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- W2056538346 abstract "β-lactam induction of chromosomal β-lactamase in gram-negative bacteria requires the transcriptional regulator AmpR and the transport of murein breakdown products (muropeptides) into the cytoplasm. In vitro transcription shows that purified AmpR acts as an activator for ampCβ-lactamase synthesis. The murein precursor, UDP-MurNAc-pentapeptide, decreases AmpR-mediated transcriptional activation in vitro, but has no effect on an AmpR(G102E) mutant that mediates constitutive activation of ampC in vivo. Addition of the muropeptide, anhMurNAc-tripeptide, which accumulates in β-lactamase-overproducing mutants, counteracts the negative effect of UDP-MurNAc-pentapeptide, restoring the innate ability of AmpR to induce ampC expression in vitro. Cytosolic intermediates of murein biosynthesis and degradation thus act antagonistically to control β-lactamase expression, thereby operating as a cell–wall sensing device." @default.
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- W2056538346 date "1997-03-01" @default.
- W2056538346 modified "2023-10-18" @default.
- W2056538346 title "Cytosolic Intermediates for Cell Wall Biosynthesis and Degradation Control Inducible β-Lactam Resistance in Gram-Negative Bacteria" @default.
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- W2056538346 doi "https://doi.org/10.1016/s0092-8674(00)81928-5" @default.
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