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• W2056539006 startingPage "137" @default.
• W2056539006 abstract "Recent studies show that a mononuclear phagocyte lineage, including microglia, plays a possible role in the pathogenesis of Alzheimer's disease through nitric oxide (NO)-mediated neurotoxicity. Epidemiological studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) have a protective effect against Alzheimer's disease. Based on these observations, it has been hypothesized that an anti-Alzheimer's disease effect of NSAIDs could result from the inhibition of NO synthesis. We report here that indomethacin or ibuprofen dose-dependently reduce beta-amyloid protein and interferon-gamma-induced NO production, accompanied by an inhibition of inducible nitric oxide synthase mRNA expression in J774 cells, a murine macrophage cell line. Aspirin, however, does not produce such an effect, suggesting that the cyclooxygenases pathway is not involved in the inhibitory effects of NSAIDs on beta-amyloid protein and interferon-gamma-induced NO production in J774 cells." @default.
• W2056539006 created "2016-06-24" @default.
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• W2056539006 date "2000-11-01" @default.
• W2056539006 modified "2023-10-10" @default.
• W2056539006 title "Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in β-amyloid protein-stimulated J774 cells" @default.
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• W2056539006 doi "https://doi.org/10.1016/s0014-2999(00)00721-4" @default.
• W2056539006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11080519" @default.
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