2056538167 cites W2171492359 @default.
- W2056538167 cites W2227545313 @default.
- W2056538167 cites W2230642230 @default.
- W2056538167 cites W2259682466 @default.
- W2056538167 cites W2285560870 @default.
- W2056538167 cites W2313477330 @default.
- W2056538167 cites W2337660074 @default.
- W2056538167 cites W4244591305 @default.
- W2056538167 doi "https://doi.org/10.1002/mpo.2950250306" @default.
- W2056538167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7623728" @default.
- W2056538167 hasPublicationYear "1995" @default.
- W2056538167 type Work @default.
- W2056538167 sameAs 2056538167 @default.
- W2056538167 citedByCount "28" @default.
- W2056538167 countsByYear W20565381672012 @default.
- W2056538167 crossrefType "journal-article" @default.
- W2056538167 hasAuthorship W2056538167A5000296172 @default.
- W2056538167 hasAuthorship W2056538167A5001810450 @default.
- W2056538167 hasAuthorship W2056538167A5002034160 @default.
- W2056538167 hasAuthorship W2056538167A5002449505 @default.
- W2056538167 hasAuthorship W2056538167A5004814459 @default.
- W2056538167 hasAuthorship W2056538167A5008949370 @default.
- W2056538167 hasAuthorship W2056538167A5017799212 @default.
- W2056538167 hasAuthorship W2056538167A5020554337 @default.
- W2056538167 hasAuthorship W2056538167A5035053292 @default.
- W2056538167 hasAuthorship W2056538167A5043673217 @default.
- W2056538167 hasAuthorship W2056538167A5050683295 @default.
- W2056538167 hasAuthorship W2056538167A5057225248 @default.
- W2056538167 hasAuthorship W2056538167A5057371623 @default.
- W2056538167 hasAuthorship W2056538167A5060384074 @default.
- W2056538167 hasAuthorship W2056538167A5061456315 @default.
- W2056538167 hasAuthorship W2056538167A5062561302 @default.
- W2056538167 hasAuthorship W2056538167A5065566520 @default.
- W2056538167 hasAuthorship W2056538167A5073501312 @default.
- W2056538167 hasAuthorship W2056538167A5074209384 @default.
- W2056538167 hasConcept C126322002 @default.
- W2056538167 hasConcept C141071460 @default.
- W2056538167 hasConcept C142724271 @default.
- W2056538167 hasConcept C2776694085 @default.
- W2056538167 hasConcept C2776755627 @default.
- W2056538167 hasConcept C2777063308 @default.
- W2056538167 hasConcept C2780789225 @default.
- W2056538167 hasConcept C29730261 @default.
- W2056538167 hasConcept C71924100 @default.
- W2056538167 hasConcept C90924648 @default.
- W2056538167 hasConceptScore W2056538167C126322002 @default.
- W2056538167 hasConceptScore W2056538167C141071460 @default.
- W2056538167 hasConceptScore W2056538167C142724271 @default.
- W2056538167 hasConceptScore W2056538167C2776694085 @default.
- W2056538167 hasConceptScore W2056538167C2776755627 @default.
- W2056538167 hasConceptScore W2056538167C2777063308 @default.
- W2056538167 hasConceptScore W2056538167C2780789225 @default.
- W2056538167 hasConceptScore W2056538167C29730261 @default.
- W2056538167 hasConceptScore W2056538167C71924100 @default.
- W2056538167 hasConceptScore W2056538167C90924648 @default.
- W2056538167 hasIssue "3" @default.
- W2056538167 hasLocation W20565381671 @default.
- W2056538167 hasLocation W20565381672 @default.
- W2056538167 hasOpenAccess W2056538167 @default.