FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056538994> ?p ?o ?g. }

• W2056538994 endingPage "254" @default.
• W2056538994 startingPage "248" @default.
• W2056538994 abstract "Lung cancer is one of the most common types of cancer and is the leading cause of cancer-related mortality worldwide. Estrogens are known to be involved in the development and progression of non-small-cell lung cancer (NSCLC). These effects are initially mediated through binding of estrogen to estrogen receptors (ERs), in particular ERβ2. Our preliminary studies demonstrated that ERβ2 and interleukin-12 receptorβ2 (IL-12Rβ2) expression are correlated in NSCLC. The present study investigated the expression of these proteins in NSCLC cells and how changes in their expression affected cell proliferation and invasion. In addition, it aimed to explore whether p38 mitogen-activated protein kinase (p38MAPK) is involved in the regulation of IL-12Rβ2 expression by ERβ2. An immunocytochemical array was used to observe the distribution of ERβ2 and IL-12Rβ2. Co-immuoprecipitation was employed to observe the interaction between p38MAPK and IL-12Rβ2, by varying the expression of ERβ2 and p38MAPK. Western-blot analysis and reverse transcription-polymerase chain reaction assays were used to investigate the mechanism underlying ERβ2 regulation of IL-12Rβ2 expression. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, scratch wound healing and Transwell assays were used to investigate the impact of ERβ2 on proliferative, invasive and migratory abilities of NSCLC cells. ERβ2 was predominantly found in the cytoplasm and nucleus, whilst IL-12Rβ2 was largely confined to the cytoplasm, although a degree of expression was observed in the nucleus. Compared with normal bronchial epithelial cells, IL-12Rβ2 and ERβ2 were overexpressed in the NSCLC cell groups. Coimmuoprecipitation demonstrated an interaction between p38MAPK and IL-12Rβ2. ERβ2 appeared to upregulate IL-12Rβ2 expression and inhibition of p38MAPK attenuated this effect. ERβ2 and IL-12Rβ2 expression inhibited the proliferation, metastasis and invasion of NSCLC cell lines, but knockout of IL-12Rβ2, even in the presence of ERβ2, led to an increase in NSCLC cell proliferation and invasiveness. In conclusion, to the best of our knowledge this study is the first to demonstrate that IL-12Rβ2 may be important in the mechanisms underlying ERβ2 inhibition of NSCLC development, and that this interaction may be mediated via p38MAPK." @default.
• W2056538994 created "2016-06-24" @default.
• W2056538994 creator A5042456385 @default.
• W2056538994 creator A5061468604 @default.
• W2056538994 creator A5076417896 @default.
• W2056538994 creator A5082662127 @default.
• W2056538994 creator A5082779603 @default.
• W2056538994 date "2012-02-17" @default.
• W2056538994 modified "2023-10-01" @default.
• W2056538994 title "Estrogen receptorβ2 regulates interlukin-12 receptorβ2 expression via p38 mitogen-activated protein kinase signaling and inhibits non-small-cell lung cancer proliferation and invasion" @default.
• W2056538994 cites W1862373525 @default.
• W2056538994 cites W1892231355 @default.
• W2056538994 cites W1977375752 @default.
• W2056538994 cites W1978363604 @default.
• W2056538994 cites W1983428140 @default.
• W2056538994 cites W1986833942 @default.
• W2056538994 cites W2011409010 @default.
• W2056538994 cites W2022632065 @default.
• W2056538994 cites W2028691872 @default.
• W2056538994 cites W2030929676 @default.
• W2056538994 cites W2033584253 @default.
• W2056538994 cites W2036016285 @default.
• W2056538994 cites W2043642585 @default.
• W2056538994 cites W2045719740 @default.
• W2056538994 cites W2049038243 @default.
• W2056538994 cites W2065093310 @default.
• W2056538994 cites W2065543971 @default.
• W2056538994 cites W2068059987 @default.
• W2056538994 cites W2080683349 @default.
• W2056538994 cites W2088260481 @default.
• W2056538994 cites W2092335007 @default.
• W2056538994 cites W2118128074 @default.
• W2056538994 cites W2131967117 @default.
• W2056538994 cites W2141861181 @default.
• W2056538994 cites W2143283599 @default.
• W2056538994 cites W2153631705 @default.
• W2056538994 cites W2168691181 @default.
• W2056538994 cites W4242638449 @default.
• W2056538994 cites W4322574879 @default.
• W2056538994 doi "https://doi.org/10.3892/mmr.2015.3366" @default.
• W2056538994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25695486" @default.
• W2056538994 hasPublicationYear "2012" @default.
• W2056538994 type Work @default.
• W2056538994 sameAs 2056538994 @default.
• W2056538994 citedByCount "3" @default.
• W2056538994 countsByYear W20565389942016 @default.
• W2056538994 countsByYear W20565389942019 @default.
• W2056538994 crossrefType "journal-article" @default.
• W2056538994 hasAuthorship W2056538994A5042456385 @default.
• W2056538994 hasAuthorship W2056538994A5061468604 @default.
• W2056538994 hasAuthorship W2056538994A5076417896 @default.
• W2056538994 hasAuthorship W2056538994A5082662127 @default.
• W2056538994 hasAuthorship W2056538994A5082779603 @default.
• W2056538994 hasBestOaLocation W20565389941 @default.
• W2056538994 hasConcept C121608353 @default.
• W2056538994 hasConcept C172313692 @default.
• W2056538994 hasConcept C502942594 @default.
• W2056538994 hasConcept C530470458 @default.
• W2056538994 hasConcept C54355233 @default.
• W2056538994 hasConcept C62478195 @default.
• W2056538994 hasConcept C84606932 @default.
• W2056538994 hasConcept C86803240 @default.
• W2056538994 hasConcept C95444343 @default.
• W2056538994 hasConceptScore W2056538994C121608353 @default.
• W2056538994 hasConceptScore W2056538994C172313692 @default.
• W2056538994 hasConceptScore W2056538994C502942594 @default.
• W2056538994 hasConceptScore W2056538994C530470458 @default.
• W2056538994 hasConceptScore W2056538994C54355233 @default.
• W2056538994 hasConceptScore W2056538994C62478195 @default.
• W2056538994 hasConceptScore W2056538994C84606932 @default.
• W2056538994 hasConceptScore W2056538994C86803240 @default.
• W2056538994 hasConceptScore W2056538994C95444343 @default.
• W2056538994 hasIssue "1" @default.
• W2056538994 hasLocation W20565389941 @default.
• W2056538994 hasLocation W20565389942 @default.
• W2056538994 hasOpenAccess W2056538994 @default.
• W2056538994 hasPrimaryLocation W20565389941 @default.
• W2056538994 hasRelatedWork W2010710786 @default.
• W2056538994 hasRelatedWork W2033031091 @default.
• W2056538994 hasRelatedWork W2045417389 @default.
• W2056538994 hasRelatedWork W2392244645 @default.
• W2056538994 hasRelatedWork W244829472 @default.
• W2056538994 hasRelatedWork W2881463645 @default.
• W2056538994 hasRelatedWork W2911124779 @default.
• W2056538994 hasRelatedWork W2947444821 @default.
• W2056538994 hasRelatedWork W3136690232 @default.
• W2056538994 hasRelatedWork W4238214718 @default.
• W2056538994 hasVolume "12" @default.
• W2056538994 isParatext "false" @default.
• W2056538994 isRetracted "false" @default.
• W2056538994 magId "2056538994" @default.
• W2056538994 workType "article" @default.